Influence of the ancillary ligands on the luminescence of platinum(II) complexes with a triazole-based tridentate C^N^N luminophore

Monoanionic C^N^N Luminophores and Monodentate C-Donor Co-Ligands for Phosphorescent Pt(II) Complexes: A Case Study Involving Their Photophysics and Cytotoxicity

“…Interestingly, at rt, the k r for complex (4) is at least twice as large as for the other complexes in fluid solutions at rt, which points to a larger MLCT character. As expected for a stronger ligand-field splitting, k nr is somewhat lower for the C^N^C-coordinated compounds (6, 9) . ,, However, it is paradoxically higher for the stronger π-acceptors ( i.e. , CN – and the methylated ligand).…”

“…With these scopes in mind, we designed new derivatives of our previously established C^N^N luminophores and combined them with different ancillary ligands to optimize the photophysical properties while controlling their aggregation, based on the bulk of the substituents and their protrusion out of the coordination plane. , It is worth mentioning at this point that Pt···Pt interactions can be diminished or even suppressed by the addition of bulky ligands in the coordination sphere, as observed previously in numerous related compounds. ,,, In this context, allenylidene-derived co-ligands can yield bright coordination compounds while being accessible from the corresponding acetylido complexes. , In addition, new species bearing a bulky out-of-plane-twisted N -heterocyclic carbene (NHC) co-ligand were explored to prevent aggregation while improving the photophysical properties. Furthermore, we investigated the molecular structures of representative complexes as determined by single crystal X-ray diffractometric analysis.…”

Targeting Guanine Quadruplexes with Luminescent Platinum(II) Complexes Bearing a Pendant Nucleobase

“…Silica gel column chromatography was carried out by using Silica‐60, having a particle size of 40–63 μm, purchased from VWR. Benzyl azide, [41] the ligand precursor H L , [29a] L PtCl, [29a] L PtCCPh, [29a] and [ L Ptpy]PF 6 [29b] were synthesized as reported earlier. The synthesis of other precursor compounds (A‐ n , T‐ n ) is reported in the Supplementary Information.…”

Topical progress in medicinal applications of self‐assembled organoplatinum complexes using diverse Pt(II)‐ and N‐based tectons

“…[ 91 ] These are important additions to the literature since there are fewer reports of Pt(II)‐based inorganic complexes with 1,2,3‐triazole motifs incorporated in the structure. [ 99 ]…”

“…[91] These are important additions to the literature since there are fewer reports of Pt(II)-based inorganic complexes with 1,2,3-triazole motifs incorporated in the structure. [99] The biological activity of these compounds was compared by estimating their cytotoxicity against three cell lines (MG-63, MD-MB-231, and HDF) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) cell viability assay. The experimental results suggest that these compounds are nearly three times more potent in their respective antiproliferative activity relative to cisplatin.…”