Multitarget high-definition transcranial direct current stimulation improves response inhibition more than single-target high-definition transcranial direct current stimulation in healthy participants

Guo, Zhiqi; Gong, Yue; Lü, Hongliang; Qiu, Rui; Wang, Xinlu; Xia, Zhenzhen; You, Xuqun

doi:10.3389/fnins.2022.905247

Cited by 7 publications

(14 citation statements)

References 114 publications

(135 reference statements)

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“…Additionally, we found that the repeated sessions of multitarget stimulation or SST training alone could improve response inhibition compared with the sham control condition, consistent with our hypothesis. The favorable effect of multitarget stimulation over sham control on response inhibition is in line with our previous study (Guo et al, 2022a). It is also similar to published studies indicating that multitarget stimulation exerted more significant effects on motor function than sham control (Dagan et al, 2018).…”

Section: Discussionsupporting

confidence: 92%

“…Multitarget HD-tDCS was delivered using an M × N-9 HD-tES Stimulator (Soterix Medical, Inc., New York, NY, USA), following the procedures for HD-tDCS usage specified in a previous study protocol ( Villamar et al, 2013 ). The stimulation procedure in this study used multitarget HD-tDCS on rIFG and pre-SMA from our previous study ( Guo et al, 2022a ). The electrodes were localized according to the international 10-10 EEG system ( Jurcak et al, 2007 ).…”

Section: Methodsmentioning

confidence: 99%

“…We used SST to evaluate the response inhibition performance ( Logan et al, 1984 ; Verbruggen and Logan, 2008 ; Verbruggen et al, 2019 ). The task settings were identical to our previous study ( Guo et al, 2022a ). In the pre-potent go trials (75% of total trials), the participants were instructed to discriminate the direction of the right arrow or left arrow go signal on the screen by pressing the corresponding key (F for the left arrow and J for the right arrow) on a standard keyboard as quickly and accurately as possible.…”

Section: Methodsmentioning

confidence: 99%

“…High-definition tDCS (HD-tDCS) is an optimized form of conventional pad-tDCS with high spatial precision and produces more prominent behavioral and neurophysiological effects ( Kuo et al, 2013 ; Sehatpour et al, 2021 ). Multitarget stimulation refers to simultaneous stimulation with the same polarity on multiple functionally related brain cortices, which can modulate the cortical activity more efficiently and enhance tDCS effects more prominently than conventional single-target stimulation ( Hill et al, 2018 ; Gregoret et al, 2021 ; Guo et al, 2022a ). Given behavioral and neuroimaging evidence, a previous study has shown that multitarget high-definition stimulation of rIFG and pre-SMA is more effective in improving response inhibition compared with the commonly used single-target stimulation on rIFG or pre-SMA alone ( Guo et al, 2022a ).…”

Section: Introductionmentioning

confidence: 99%

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Long-term effects of repeated multitarget high-definition transcranial direct current stimulation combined with cognitive training on response inhibition gains

Guo

Qiu²,

Qiu³

et al. 2023

Front. Neurosci.

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BackgroundFew studies have investigated the effects of repeated sessions of transcranial direct current stimulation (tDCS) combined with concurrent cognitive training on improving response inhibition, and the findings have been heterogeneous in the limited research. This study investigated the long-lasting and transfer effects of 10 consecutive sessions of multitarget anodal HD-tDCS combined with concurrent cognitive training on improving response inhibition compared with multitarget stimulation or training alone.MethodsNinety-four healthy university students aged 18–25 were randomly assigned to undergo different interventions, including real stimulation combined with stop-signal task (SST) training, real stimulation, sham stimulation combined with SST training, and sham stimulation. Each intervention lasted 20 min daily for 10 consecutive days, and the stimulation protocol targeted right inferior frontal gyrus (rIFG) and pre-supplementary motor area (pre-SMA) simultaneously with a total current intensity of 2.5 mA. Performance on SST and possible transfer effects to Stroop task, attention network test, and N-back task were measured before and 1 day and 1 month after completing the intervention course.ResultsThe main findings showed that the combined protocol and the stimulation alone significantly reduced stop-signal reaction time (SSRT) in the post-intervention and follow-up tests compared to the pre-intervention test. However, training alone only decreased SSRT in the post-test. The sham control exhibited no changes. Subgroup analysis revealed that the combined protocol and the stimulation alone induced a decrease in the SSRT of the low-performance subgroup at the post-test and follow-up test compared with the pre-test. However, only the combined protocol, but not the stimulation alone, improved the SSRT of the high-performance subgroup. The transfer effects were absent.ConclusionThis study provides supportive evidence for the synergistic effect of the combined protocol, indicating its superiority over the single intervention method. In addition, the long-term after-effects can persist for up to at least 1 month. Our findings also provide insights into the clinical application and strategy for treating response inhibition deficits.

