Influence of surface charge and inner composition of porous nanoparticles to cross blood–brain barrier in vitro

Jallouli, Youssef; Paillard, Archibald; Chang, Jiang; Sevin, Emmanuel; Betbeder, Didier

doi:10.1016/j.ijpharm.2007.06.023

Cited by 127 publications

(70 citation statements)

References 25 publications

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“…In the study by Jallouli et al 47 the uptake of 60 nm neutral and cationic maltodextrin porous NPs with a phospholipid core was investigated in brain capillary endothelial cells. Neutral NPs were endocytosed in the caveolae-mediated pathway, while the cationic NPs were found to utilize the paracellular pathway due to the rich anionic sites found on the luminal surface of the endothelial cells.…”

Section: Cationic and Neutral Nanoparticlesmentioning

confidence: 99%

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures

Murugan¹,

Choonara²,

Kumar³

et al. 2015

IJN

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Cellular internalization and trans-barrier transport of nanoparticles can be manipulated on the basis of the physicochemical and mechanical characteristics of nanoparticles. Research has shown that these factors significantly influence the uptake of nanoparticles. Dictating these characteristics allows for the control of the rate and extent of cellular uptake, as well as delivering the drug-loaded nanosystem intra-cellularly, which is imperative for drugs that require a specific cellular level to exert their effects. Additionally, physicochemical characteristics of the nanoparticles should be optimal for the nanosystem to bypass the natural restricting phenomena of the body and act therapeutically at the targeted site. The factors at the focal point of emerging smart nanomedicines include nanoparticle size, surface charge, shape, hydrophobicity, surface chemistry, and even protein and ligand conjugates. Hence, this review discusses the mechanism of internalization of nanoparticles and ideal nanoparticle characteristics that allow them to evade the biological barriers in order to achieve optimal cellular uptake in different organ systems. Identifying these parameters assists with the progression of nanomedicine as an outstanding vector of pharmaceuticals.

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Section: Cationic and Neutral Nanoparticlesmentioning

confidence: 99%

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures

Murugan¹,

Choonara²,

Kumar³

et al. 2015

IJN

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“…It was shown that filipin can increase the binding and uptake (sterols may entail in their efflux), while decrease the transcytosis of neutral NPs. They concluded that the neutral NPs, like LDL, exploit the caveolae pathway and suggested the neutral and cationic 60 nm porous NPs as potential candidates for drug delivery to the brain (Jallouli et al, 2007). It is believed that Tf receptor, as a molecular part of vesicular trafficking, can facilitate brain delivery of NPs in vivo.…”

Section: Macromolecular Permeationmentioning

confidence: 99%

Blood-Brain Barrier and Effectiveness of Therapy Against Brain Tumors

Omidi¹,

Barar²

2012

Novel Therapeutic Concepts in Targeting Glioma

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“…The nanoparticles inhaled can gain access to the brain by means of two different mechanisms, namely, transsynaptic transport after inhalation through the olfactory epithelium and uptake through the blood-brain barrier [62,63]. A number of pathologies, including hypertension and allergic encephalomyelitis, however have been associated with increased permeability of the blood brain barrier to nanoparticles in experimental setups.…”

Section: Central Nervous Systemmentioning

confidence: 99%

Nanotoxicity: Dimensional and Morphological Concerns

Wani

Hashim

Nabi

et al. 2011

Advances in Physical Chemistry

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Nanotechnology deals with the construction of new materials, devices, and different technological systems with a wide range of potential applications at the atomic and molecular level. Nanomaterials have attracted great attention for numerous applications in chemical, biological, and industrial world because of their fascinating physicochemical properties. Nanomaterials and nanodevices are being produced intentionally, unintentionally, and manufactured or engineered by different methods and released into the environment without any safety test. Nantoxicity has become the subject of concern in nanoscience and nanotechnology because of the increasing toxic effects of nanomaterials on the living organisms. Nanomaterials can move freely as compared to the largesized particles; therefore, they can be more toxic than bulky materials. This review article delineates the toxic effects of different types of nanomaterials on the living organisms through different sources, like water, air, contact with skin, and the methods of determinations of these toxic effects.

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Influence of surface charge and inner composition of porous nanoparticles to cross blood–brain barrier in vitro

Cited by 127 publications

References 25 publications

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures

Blood-Brain Barrier and Effectiveness of Therapy Against Brain Tumors

Nanotoxicity: Dimensional and Morphological Concerns

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Influence of surface charge and inner composition of porous nanoparticles to cross blood–brain barrier in vitro

Cited by 127 publications

References 25 publications

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of&nbsp;nanostructures

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of&nbsp;nanostructures

Blood-Brain Barrier and Effectiveness of Therapy Against Brain Tumors

Nanotoxicity: Dimensional and Morphological Concerns

Contact Info

Product

Resources

About

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures

Parameters and characteristics governing cellular internalization and trans-barrier trafficking of nanostructures