Influence of surface pre-treatment on the cytocompatibility of a novel biodegradable ZnMg alloy

Jablonská, Eva; Vojtěch, Dalibor; Fousová, Michaela; Kubásek, Jiří; Lipov, Jan; Fojt, Jaroslav; Ruml, Tomáš

doi:10.1016/j.msec.2016.05.114

Cited by 53 publications

(53 citation statements)

References 22 publications

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“…The coating was applied by a simple dip coating method, and coating thickness was controlled by adjusting withdrawal speed and PLLA concentration. Jablonska et al [97] confirmed the reduction of the corrosion rate of Zn after a surface pre-treatment that involved immersion of the metal in simulated body fluid (SBF) for a prolonged period.…”

Section: Advanced Processing Techniquesmentioning

confidence: 94%

“…The above reactions show that, aside from Zn, different elements reside in the corrosion product including P, H, O, and Cl [18,19,55,92,94,99,123]. The presence of Ca and C has also been reported in the product layer, as zinc (calcium) phosphates, smithsonite or zinc carbonate (ZnCO 3 ), or bicarbonates [18,19,97,107,116,117,146] [82,104,107,126,163]. The presence of these compounds can vary along the thickness of the corrosion film.…”

Section: Corrosion Mechanism Of Zn In a Physiological Environmentmentioning

confidence: 97%

“…Development of binary Zn alloys continued with notable works by Zheng and co-workers [87,88] on Zn-Mg, as well as zinc-calcium (Zn-Ca), and zincstrontium (Zn-Sr) alloys. Other reports on Zn-Mg include those by Kubasek et al [55,89,90], Yao et al [91],Gong et al [92], Murni et al [93], Shen et al [94], Galib and Sharif [95], Mostaed et al [96], Jablonska et al [97], Dambatta et al [98,99], Vida et al [100], Jarzebska et al [101], Jin et al [102], Xiao et al [103], Alves et al [104], Wang et al [105], and Yang et al [78]. The range of Mg addition typically ranged from 1 to 3 wt%; though relatively high (>5%) [90] and low (<0.1 wt%) [102,103] alloy additions of Mg have also been reported.…”

Section: Binary Alloysmentioning

confidence: 99%

“…Numerous in vitro cytocompatibility [55,78,[92][93][94]97,103] and hemocompatibility [87,94] studies have put forth enough evidences proving the good biocompatibility of different Zn-xMg alloys (x = 0.05, 0.8, 1.0, 1.2, 1.5, 2, 3, 4). Similar to reports on Zn, some Zn-Mg alloys [55,93,103] have also been reported to trigger cytotoxic responses in cells exposed to 100% extract concentrations; though this could be attributed to the perceived incompatibility of the current testing standard (i.e., ISO 10993) to biodegradable metals.…”

Section: Influence Of Alloyingmentioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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Zinc has been identified as one of the most promising biodegradable metals along with magnesium and iron. Zinc appears to address some of the core engineering problems associated with magnesium and iron when applied to biomedical implant applications; hence the increase in the amount of research investigations on the metal in the last few years. In this review, the current state-of-the-art on biodegradable Zn, including recent developments, current opportunities and future directions of research are discussed. The discussions are presented with a specific focus on reviewing the relationships that exist between mechanical properties, biodegradability, and biocompatibility of zinc with alloying and fabrication techniques. This work hopes to guide future studies on biodegradable Zn that will help in advancing this field of research. Statement of Significance (i) The review offers an up-to-date and comprehensive review of the influence of alloying and fabrication technique on mechanical properties, biodegradability and biocompatibility of Zn; (ii) the work cites the most relevant biodegradable Zn fabrication processes including additive manufacturing techniques; (iii) the review includes a listing of research gap and future research directions for the field of biodegradable Zn.

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Section: Advanced Processing Techniquesmentioning

confidence: 94%

Section: Corrosion Mechanism Of Zn In a Physiological Environmentmentioning

confidence: 97%

Section: Binary Alloysmentioning

confidence: 99%

Section: Influence Of Alloyingmentioning

confidence: 99%

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The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

2019

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“…Alloys of Zn-Mg alloys are also of interest but have previously been considered primarily for orthopedic applications [23,24]. Zn-1Mg, Zn-1Ca, and Zn-1Sr alloys have corrosion rates between 0.08-0.12 mm year −1 in Hank's solution [25], which are lower than most Mg alloys.…”

Section: Introductionmentioning

confidence: 99%

In Vitro and In Vivo Testing of Zinc as a Biodegradable Material for Stents Fabricated by Photo-Chemical Etching

et al. 2019

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There is an increasing interest in biodegradable metal implants made from magnesium (Mg), iron (Fe), zinc (Zn) and their alloys because they are well tolerated in vivo and have mechanical properties that approach those of non-degradable metals. In particular, Zn and its alloys show the potential to be the next generation of biodegradable materials for medical implants. However, Zn has not been as well-studied as Mg, especially for stent applications. Manufacturing stents by laser cutting has become an industry standard. Nevertheless, the use of this approach with Zn faces some challenges, such as generating thermal stress, dross sticking on the device, surface oxidation, and the need for expensive thin-walled Zn tubing and post-treatment. All of these challenges motivated us to employ photo-chemical etching for fabricating different designs of Zn (99.95% pure) stents. The stents were constructed with different strut patterns, made by photo-chemical etching, and mechanically tested to evaluate radial forces. Stents with rhombus design patterns showed a promising 0.167N/mm radial force, which was comparable to Mg-based stents. In vitro studies were conducted with uncoated Zn stents as control and Parylene C-coated Zn stents to determine corrosion rates. The Parylene C coating reduced the corrosion rate by 50% compared to uncoated stents. In vivo studies were carried out by implanting photo-chemically etched, uncoated Zn stent segments subcutaneously in a C57BL/6 mice model. Histological analyses provided favorable data about the surrounding tissue status, as well as nerve and blood vessel responses near the implant, providing insights into the in vivo degradation of the metal struts. All of these experiments confirmed that Zn has the potential for use in biodegradable stent applications.

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The Prospects for Biodegradable Zinc in Wound Closure Applications

Venezuela

Johnston

Dargusch

2019

Adv Healthcare Materials

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Zinc is identified as a promising biodegradable metal along with magnesium and iron. In the last five years, considerable progress has been made on understanding the mechanical properties, biodegradability, and biocompatibility of zinc and its alloys. A majority of these studies focused on using zinc for absorbable cardiovascular and orthopedic device applications. However, it is likely that zinc is also suitable for other biomedical applications.In this work, the prospects for zinc in the fabrication of wound closure devices such as absorbable sutures, staples, and surgical tacks are critically assessed, with the aim of inspiring future research on biodegradable Zn for this medical application.

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Influence of surface pre-treatment on the cytocompatibility of a novel biodegradable ZnMg alloy

Cited by 53 publications

References 22 publications

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

The influence of alloying and fabrication techniques on the mechanical properties, biodegradability and biocompatibility of zinc: A comprehensive review

In Vitro and In Vivo Testing of Zinc as a Biodegradable Material for Stents Fabricated by Photo-Chemical Etching

The Prospects for Biodegradable Zinc in Wound Closure Applications

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