Influence of tDCS over right inferior frontal gyrus and pre-supplementary motor area on perceptual decision-making and response inhibition: A healthy ageing perspective

Fujiyama, Hakuei; Tan, Jane; Puri, Rohan; Hinder, Mark R.

doi:10.1016/j.neurobiolaging.2021.09.014

Cited by 10 publications

(7 citation statements)

References 76 publications

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“…In addition, the placement of electrodes might also lead to inconsistency because the anode electrode was placed over C2 in the present study, and the center of the pad electrode was put over Fz (Yu et al, 2015) or 4 cm anterior to Cz (Kwon and Kwon, 2013a,b) in previous studies. On the other hand, the absence of improvement in SSRT is consistent with the results of some other studies (Bender et al, 2017;Fujiyama et al, 2021), suggesting that more studies are needed to figure out the effect of anodal tDCS over the pre-SMA.…”

Section: Discussionsupporting

confidence: 89%

“…First, the participants were all young healthy adults in our study; consequently, the results should be cautiously generalized to other groups with different ages. Considering neural anatomical differences, the effect of tDCS over the rIFG and pre-SMA on response inhibition has been shown to be agedependent (Fujiyama et al, 2021), so future studies are warranted to further elucidate age-related differences in the results of tDCS application. Second, there was no followup assessment and thus the sustainability of the effects of multitarget tDCS remains unclear; this is a vital issue for the use of tDCS in practical applications.…”

Section: Discussionmentioning

confidence: 99%

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Multitarget high-definition transcranial direct current stimulation improves response inhibition more than single-target high-definition transcranial direct current stimulation in healthy participants

et al. 2022

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Prior studies have focused on single-target anodal transcranial direct current stimulation (tDCS) over the right inferior frontal gyrus (rIFG) or pre-supplementary motor area (pre-SMA) to improve response inhibition in healthy individuals. However, the results are contradictory and the effect of multitarget anodal stimulation over both brain regions has never been investigated. The present study aimed to investigate the behavioral and neurophysiological effects of different forms of anodal high-definition tDCS (HD-tDCS) on improving response inhibition, including HD-tDCS over the rIFG or pre-SMA and multitarget HD-tDCS over both areas. Ninety-two healthy participants were randomly assigned to receive single-session (20 min) anodal HD-tDCS over rIFG + pre-SMA, rIFG, pre-SMA, or sham stimulation. Before and immediately after tDCS intervention, participants completed a stop-signal task (SST) and a go/nogo task (GNG). Their cortical activity was recorded using functional near-infrared spectroscopy (fNIRS) during the go/nogo task. The results showed multitarget stimulation produced a significant reduction in stop-signal reaction time (SSRT) relative to baseline. The pre-to-post SSRT change was not significant for rIFG, pre-SMA, or sham stimulation. Further analyses revealed multitarget HD-tDCS significantly decreased SSRT in both the high-performance and low-performance subgroups compared with the rIFG condition which decreased SSRT only in the low-performance subgroup. Only the multitarget condition significantly improved neural efficiency as indexed by lower △oxy-Hb after stimulation. In conclusion, the present study provides important preliminary evidence that multitarget HD-tDCS is a promising avenue to improve stimulation efficacy, establishing a more effective montage to enhance response inhibition relative to the commonly used single-target stimulation.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 99%

Multitarget high-definition transcranial direct current stimulation improves response inhibition more than single-target high-definition transcranial direct current stimulation in healthy participants

et al. 2022

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“…In particular, response bias was signi cantly associated with the volume of the middle temporal gyrus, a region associated with processing e ciency and effective stimulus discrimination 54,55 . Next, increased evidence accumulation (towards No-Go) being associated with greater inferior frontal gyrus integrity is congruent with work showing that the parameter is sensitive to aging on perceptual decision-making tasks 19 , and research describing correlational 56 and causal links 57 between the inferior frontal gyrus and inhibitory control.…”

Section: Discussionsupporting

confidence: 73%

“…Imaging data were subjected to both whole-brain and region-of-interest (ROI) analyses. To understand brain-Go/No-Go performance relationships we de ned the following ROIs: bilateral insula 56 , inferior frontal gyrus 56 , supplementary motor area (SMA) 57,123 . For the WCST, the ROIs comprised the bilateral prefrontal cortex (PFC) 12 and dorsolateral (PFC) 124 .…”

Section: Mri Protocolmentioning

confidence: 99%

Mapping Computational Cognitive Profiles of Aging to Dissociable Brain and Sociodemographic Factors

