Observations on Blood Group Distribution in Peptic Ulcer and Gastric Cancer

ABO Blood Groups and Risk of Cancer: a Systematic Review and Meta-analysis

“…Some studies included multiple cancer sites, and we analyzed these data separately by site, and the total number of studies by site is 123. Among these studies, we identified 36 studies reported results on gastric cancer (AIRD et al, 1953;AIRD et al, 1954;BILLINGTON, 1956;BUCKWALTER et al, 1958;EISENBERG et al, 1958;MACMAHON et al, 1958;BIRNBAUM et al, 1959;BEASLEY et al, 1960;DOLL et al, 1960;BECKMAN et al, 1961;COTTER et al, 1961;NEWMAN et al, 1961;Hartmann et al, 1964;LISKER et al, 1964;Hoskins et al, 1965;Macafee et al, 1967;Glober et al, 1971;van Wayjen et al, 1973;Newell et al, 1974;Akumabor et al, 1986;Kurtenkov et al, 1995;Klaamas et al, 1999;Su et al, 2001;Kamlesh et al, 2005;El et al, 2007;Edgren et al, 2010;Akhtar et al, 2010;Qiu et al, 2011;Gong et al, 2012;Song et al, 2013), 13 studies on pancreatic cancer (AIRD et al, 1960;Newell et al, 1974;Annese et al, 1990;Wolpin et al, 2009;Greer et al, 2010;Wolpin et al, 2010;Ben et al, 2011;Engin et al, 2012;…”

Gastric ulcers, blood groups, and acid secretion

“…Recurrent ulcers carry a particularly high proportion (Doll and Swynnerton, 1960), and the tendency for recurrences to occur mainly among gross oversecretors of acid was commented on many years ago (Wright, 1935;Orr and Johnson, 1947). Baron (1963) has demonstrated a gradient of acid secretion, ulcers in the body of the stomach being associated with the lowest and ulcers near the pylorus with the highest, levels.…”

Factors in the Pathogenesis of Peptic Ulcer: The Present Basis of Treatment

“…The increased risk associated with Group O is not apparent among siblings, an intriguing fact which is so far unexplained.l4 The association of Group O with stomal ulcer is greater than the association with duodenal ulcer, patients of blood group O developing this complication about I.8 times more often than patients of other groups.28 So far there is no evidence that the severity of duodenal ulcer, as judged by the age of onset or the necessity for surgical treatment, is related to blood group. 28 The A, B and H blood group substances may be secreted into the saliva and other secretions (H-substance is present in the tissues of people of all blood groups and is apparently independent of the ABO system). People who do not secrete these substances, 'non-secretors', have an increased liability to duodenal ulcer and this liability is independent of the blood group.…”