Influence of Test Model Selection on Nanotoxicity Evaluation

Adeyemi, Oluyomi Stephen; Otohinoyi, David Adeiza; Sulaiman, Faoziyat Adenike

doi:10.1201/b21545-7

Cited by 3 publications

(6 citation statements)

References 1 publication

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“…This finding confirms earlier report which showed that NPs can increase cellular susceptibility to cell death without necessarily causing cytotoxicity (Leite et al, 2015). The PtNPs exhibited poor cellular apoptosis possibly due to the fact that PtNPs have anti-oxidative stress properties similar to those of cellular antioxidant enzymes (Adeyemi et al, 2018a). Nevertheless, studies have demonstrated in vitro apoptotic tendency of PtNPs in cancer cells, human fibroblast as well as in bacteria cells (Bendale et al, 2017;Kutwin et al, 2017; bacterial cells and HFF cells (Nejdl et al, 2017).…”

Section: Discussionsupporting

confidence: 89%

“…AgNPs have been implicated for cytotoxic efficacy applicable in cancer therapy (Azizi et al, 2017). AuNPs are inert and biocompatible and these have been applied as theranostics as well as for phototherapy (Moses et al, 2016;Rieznichenko et al, 2012) while PtNPs are noted for antioxidant properties that mimic catalase and superoxide dismutase (Sulaiman et al, 2015;Adeyemi et al, 2018a). As a further testament of the increasing popularity of NPs for biomedical applications, the potential of NPs against Toxoplasma gondii infection was recently reported (Adeyemi et al, 2017a;Adeyemi et al, 2017b).…”

Section: Introductionmentioning

confidence: 99%

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Cellular apoptosis of HFF cells by inorganic nanoparticles not susceptible to modulation by Toxoplasma gondii infection in vitro

Adeyemi

Otohinoyi

Awakan

et al. 2019

Toxicology in Vitro

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The interaction of nanoparticles with living cells is becoming one of the urgent areas of collaborative research in materials science and biology. Previously, we showed that nanoparticles have promising anti-Toxoplasma gondii properties. Meanwhile, Toxoplasma gondii has been shown to avert apoptosis in host cells whereas nanoparticles have been implicated for apoptotic tendency. Therefore, in the present study, we assessed the in vitro apoptotic properties of inorganic nanoparticles in the absence or presence of Toxoplasma infection and/or small molecules used as metabolic modulators. Results showed that inorganic nanoparticles dose-dependently caused cellular apoptosis. However, in the presence of infection by Toxoplasma gondii, nanoparticles-induced cellular apoptosis was not mitigated. Likewise, use of several small molecules (anti-metabolites) as metabolic modulators either mildly or nearly failed to abate cellular apoptosis by nanoparticles. Taken together, our findings do not only confirm the apoptotic potential of inorganic nanoparticles but show evidence that cellular apoptosis by inorganic nanoparticles of gold and silver might not be susceptible to modulation by Toxoplasma gondii infection. The findings are new and contribute to deepen our understanding of the cellular interaction of nanoparticles.

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Section: Discussionsupporting

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Cellular apoptosis of HFF cells by inorganic nanoparticles not susceptible to modulation by Toxoplasma gondii infection in vitro

Adeyemi

Otohinoyi

Awakan

et al. 2019

Toxicology in Vitro

Self Cite

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“…Designing a nano‐sized drug carrier to enhance the preferential accumulation of cancer drug in cancer tissues or cells is a promising approach to cancer treatment . A variety of materials, such as polymers , metal nanoparticles , quantum dots and carbon material , have been reported to serve as drug carriers. To enhance cancer treatment, there is a tendency in the literature recently in the development of nuclear‐targeted drug carriers because some anticancer drugs rely on targeting at nuclear DNA .…”

Section: Introductionmentioning

confidence: 99%

Graphene quantum dot based charge‐reversal nanomaterial for nucleus‐targeted drug delivery and efficiency controllable photodynamic therapy

Regmi

et al. 2019

Journal of Biophotonics

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Graphene quantum dots (GQDs), the new zero‐dimensional carbon nanomaterial, have been demonstrated as a promising material for biomedical applications due to its good biocompatibility and low toxicity. However, the integration of multiple therapeutic approaches into a nanosized platform based on the GQD has not been explored yet to our best knowledge. In this report, we regulate the generation of reactive oxygen species (ROS) when using the GQD as a photosensitizer by varying the doping amount of nitrogen atoms to achieve efficiency controllable photodynamic therapy. On the other hand, charge‐reversal (3‐Aminopropyl) triethoxysilane (APTES) was used to conjugate on the surface of GQD for nucleus targeting drug delivery for the first time. The treatment outcome of produced ROS and nucleus‐targeting drug delivery was investigated by fluorescence imaging. The results demonstrated that the N‐GQD‐DOX‐APTES in dual roles as a drug carrier and photosensitizer could achieve nucleus‐targeting delivery and strong ROS production simultaneously. This approach provides a promising strategy for the development of multifunctional therapy in one nano platform for biomedical applications.

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“…CVs are effective at demonstrating formal talents, but they are less helpful at revealing values and conduct. The distinction between competences (the capacity to perform anything) and skills is typically not made on resumes [28].…”

Section: Methods Of Recruitmentmentioning

confidence: 99%

“…Opinions are central to almost all human activities and are key influencers of our behaviors. Our beliefs and perceptions of reality, and the choices we make, are, to a considerable degree, conditioned upon how others see and evaluate the world [28]. For this reason, when we need to decide we often seek out the opinions of others.…”

Section: Suitability Of Artificial Intelligence and Sentiment Analysi...mentioning

confidence: 99%

A Sentiment Analysis Based Model for Recruitment by Higher Institutions

Uloko,

Enihe,

Obrorindo

2023

JCC

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The traditional roles of a university are teaching and research with the aim of developing society and contributing positively to the national economic development by producing skilled and well-tutored graduates. However, recruitments by these higher institutions are too reliant on the eligibility provided by Resumes of candidates, while neglecting their suitability drawn from their research activity and publications online. This study identifies insights in recruitment trends in higher institutions of learning and uses Artificial Intelligence to produce a more rounded and balanced decision-making process that caters for both eligibility and suitability. The methodology employs the machine learning process using the Multinomial Naïve Bayes for training the model as well as the Vader sentiment analyzer for accuracy and testing. The datasets used contained Resume instances as well as author publication information. The results show a score of 83.9% for the model as well as a sentiment analysis score of 1, indicating an overall positive score. The results show that sentiment analysis can help educational institutions in improving their recruitment models and attracting more suitable candidates for such roles.

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Influence of Test Model Selection on Nanotoxicity Evaluation

Cited by 3 publications

References 1 publication

Cellular apoptosis of HFF cells by inorganic nanoparticles not susceptible to modulation by Toxoplasma gondii infection in vitro

Cellular apoptosis of HFF cells by inorganic nanoparticles not susceptible to modulation by Toxoplasma gondii infection in vitro

Graphene quantum dot based charge‐reversal nanomaterial for nucleus‐targeted drug delivery and efficiency controllable photodynamic therapy

A Sentiment Analysis Based Model for Recruitment by Higher Institutions

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