Matrix Metalloproteinases and Other Matrix Proteinases in Relation to Cariology: The Era of ‘Dentin Degradomics'

Tjäderhane, Leo; Buzalaf, Marília Afonso Rabelo; Carrilho, Marcela Rocha de Oliveira; Miller, Catherine

doi:10.1159/000363582

Cited by 1,615 publications

(149 citation statements)

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“…These materials should ideally be able to provide calcium and phosphate ions for improving tooth remineralization, and nanosize will permit these materials to enter through tooth tissue porosities (Souza et al, 2015). This effect may also be facilitated by the ability of these NPs to inhibit dentin metalloproteinases (Osorio et al, 2014), enzymes implicated in dentinal carious process (Tjäderhane et al, 2015). It has to be ascertained if tested nanoparticles may also offer opportunities to sustain a locally Ca and P-rich environment for the treatment of dental caries.…”

Section: Discussionmentioning

confidence: 99%

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Toledano

Osorio

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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The aim of this study was to evaluate changes in the mechanical and chemical behavior, and bonding ability at dentin interfaces infiltrated with polymeric nanoparticles (NPs) prior to resin application. Dentin surfaces were treated with 37% phosphoric acid followed by application of an ethanol suspension of NPs, Zn-NPs or Ca-NPs followed by the application of an adhesive, Single Bond (SB). Bonded interfaces were stored for 24 h, submitted to microtensile bond strength test, and evaluated by scanning electron microscopy. After 24 h and 21 d of storage, the whole resin-dentin interface adhesive was evaluated using a Nano-DMA. Complex modulus, storage modulus and tan delta (δ) were assessed. AFM imaging and Raman analysis were performed. Bond strength was not affected by NPs infiltration. After 21 d of storage, tan δ generally decreased at Zn-NPs/resin-dentin interface, and augmented when Ca-NPs or non-doped NPs were used. When both Zn-NPs and Ca-NPs were employed, the storage modulus and complex modulus decreased, though both moduli increased at the adhesive and at peritubular dentin after Zn-NPs infiltration. The phosphate and the carbonate peaks, and carbonate substitution, augmented more at interfaces promoted with Ca-NPs than with Zn-NPs after 21 d of storage, but crystallinity did not differ at created interfaces with both ions-doped NPs. Crosslinking of collagen and the secondary structure of collagen improved with Zn-NPs resin-dentin infiltration. Ca-NPs-resin dentin infiltration produced a favorable dissipation of energy with minimal stress concentration trough the crystalline remineralized resin-dentin interface, causing minor damage at this structure.

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Section: Discussionmentioning

confidence: 99%

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Toledano

Osorio

et al. 2017

Journal of the Mechanical Behavior of Biomedical Materials

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“…1,2 The morphological, physiological, and pathological heterogeneity of dentin 3,4 ( Figure 1); limited time available for the procedure; water required to keep the collagen network open for resin penetration 5 ; and limited degree of conversion (rate of polymerization) are the major obstacles to repeatedly achieving uniform dentin bonds. Additionally, hydrolytic (water-related) degradation of both components of the hybrid layer, the collagen matrix and the adhesive resin, seriously compromises the long-term integrity of the adhesive interface and the durability of the bond strength.…”

Section: Introductionmentioning

confidence: 99%

“…4 These changes can significantly reduce dentin mechanical properties, such as hardness, stiffness, tensile strength, modulus of elasticity, and shrinkage during drying, [18][19][20][21] which make the dentin in and under the hybrid layer more prone to cohesive failures under occlusal forces ( Figure 2). Caries demineralization also increases dentin wetness.…”

mentioning

confidence: 99%

“…23,[43][44][45][46][47] Both MMPs and cysteine cathepsins have also been indicated to participate in dentinal caries pathogenesis. 4,35,48-53 MMP-2, -9, and -8 are present in carious dentin, 32,38,45,48 and their activation in pH fluctuations relevant to caries lesions and the role of MMPs in the degradation of dentin collagen have been demonstrated. 48,50 The acidity of the ER 54 and SE 55 adhesives also activates dentinal enzymes.…”

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confidence: 99%

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Dentin Bonding: Can We Make it Last?