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Section: Discussionsupporting

confidence: 92%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Long-term effects of repeated multitarget high-definition transcranial direct current stimulation combined with cognitive training on response inhibition gains

Guo

Qiu²,

Qiu³

et al. 2023

Front. Neurosci.

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“…A multitarget HD-tDCS study concurrently targeted the right IFG and the pre-supplementary motor area (pre-SMA) and stimulated these brain regions individually for comparison. Results indicate that the combined stimulation of both regions led to improved inhibitory control, while no such improvement was observed when stimulating one single brain region 52 . Here, we tested the impact of net-tDCS optimized to modulate regions important for appetite control, which included parts of the dlPFC, vmPFC, IFG as well as limbic regions important for reward processes and decision making.…”

Section: Discussionmentioning

confidence: 81%

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study

Ester-Nacke,

Berti,

Veit

et al. 2024

Sci Rep

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The hypothalamus is the key regulator for energy homeostasis and is functionally connected to striatal and cortical regions vital for the inhibitory control of appetite. Hence, the ability to non-invasively modulate the hypothalamus network could open new ways for the treatment of metabolic diseases. Here, we tested a novel method for network-targeted transcranial direct current stimulation (net-tDCS) to influence the excitability of brain regions involved in the control of appetite. Based on the resting-state functional connectivity map of the hypothalamus, a 12-channel net-tDCS protocol was generated (Neuroelectrics Starstim system), which included anodal, cathodal and sham stimulation. Ten participants with overweight or obesity were enrolled in a sham-controlled, crossover study. During stimulation or sham control, participants completed a stop-signal task to measure inhibitory control. Overall, stimulation was well tolerated. Anodal net-tDCS resulted in faster stop signal reaction time (SSRT) compared to sham (p = 0.039) and cathodal net-tDCS (p = 0.042). Baseline functional connectivity of the target network correlated with SSRT after anodal compared to sham stimulation (p = 0.016). These preliminary data indicate that modulating hypothalamus functional network connectivity via net-tDCS may result in improved inhibitory control. Further studies need to evaluate the effects on eating behavior and metabolism.

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A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits

Chiang,

Mudar,

Dugas

et al. 2024

Brain and Behavior

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Word finding difficulty is a frequent complaint in older age and disease states, but treatment options are lacking for such verbal retrieval deficits. Better understanding of the neurophysiological and neuroanatomical basis of verbal retrieval function may inform effective interventions. In this article, we review the current evidence of a neural retrieval circuit central to verbal production, including words and semantic memory, that involves the pre‐supplementary motor area (pre‐SMA), striatum (particularly caudate nucleus), and thalamus. We aim to offer a modified neural circuit framework expanded upon a memory retrieval model proposed in 2013 by Hart et al., as evidence from electrophysiological, functional brain imaging, and noninvasive electrical brain stimulation studies have provided additional pieces of information that converge on a shared neural circuit for retrieval of memory and words. We propose that both the left inferior frontal gyrus and fronto‐polar regions should be included in the expanded circuit. All these regions have their respective functional roles during verbal retrieval, such as selection and inhibition during search, initiation and termination of search, maintenance of co‐activation across cortical regions, as well as final activation of the retrieved information. We will also highlight the structural connectivity from and to the pre‐SMA (e.g., frontal aslant tract and fronto‐striatal tract) that facilitates communication between the regions within this circuit. Finally, we will discuss how this circuit and its correlated activity may be affected by disease states and how this circuit may serve as a novel target engagement for neuromodulatory treatment of verbal retrieval deficits.

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Multitarget high-definition transcranial direct current stimulation improves response inhibition more than single-target high-definition transcranial direct current stimulation in healthy participants

Cited by 7 publications

References 114 publications

Long-term effects of repeated multitarget high-definition transcranial direct current stimulation combined with cognitive training on response inhibition gains

Long-term effects of repeated multitarget high-definition transcranial direct current stimulation combined with cognitive training on response inhibition gains

Network-targeted transcranial direct current stimulation of the hypothalamus appetite-control network: a feasibility study

A modified neural circuit framework for semantic memory retrieval with implications for circuit modulation to treat verbal retrieval deficits

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