Influence of the bursa of Fabricius on the pathogenesis of Marek's disease

Schat, Karel A.; Calnek, B. W.; Fabricant, J.

doi:10.1128/iai.31.1.199-207.1981

Cited by 48 publications

(15 citation statements)

References 26 publications

(17 reference statements)

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“…Shek et al (1983) showed that bursa-derived lymphocytes (B cells) were the predominant cell type involved in the early cytolytic infection with MDV in vivo and that subsequent latent infections were found mostly in Ia-bearing non-B lymphocytes, presumably T cells. This fitted the pattern suggested by an earlier study by Schat et al (1981a) in which embryonally bursectomized chickens, free of B cells, failed to exhibit early cytolytic MDV infection but did develop latent infection and tumors. Calnek et al (1982) studied in vitro infection of spleen cells and learned that B cells were the major target of cytolytic infection in that system as well.…”

supporting

confidence: 89%

Further characterization of marek's disease virus‐infected lymphocytes. I. In vivo infection

Calnek

Schat

Ross

et al. 1984

Intl Journal of Cancer

106

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Previous reports from this laboratory identified bursaderived lymphocytes (B cells) and non-B cells as the predominant cell types respectively involved in the early cytolytic and subsequent latent infection of chickens with Marek's disease virus (MDV). It was not known whether these differences were qualitative or quantitative or if the method for detection of latent infection (viral antigen production after 48 h of in v i h o cultivation) was sensitive enough. To further define the cells involved in the various phases of MDV infection, we used monoclonal antibodies which specifically react with B cells, or T cells, or la-antigen-bearing cells. Dual fluorescence tests to detect surface markers and viral internal antigen (VIA) were conducted

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supporting

confidence: 89%

Further characterization of marek's disease virus‐infected lymphocytes. I. In vivo infection

Calnek

Schat

Ross

et al. 1984

Intl Journal of Cancer

106

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“…Indeed, this process was recapitulated in vitro by the co-culture of MDV-infected B cells with CD4 + T cells [99]. However, other studies showed that the depletion of B cells by chemicals [100], X-ray irradiation, and/or surgical removal of the bursa of Fabricius [98,101] did not consistently lead to the reduction in viral replication in chickens [92], rendering the role of B cells in MDV pathogenesis inconclusive. Recently, using Ig heavy chain J gene segment knockout (JH-KO) chickens that are deficient in mature and peripheral B cells, Bertzbach et al showed that in the absence of B cells, viral load in the blood of infected animals was not altered.…”

Section: B Cellsmentioning

confidence: 99%

Revisiting cellular immune response to oncogenic Marek’s disease virus: the rising of avian T-cell immunity

Yang

Dong

Hao

et al. 2020

Cell. Mol. Life Sci.

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Marek's disease virus (MDV) is a highly oncogenic alphaherpesvirus that causes deadly T-cell lymphomas and serves as a natural virus-induced tumor model in chickens. Although Marek's disease (MD) is well controlled by current vaccines, the evolution of MDV field viruses towards increasing virulence is concerning as a better vaccine to combat very virulent plus MDV is still lacking. Our understanding of molecular and cellular immunity to MDV and its immunopathogenesis has significantly improved, but those findings about cellular immunity to MDV are largely out-of-date, hampering the development of more effective vaccines against MD. T-cell-mediated cellular immunity was thought to be of paramount importance against MDV. However, MDV also infects macrophages, B cells and T cells, leading to immunosuppression and T-cell lymphoma. Additionally, there is limited information about how uninfected immune cells respond to MDV infection or vaccination, specifically, the mechanisms by which T cells are activated and recognize MDV antigens and how the function and properties of activated T cells correlate with immune protection against MDV or MD tumor. The current review revisits the roles of each immune cell subset and its effector mechanisms in the host immune response to MDV infection or vaccination from the point of view of comparative immunology. We particularly emphasize areas of research requiring further investigation and provide useful information for rational design and development of novel MDV vaccines.

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“…the ellipsoidassociated cells in the spleen (20,22,23,24). Then the virus is transferred to B lymphocytes, which become lethally infected and infect T lymphocytes, which can be transformed by MDV (25,26). Supposedly, MDV infects T lymphocytes between day 7 and 14 after infection, which coincides with the period of depletion of thymocytes by CAV.…”

Section: Score Of Infiltrates Atmentioning

confidence: 99%

Chicken anaemia virus influences the pathogenesis of Marek's disease in experimental infections, depending on the dose of Marek's disease virus

Jeurissen¹,

Boer²

1993

Veterinary Quarterly

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Eight groups of 1-day-old chickens were inoculated with 0, 250, 5000, or 100,000 white blood cells of chickens infected with Marek's disease virus strain K (MDV-WBC). Four of these groups were additionally infected with 10(5) TCID50 chicken anaemia virus (CAV). At day 14 after inoculation, chickens infected with CAV had reduced haematocrit levels, reduced body weights, and depletion of the thymic cortex and bone marrow. Semi-quantitative immunohistochemical examination of nerves and visceral organs was performed at day 28 by immunoperoxidase staining in which a monoclonal antibody specific for leucocytes was used. CAV significantly enhanced the number of lymphoproliferative lesions induced by 5000 MDV-WBC. In contrast, CAV significantly reduced the number of lymphoproliferative lesions induced by 100,000 MDV-WBC. Comparable results were found at day 61 after macroscopic examination of nerves and visceral organs. These findings show that the pathogenesis of MD in experimental infections appears to be enhanced or inhibited by CAV, depending on the dose of MDV.

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Influence of the bursa of Fabricius on the pathogenesis of Marek's disease

Cited by 48 publications

References 26 publications

Further characterization of marek's disease virus‐infected lymphocytes. I. In vivo infection

Further characterization of marek's disease virus‐infected lymphocytes. I. In vivo infection

Revisiting cellular immune response to oncogenic Marek’s disease virus: the rising of avian T-cell immunity

Chicken anaemia virus influences the pathogenesis of Marek's disease in experimental infections, depending on the dose of Marek's disease virus

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