“…Cleavage of the C-and N-terminal telopeptide (containing the carboxy-and aminoterminal cross-links, respectively [Orgel et al, 2000]) results in the loss of terminal ends of the collagen molecule. The enzymes capable of cleaving telopeptides are collectively called telopeptidases, and in relation to dentin pathologies include at least MMP-2 and MMP-9 [Okada et al, 1995;Garnero et al, 1998Garnero et al, , 2003Osorio et al, 2011], cathepsin K [Garnero et al, 1998[Garnero et al, , 2003], pepsin [Walton et al, 2010] and trypsin [Mirigian et al, 2013]. Type I collagen telopeptide contains recognition sites for the gelatinase fibronectin-like domain [Steffensen et al, 1995], indicating that MMP-2 and MMP-9 telopeptidase activity may be totally separate from the gelatinolytic activity of these enzymes.…”