Results from this study suggest that AGEs formed through glycation and glycoxidation may play an important role in the development of retinal neovascularization. The immunoreactivity of CML-AGEs in neovascular membrane and its increased levels in serum suggest that inspite of the normoglycemic status, glycoxidation and lipid peroxidation due to oxidative stress may trigger retinal neovascularization in Eales' disease, while MG-AGEs in diabetic membrane and serum suggest the role of glycation. Thus the mechanism of neovascularization in different pathological conditions could be different.
A new terpyridine-diphos hybrid ligand [4'-{p-(PhP)NCH}-2,2':6'2''-terpy] (1) and its Ru, Pd, Au and Zn complexes are described. Preliminary studies on absorption and emission properties are also reported.
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