Influence of Surgical Complications on Kidney Graft Survival in Recipients of Simultaneous Pancreas Kidney Transplantation

Campos-Hernández, J.P.; Gómez, Enrique Gómez; Carrasco‐Valiente, Julia; López, Ferran Campillo i; García, Jesús Ruiz; Curado, F.J. Anglada; Castro, Rafael Prieto; Rabelo, J. Ruiz; Cabello, Mercedes; Tapia, M.J. Requena

doi:10.1016/j.transproceed.2014.12.010

Cited by 8 publications

(4 citation statements)

References 20 publications

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“…44 Overall, the 1-year survival rate for the kidney graft was over 90%. 7,44,45 The 10-year and 20-year kidney survival rates were 63% and 38%, respectively. 7 In terms of overall mortality, the most common causes following SPK have been reported to be cardiopulmonary (7.2%), followed by infection (3.4%), stroke (1.8%), and renal failure (1.5%).…”

Section: Complications Of Simultaneous Pancreas and Kidney Transplantmentioning

confidence: 99%

Simultaneous pancreas and kidney transplantation as the standard surgical treatment for diabetes mellitus patients with end-stage renal disease

et al. 2016

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Objectives: To review the outcome following simultaneous pancreas and kidney transplantation in patients with type 1 diabetes mellitus and endstage renal disease, as well as those with type 2 diabetes mellitus, and to discuss the applicability of this treatment in this locality. Methods:A systematic literature review was performed by searching the PubMed and Elsevier databases. The search terms used were "simultaneous pancreas and kidney transplantation", "diabetes", "pancreas transplant" and "SPK". Original and major review articles related to simultaneous pancreas and kidney transplantation were reviewed. Papers published in English after 1985 were included. Clinical outcomes following transplantation were extracted for comparison between different treatment methods. Outcomes of simultaneous pancreas and kidney transplant and other transplantation methods were identified and categorised into patient survival, graft survival, diabetic complications, and quality of life. Patient survivals and graft survivals were also compared. Results

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Section: Complications Of Simultaneous Pancreas and Kidney Transplantmentioning

confidence: 99%

Simultaneous pancreas and kidney transplantation as the standard surgical treatment for diabetes mellitus patients with end-stage renal disease

et al. 2016

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“…Banga et al (7) found that patients with major complications during the first three months had decreased five-year pancreas survival (74% vs. 82%, p=0.027), but no differences were found in kidney survival (82% vs. 83% p=0.412). On the other hand, Campos-Hernandez et al (12) found decreased five-year kidney graft survival among patients who had Clavien-Dindo ≥IIIb complications (81.8% vs. 97.3%, p=0.001). Similar results were found by Manrique et al ( 9) and Steurer et al (10).…”

confidence: 97%

“…SPKT can also be performed in selected patients with type 2 DM with similar results to type 1 patients (4), although the 2020 KDIGO guideline only recommended it for type 1 DM, with no suggestions for type 2 DM (5). SPKT has an extremely high rate of surgical complications and surgical-related mortality (6)(7)(8)(9)(10)(11)(12). Although there is a trend towards lower complications rates after SPKT (6), most series report relaparotomy rates that vary from 23% (7) to a 57% (6).…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous pancreas-kidney transplantation: Early complications and long-term outcomes – a single-centre experience

Crespo

Cubillana

González

et al. 2022

CUAJ

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Introduction: This study aimed to assess the prevalence and severity of complications after simultaneous pancreas-kidney transplantation (SPKT) and to evaluate its influence on both grafts’ long-term results. Methods: This was an observational, retrospective study including 39 consecutive SPKT cases from 2000–2018. Complications were classified into kidney-related and pancreas-related. The severity of complications was assessed using the modified Clavien-Dindo scale. Kaplan-Meier curve analysis and log-rank tests were used. Cox regression was performed for the multivariate analysis. Results: All 39 recipients had long-term type I diabetes. Twenty-one (53.8%) patients suffered a Clavien-Dindo ≥IIIa complication. Most complications were pancreas-related, with 17 (43.6%) patients suffering from one. Kidney-related major complications were seen in 11 (28.2%) patients. Patient survival at one, five, and 15 years was 89.7%, 87.1%, and 83.9%, respectively; kidney survival was 87.1%, 81.4%, and 73.6%, respectively; and pancreas survival was 76.9%, 71.3%, and 72%, respectively. Pancreas graft survival was influenced by the presence of major postoperative complications; patients and kidney graft survival were not. Conclusions: Complications after SPKT influence pancreas graft survival. Despite the high rate of complications, our results suggest that patients' and kidney graft survival may not be affected by complications.

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The ripple effect of a complication in lung transplantation: Evidence for increased long-term survival risk

Chan

Bianco

Richards

et al. 2016

The Journal of Thoracic and Cardiovascular Surgery

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Influence of Surgical Complications on Kidney Graft Survival in Recipients of Simultaneous Pancreas Kidney Transplantation

Cited by 8 publications

References 20 publications

Simultaneous pancreas and kidney transplantation as the standard surgical treatment for diabetes mellitus patients with end-stage renal disease

Simultaneous pancreas and kidney transplantation as the standard surgical treatment for diabetes mellitus patients with end-stage renal disease

Simultaneous pancreas-kidney transplantation: Early complications and long-term outcomes – a single-centre experience

The ripple effect of a complication in lung transplantation: Evidence for increased long-term survival risk

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