Influence of Terminalia bellerica Roxb. Fruit Extracts on Biochemical 
 Parameters in Streptozotocin Diabetic Rats

Latha, R; Daisy, P.

doi:10.3923/ijp.2010.89.96

Cited by 28 publications

(12 citation statements)

References 20 publications

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“…As shown in the Table 1 there is significant increase in the serum level of urea, uric acid, and creatinine in the diabetic rats when compared with respective normal control rats, while after the treatment of diabetic rats with ethanolic extract of the C. cyminum seeds the levels of urea, uric acid, and creatinine were significantly (P \ 0.05) decreased. These results are in agreement with other previous studies on the fruit extract of Terminalia bellerica (Latha and Daisy, 2010), and roots of Hemidesmus indicus (Mahalingam and Kannabiran, 2010). Numerous studies have been reported on animal models that mimic human diabetes.…”

Section: Discussionsupporting

confidence: 83%

Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models

et al. 2010

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The ethanolic extract of seeds of Cuminum cyminum (C.c) was found to improve glucose tolerance to the tune of around 18.3% (P \ 0.01) in normal rats and shows around 17.7% (P \ 0.01) and 17.1% fall on blood glucose levels at 0-300 and 0-1440 min, respectively, on streptozotocin-induced diabetic rats at an oral dose of 250 mg/Kg body weight. The extract has also been found to improve around 26.7% (P \ 0.01) glucose intolerance on 14th day post treatment in high fructose fed streptozotocininduced diabetic rats. The extract was also found to have antidyslipidemic activity as evident by 21.04% (P \ 0.01) decline in serum triglycerides, 22.7% (P \ 0.01) decline in total serum cholesterol, and 16.9% of decline in serum LDL-C, respectively, along with 12.2% (P \ 0.05) increase in serum HDL-C on high fat diet fed male Syrian golden hamster. The extract was also found inhibitory to eye lens aldose reductase (EC 1.1.1.21) with IC 50 value of 7.07 lg/ml as compared to the standard AR inhibiting compound Quercetin which showed IC 50 2.35 lg/ml. The extract was also found inhibitory to a-glucosidase with IC 50 value of 100 lg/ml as compared to known drug Acarbose which showed IC 50 of around 25 lg/ml.

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Section: Discussionsupporting

confidence: 83%

Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models

et al. 2010

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“…Although the fruit of T. bellirica is used to treat various ailments, including diabetes mellitus, [12][13][14] the mechanism is unknown. T. bellirica extract has the effects as follows: hypoglycemic, [15][16][17] hypolipidemic, [18][19][20] antihypertensive, 21) antioxidant, 22,23) and antiobesity. 24) Therefore, it is reasonable to speculate that T. bellirica will prevent the symptoms of metabolic syndrome.…”

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confidence: 99%

Gallic Acid, the Active Ingredient of <i>Terminalia bellirica</i>, Enhances Adipocyte Differentiation and Adiponectin Secretion

Makihara

Koike

Ohta

et al. 2016

Biological & Pharmaceutical Bulletin

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Visceral obesity induces the onset of metabolic disorders such as insulin resistance and diabetes mellitus. Adipose tissue is considered as a potential pharmacological target for treating metabolic disorders. The fruit of Terminalia bellirica is extensively used in Ayurvedic medicine to treat patients with diseases such as diabetes mellitus. We previously investigated the effects of a hot water extract of T. bellirica fruit (TB) on obesity and insulin resistance in spontaneously obese type 2 diabetic mice. To determine the active ingredients of TB and their molecular mechanisms, we focused on adipocyte differentiation using mouse 3T3-L1 cells, which are widely used to study adipocyte physiology. We show here that TB enhanced the differentiation of 3T3-L1 cells to mature adipocytes and that one of the active main components was identified as gallic acid. Gallic acid (10-30 µM) enhanced the expression and secretion of adiponectin via adipocyte differentiation and also that of fatty acid binding protein-4, which is the target of peroxisome proliferator-activated receptor gamma (PPARγ), although it does not alter the expression of the upstream genes PPARγ and CCAAT enhancer binding protein alpha. In the PPARγ ligand assay, the binding of gallic acid to PPARγ was undetectable. These findings indicate that gallic acid mediates the therapeutic effects of TB on metabolic disorders by regulating adipocyte differentiation. Therefore, TB shows promise as a candidate for preventing and treating patients with metabolic syndrome.Key words Terminalia bellirica; gallic acid; adipocyte differentiation; adiponectin; metabolic-disorder therapy Visceral obesity induces the onset of metabolic syndrome symptoms such as insulin resistance, diabetes mellitus, abnormal lipid metabolism, and hypertension. Adipose tissue is an endocrine organ that secretes various adipocytokines associated with the accumulation of visceral fat and insulin sensitivity.1) The adipocytes of obese individuals become hypertrophic with a diminished ability to secrete adiponectin, which enhances insulin sensitivity. Adipose tissue plays a major role in mediating the actions of insulin, and is therefore considered a potential pharmacological target for treating the symptoms of metabolic syndrome.Thiazolidinediones are antidiabetic agents that stimulate adipocyte differentiation and enhance insulin sensitivity, 2,3) however they cause adverse effects such as unexpected weight gain, edema, and hepatotoxicity. 4) Therefore, it is important to investigate alternative sources of more efficacious and safer therapeutics. Recently, a number of natural products were discovered that affect adipocyte differentiation [5][6][7][8][9][10][11] and are therefore attracting increased attention.The fruit of Terminalia bellirica (GAERTN.) ROXB. is extensively used in Ayurvedic medicine in India and neighboring countries. Although the fruit of T. bellirica is used to treat various ailments, including diabetes mellitus, [12][13][14] the mechanism is unknown. T. bellirica extract has ...

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“…In addition, the plant extracts significantly decreased the serum levels of total cholesterol, triglycerides, LDL-C, urea, uric acid, and creatinine in diabetic rats. [34] Chanaka Yoga is a nutraceutical preparation prescribed for the treatment of urinary disorders including DM mentioned in ancient Ayurvedic treatise, i.e., Vaidya Chintamani. Based on this reference, the present work has been carried out to reveal its efficacy in the management of Type II DM.…”

Section: Clinical Assessment Based On Objective Parametersmentioning

confidence: 99%

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Reddy

2016

IJGP

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Influence of Terminalia bellerica Roxb. Fruit Extracts on Biochemical Parameters in Streptozotocin Diabetic Rats

Cited by 28 publications

References 20 publications

Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models

Antidiabetic and antidyslipidemic activities of Cuminum cyminum L. in validated animal models

Gallic Acid, the Active Ingredient of <i>Terminalia bellirica</i>, Enhances Adipocyte Differentiation and Adiponectin Secretion

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