Influence of the Concentration of Leukemic Inoculum on the Effectiveness of Treatment

Observations on Blood Group Distribution in Peptic Ulcer and Gastric Cancer

“…Clarke, Cowan, Edwards, Howel-Evans, McConnell, Woodrow, and Sheppard (1955) and Buckwalter, Wohlwend, Colter, Tidrick, and Knowler (1956) distinguished medically and surgically treated cases, and Brown et al (1956) examined separately those patients whose ulcers had bled or perforated. No evidence was obtained to suggest that there was likely to be a substantial difference between the different groups.…”

Blood Groups of Gastric Ulcer and Carcinoma

“…K0ster et al (1955) and Mosbech and Hauze (1956) found an association between group A and achlorhydria, but Brown et al (1956) and Buckwalter et al (1956a found none. These results do not help to explain the association between gastric cancer and group A, and between gastric ulcer and group 0. Woolf (1955) demonstrated a hereditable component in cancer of the stomach, finding that actual deaths due to gastric cancer in relatives were greater than expected.…”

“…With the mathematical technique of Woolf (1955) it is possible to combine the various authors' series. It will be recalled that a statistically significant excess of group A in gastric cancer was not claimed by all investigators, yet when all the series were combined (Aird et al, 1953;Walther et al, 1956;Wallace, 1954;K0ster et al, 1955;Speiser, 1956;Buckwalter et al, 1956a;Billington, 1956b;Hollander, quoted by Aird et al, 1953) it was shown by Fraser Roberts (1957) that there was an overall association with group A, and that the centres were not significantly heterogeneous. Using the same method, he demonstrated an excess of 0 in patients with gastric ulcers, from series quoted by Aird et al (1954), Clarke et al (1955), K0ster et al (1955), Brown et al (1956), Heist0 (1956), Speiser (1956), Buckwalter et al (1956b.…”

“…Similarly, the findings of Aird et al for gastric ulcer have been followed by a diversity of results. K0ster et al (1955( ), Heist0 (1956, and Buckwalter et al (1956b) agreed, but Clarke (1955), Clarke, Cowan, Wyn Edwards, Howel-Evans, McConnell, Woodrow, and Sheppard (1955), Billington (1956a), and Brown, Melrose, and Wallace (1956) found no significant difference between controls and patients with gastric ulcer.…”

Radiation Genetics and Human Populations

“…A notable exception is the sickle-cell polym orphic system among African negroes, where there is evidence th a t heterozygotes are unusually resistant to infection w ith m alaria (Allison [1954]). O ther exceptions relate to gastric carcinom a and peptic ulceration, on the one hand, and the ABO blood group system on the other; in four bodies of data the wholly heterozygous AB class showed a lower incidence of th e disease th an did the wholly homozygous 0 or the partly homozygous A and B classes (Aird, Bentall and Fraser Roberts [1953], Holländer [1953], Buckwalter, Wohlwend, Colter and Tidrick [1956]). (ü) Optimal central phenotype.…”