Marzuki,

Wong,

Chan

et al. 2024

Preprint

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Aging is associated with declines in cognition and brain structural integrity. However, there is equivocality over 1) the specificity of affected domains in different people, 2) the location of associated patterns of brain structural deterioration, and 3) the sociodemographic factors contributing to ‘unhealthy’ cognition. We aimed to identify cognitive profiles displayed by older adults and determine brain and sociodemographic features potentially shaping these profiles. A sample of Southeast-Asian older adults (N = 386) participated in a multi-session study comprising cognitive testing, neuroimaging, and a structured interview. We used computational models to extract latent mechanisms underlying cognitive flexibility and response inhibition. Data-driven methods were used to construct cognitive profiles based on standard performance measures and model parameters. We also investigated grey matter volume and machine-learning derived ‘brain-ages’. A profile associated with poor set-shifting and rigid focusing was associated with widespread grey matter reduction in cognitive control regions. A slow responding profile was associated with advanced brain-age. Both profiles were correlated with poor socioeconomic standing and cognitive reserve. This study furthers understanding of how distinct aging profiles of cognitive impairment uniquely correspond to specific vs. global brain deterioration and the significance of socioeconomic factors in informing cognitive performance in older age.

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“…It is a suitable tool to infer the causality for the links between brain function and corresponding behavioral changes ( Filmer et al, 2014 ; Gbadeyan et al, 2016 ; Yavari et al, 2018 ). tDCS is safe, non-invasive, tolerable, and easy-to-operate ( Bikson et al, 2016 ) and has been found to effectively enhance response inhibition via anodal stimulation targeting rIFG or pre-SMA ( Hsu et al, 2011 ; Jacobson et al, 2011 ; Ditye et al, 2012 ; Kwon and Kwon, 2013b , a ; Stramaccia et al, 2015 ; Sandrini et al, 2020 ; Fujiyama et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Long-term effects of repeated multitarget high-definition transcranial direct current stimulation combined with cognitive training on response inhibition gains

Guo

Qiu²,

Qiu³

et al. 2023

Front. Neurosci.

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BackgroundFew studies have investigated the effects of repeated sessions of transcranial direct current stimulation (tDCS) combined with concurrent cognitive training on improving response inhibition, and the findings have been heterogeneous in the limited research. This study investigated the long-lasting and transfer effects of 10 consecutive sessions of multitarget anodal HD-tDCS combined with concurrent cognitive training on improving response inhibition compared with multitarget stimulation or training alone.MethodsNinety-four healthy university students aged 18–25 were randomly assigned to undergo different interventions, including real stimulation combined with stop-signal task (SST) training, real stimulation, sham stimulation combined with SST training, and sham stimulation. Each intervention lasted 20 min daily for 10 consecutive days, and the stimulation protocol targeted right inferior frontal gyrus (rIFG) and pre-supplementary motor area (pre-SMA) simultaneously with a total current intensity of 2.5 mA. Performance on SST and possible transfer effects to Stroop task, attention network test, and N-back task were measured before and 1 day and 1 month after completing the intervention course.ResultsThe main findings showed that the combined protocol and the stimulation alone significantly reduced stop-signal reaction time (SSRT) in the post-intervention and follow-up tests compared to the pre-intervention test. However, training alone only decreased SSRT in the post-test. The sham control exhibited no changes. Subgroup analysis revealed that the combined protocol and the stimulation alone induced a decrease in the SSRT of the low-performance subgroup at the post-test and follow-up test compared with the pre-test. However, only the combined protocol, but not the stimulation alone, improved the SSRT of the high-performance subgroup. The transfer effects were absent.ConclusionThis study provides supportive evidence for the synergistic effect of the combined protocol, indicating its superiority over the single intervention method. In addition, the long-term after-effects can persist for up to at least 1 month. Our findings also provide insights into the clinical application and strategy for treating response inhibition deficits.

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Influence of tDCS over right inferior frontal gyrus and pre-supplementary motor area on perceptual decision-making and response inhibition: A healthy ageing perspective

Cited by 10 publications

References 76 publications

Multitarget high-definition transcranial direct current stimulation improves response inhibition more than single-target high-definition transcranial direct current stimulation in healthy participants

Multitarget high-definition transcranial direct current stimulation improves response inhibition more than single-target high-definition transcranial direct current stimulation in healthy participants

Mapping Computational Cognitive Profiles of Aging to Dissociable Brain and Sociodemographic Factors

Long-term effects of repeated multitarget high-definition transcranial direct current stimulation combined with cognitive training on response inhibition gains

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