Tjäderhane

2015

Operative Dentistry

170

144

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Bond strength to dentin decreases with time because of the hydrolytic degradation of the hybrid layer components dentin collagen and adhesive resin. Inhibition of enzymes responsible for the collagen degradation may improve the bond strength durability. SUMMARYIn dentin bonding, contemporary dental adhesive systems rely on formation of the hybrid layer, a biocomposite containing dentin collagen and polymerized resin adhesive. They are usually able to create at least reasonable integrity of the hybrid layer with high immediate bond strength. However, loss of dentinbonded interface integrity and bond strength is commonly seen after aging both in vitro and in vivo. This is due to endogenous collagenolytic enzymes, matrix metalloproteinases, and cysteine cathepsins, responsible for the timedependent loss of hybrid layer collagen. In addition, the hydrophilic nature of adhesive systems creates problems that lead to suboptimal hybrid layers. These problems include, for example, insufficient resin impregnation of dentin, phase separation, and a low rate of polymerization, all of which may reduce the longevity of the bonded interface.Preservation of the collagen matrix integrity by inhibition of endogenous dentin proteases is key to improving dentin bonding durability. Several approaches to retain the integrity of the hybrid layer and to improve the long-term dentin bond strength have been tested. These include the use of enzyme inhibitors, either separately or as incorporated into the adhesive resins; increase of collagen resistance to enzymatic degradation; and elimination of water from the interface to slow down or eliminate hydrolytic loss of the hybrid layer components. This review looks at the principles, current status, and future of the different techniques designed to prevent the loss of hybrid layer and bond strength.

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“…Only 15 years later, mature human odontoblasts were shown to express MMP-2 and MMP-9. 20,21 Resorption in the crown dentin may be due to these factors. These factors should be investigated in future studies.…”

Section: Discussionmentioning

confidence: 99%

Pre-eruptive Intracoronal Resorption of Dentin in a Permanent Molar: Case Report

Sahin¹,

Yıldız²,

Özbudak³

2015

Turkiye Klinikleri J Dental Sci Cases

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re-eruptive intracoronal resorption (PEIR) is an idiopathic lesion in the crown of an unerupted tooth. 1 PEIR has been described in the literature in sporadic case reports of unerupted teeth with radiolucency in the crown. [2][3][4] In articles, this type of lesion is also called an intracoronal radiolucent lesion, pre-eruptive caries, pre-eruptive intracoronal resorptive lesion, or pre-eruptive intracoronal defect.5-7 PEIR of a tooth looks like a caries lesion. PEIRs are often found within the dentin, adjacent to the amelodentinal junction in the occlusal aspects of the crown. 8,9 These defects have been found generally in a mandibular permanent molar or a maxillary permanent molar during radiographic examination. Pre-eruptive Intracoronal Resorption of Dentin in a Permanent Molar: Case Report A AB BS S T TR RA AC CT T Pre-eruptive coronal resorption (PEIR) appears as a radiolucent lesion in the coronal dentin, under the enamel-dentin junction of unerupted teeth and as caries on radiographs. This case report represents a rare case of PEIR of a semierupted second permanent molar, which was determined by chance on a radiograph of a young patient who was refered to our clinic for the pain complaint of another tooth. Semi-erupted permanent second molar's enamel structure was sound and abnormal pink color was realized. Panoramic and periapical radiographies were examined. The lesion was removed from the tooth after gingival tissue corresponding to the occlusal surface of the tooth was cauterized under regional anesthesia. The soft tissue and enamel fragments were histopathologically examined. This case report contains the diagnosis, histopathologic analysis, management of the lesion, and discussion of the probable etiology.K Ke ey y W Wo or rd ds s: : Tooth Resorption; dentin; dentition Ö ÖZ ZE ET T Sürme öncesinde görülen koronal rezorpsiyon (SÖKR), sürmemiş dişin mine-dentin sınırının altında, koronal dentinde görülen radyolusent lezyonlardır. Radyografik muayenede çürük olarak görülmektedir. Bu olgu raporunda, başka bir dişindeki ağrı şikayeti ile kliniğimize başvuran genç bir hastada radyografik muayenede rastlanan, nadir görülen SÖKR sunulmuştur. Yarı sürmüş daimi ikinci molar dişin mine dokusu sağlam olmakla birlikte anormal pembe renk dikkat çekmiştir. Hastadan ponoramik ve periapikal radyografiler çekilerek değerlendirilmiştir. Dişin distalden oklüzal yüzeyini saran gingival doku bölgesel anestezi altında koterize edilerek kaldırılmıştır. Sağlam mine dokusunun kaldırılmasının ardından lezyon çıkartılarak histopatolojik değerlendirme için gönde-rilmiştir. Bu olgu sunumunda, vakanın teşhisi, histopatolojik analizi, lezyonun tedavisi ve olası etiyolojik faktörler anlatılmıştır.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Diş rezorpsiyonu; dentin; diş çıkarma T Tu ur rk ki iy ye e K Kl li in ni ik kl le er ri i J J D De en nt ta al l S Sc ci i C Ca as se es s 2 20 01 15 5; ;1 1( (4 4) ): :2 23 37 7--4 41 1

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Matrix Metalloproteinases and Other Matrix Proteinases in Relation to Cariology: The Era of ‘Dentin Degradomics'

Cited by 1,615 publications

References 149 publications

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Ions-modified nanoparticles affect functional remineralization and energy dissipation through the resin-dentin interface

Dentin Bonding: Can We Make it Last?

Pre-eruptive Intracoronal Resorption of Dentin in a Permanent Molar: Case Report

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