Influence of temporal relationships between serotonergic and dopaminergic precursors on the regulation of gonadal development in birds

Chaturvedi, Chandra Mohini; Yadav, Suneeta

doi:10.1016/j.ygcen.2013.06.019

Cited by 8 publications

(14 citation statements)

References 35 publications

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“…Based on a large number of studies (for a review, see Chaturvedi and Yadav, 2013), it is well established that reproductive regulation involves temporal phase relation of circadian neural oscillations (serotonergic and dopaminergic). Our laboratory has not only substantiated the importance of the temporal phase relation of neurotransmitters in the maturation of the hypothalamohypophyseal-gonadal axis, but has also suggested a possible role of circadian organization/oscillation and their specific phase relation in the modulation of photosexual responses of Japanese quail (Phillips and Chaturvedi, 1995;Chaturvedi et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

Banerjee

Tsutsui

Chaturvedi

2016

Journal of Experimental Biology

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Reproductive performance of many avian species, including Japanese quail, is reported to be modulated by specific temporal phase relation of serotonergic and dopaminergic oscillations. Accordingly, it has been shown that the serotonin precursor 5-HTP and the dopamine precursor L-DOPA given 8 h apart induce gonadal suppression and given 12 h apart lead to gonadal stimulation, while other temporal relationships were found to be ineffective. In the present study, we investigated the effects of 8-and 12-h phase relation of neural oscillations on testicular responses including expression of GnRH-I, GnIH, pro-apoptotic proteins ( p53 and Bax), inactive and active executioner caspase-3, and the uncleaved DNA repair enzyme PARP-1. Testicular volume and mass decreased significantly in 8-h quail and increased in 12-h quail compared with controls. Expression of ir-GnIH, p53, Bax and active-caspase-3 increased and that of GnRH-I, pro-caspase-3 and uncleaved PARP-1 decreased in 8-h quail compared with controls. A TUNEL assay also confirmed testicular regression in these quail. Testes of 12-h quail exhibited significantly increased expression of GnRH-I, pro-caspase-3 and uncleaved PARP-1 compared with the control group. Our findings suggest that differential response of avian testes to 8-and 12-h phase relation of serotonergic and dopaminergic neural oscillations may be attributed to autocrine/paracrine action of GnIH expression, which is upregulated in regressed testes, leading to apoptotic changes, and downregulated in developed testes, causing apoptotic inhibition. It is concluded that specific phase relation of neural oscillations may modulate the local testicular GnRH-GnIH system and alter the apoptotic mechanism in quail testes. Moreover, these findings highlight the physiological effects of time-dependent drug delivery, including the specific time intervals between two drugs.

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Section: Discussionmentioning

confidence: 99%

Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

Banerjee

Tsutsui

Chaturvedi

2016

Journal of Experimental Biology

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“…⁄ p < 0.05, ⁄⁄ p < 0.01, ⁄⁄⁄ p < 0.001; significance of difference from control group. circadian neural oscillations have been reported by several workers (Farner and Follett, 1966;Kumar, 1997;Meier and Martin, 1971;Chaturvedi and Yadav, 2013). However, the synergistic/combined effect of these two factors on gonadal responses was unknown.…”

Section: Discussionmentioning

confidence: 89%

“…In addition to the external factor as the photoperiod, a specific mechanism, i.e., temporal phase relation between serotonergic and dopaminergic oscillations, is also reported to regulate reproduction in many avian species including Japanese quail (Coturnix coturnix japonica) (Chaturvedi and Yadav, 2013;Yadav and Chaturvedi, 2014). A number of studies from our laboratory show that in gene-ral, the serotonin precursor 5-HTP and the dopamine precursor L-DOPA, if given 12 h apart i.e.…”

Section: Introductionmentioning

confidence: 99%

Interaction of specific temporal phase relations of circadian neural oscillations and long term photoperiodic responses in Japanese quail, Coturnix coturnix japonica

Yadav

Chaturvedi

2015

General and Comparative Endocrinology

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“…It has been observed that peaks of serotonin and dopamine rhythms not only occur at different times of the day (Kumar et al, 2009) but it may also vary during different phases of the annual gonadal cycle in Japanese quail (Tiwari, Kumar, Singh, Sharma, & Chaturvedi, 2006). (Chaturvedi & Yadav, 2013;Kumar et al, 2009;Tiwari et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Specific neural phase relation of serotonin and dopamine modulate the testicular activity in Japanese quail

Banerjee

Chaturvedi

2018

Journal Cellular Physiology

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Specific phase relation of serotonin and dopamine modulate the hypothalamo-hypophyseal-gonadal axis as well as photosexual responses in Japanese quail, but the effect of these specific phase relations on testicular activity and steroidogenesis is not yet been investigated. We hypothesized that temporal phase relation induced alteration in local testicular gonadotropin-releasing hormone (GnRH)-Gonadotropin-inhibitory hormone (GnIH) and their receptor system may modulate the testicular activity and steroidogenesis through local (paracrine and autocrine) action. To validate this hypothesis, we have checked the alterations in the expression of gonadotropin-releasing hormone receptor (GnRH-R), gonadotropin-inhibitory hormone receptor (GnIH-R) messenger RNA (mRNA), growth hormone receptor (GH-R), proliferating cell nuclear antigen (PCNA), cell communication and gap junctional proteins (14-3-3 and connexin-43 [Cnx-43]), steroidogenic factor-1 (SF-1), steroidogenic acute regulatory (StAR) protein, steroidogenic enzyme (3β-hydroxysteroid dehydrogenase [3β-HSD]) in testis as well as androgen receptor (AR) in testis and epididymis of control, 8-, and 12-hr quail. Experimental findings clearly indicate the increased expression of GnIH-R mRNA and suppression of GnRH-R, GH-R, PCNA, 14-3-3, Cnx-43, SF-1, StAR, 3β-HSD in testis as well as AR in testis and epididymis in 8-hr quail, while 12-hr quail exhibited the opposite results that is significantly decreased expression of GnIH-R mRNA and increased expression of GnRH-R, GH-R, PCNA, 14-3-3, Cnx-43, SF-1, StAR, 3β-HSD in testis as well as AR in testis and epididymis. The significantly increased intratesticular testosterone has been observed in the 12-hr quail while, 8-hr quail showed opposite result. Hence, it can be concluded that 12-hr quail showed significantly increased testicular activity and steroidogenesis while opposite pattern was observed in 8-hr quail.

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Influence of temporal relationships between serotonergic and dopaminergic precursors on the regulation of gonadal development in birds

Cited by 8 publications

References 35 publications

Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

Apoptosis-mediated testicular alteration in Japanese quail (Coturnix coturnix japonica) in response to temporal phase relation of serotonergic and dopaminergic oscillations

Interaction of specific temporal phase relations of circadian neural oscillations and long term photoperiodic responses in Japanese quail, Coturnix coturnix japonica

Specific neural phase relation of serotonin and dopamine modulate the testicular activity in Japanese quail

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