Nanotoxicity: Dimensional and Morphological Concerns

Wani, Mohmmad Younus; Hashim, Mohd Ali; Nabi, Firdosa; Malik, Maqsood Ahmad

doi:10.1155/2011/450912

Cited by 69 publications

(47 citation statements)

References 160 publications

(192 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although nano-silver was known to be harmless, recent studies (Asare, et al, 2012;Foldbjerg, Dang, & Autrup, 2011;Hussain, et al, 2006;Kim, et al, 2009) have provided convincing evidence of toxicity associated with the exposure to nano-silver. More detailed information about the potential adverse effects of various NMs has been provided by several researchers (Arora, et al, 2012;Holgate, 2010;Horie & Fujita, 2011;Jeng & Swanson, 2006;Magrez, et al, 2006;Saquib, et al, 2012;Sharifi, et al, 2012;Wani, Hashim, Nabi, & Malik, 2011).…”

Section: Nanomaterials Toxicitymentioning

confidence: 99%

(Q)SAR modelling of nanomaterial toxicity: A critical review

et al. 2015

View full text Add to dashboard Cite

There is an increasing recognition that nanomaterials pose a risk to human health, and that the novel engineered nanomaterials (ENMs) in the nanotechnology industry and their increasing industrial usage poses the most immediate problem for hazard assessment, as many of them remain untested. The large number of materials and their variants (different sizes and coatings for instance) that require testing and ethical pressure towards non-animal testing means that expensive animal bioassay is precluded, and the use of (quantitative) structure activity relationships ((Q)SAR) models as an alternative source of hazard information should be explored.(Q)SAR modelling can be applied to fill the critical knowledge gaps by making the best use of existing data, prioritize physicochemical parameters driving toxicity, and provide practical solutions to the risk assessment problems caused by the diversity of ENMs. This paper covers the core components required for successful application of (Q)SAR technologies to ENMs toxicity prediction, and summarizes the published nano-(Q)SAR studies and outlines the challenges ahead for nano-(Q)SAR modelling. It provides a critical review of (1) the present status of the availability of ENMs characterization/toxicity data, (2) the characterization of nanostructures that meets the need of (Q)SAR analysis, (3) the summary of published nano-(Q)SAR studies and their limitations, (4) the in silico tools for (Q)SAR screening of nanotoxicity and (5) the prospective directions for the development of nano-(Q)SAR models.

show abstract

Section: Nanomaterials Toxicitymentioning

confidence: 99%

(Q)SAR modelling of nanomaterial toxicity: A critical review

et al. 2015

View full text Add to dashboard Cite

show abstract

“…Generation of ROS appears to be a major mechanism of nanotoxicity 31 and we generated positive control samples by exposing cells to ultraviolet (UV)-A radiation, a ROS-generating agent that is a suitable mediator of oxidative stress (OS) and outside the absorbance range of cellular components. conditions which have previously generated an ROS-stimulated response in bacteria.…”

Section: Experimental and Control Treatmentsmentioning

confidence: 99%

Mid-infrared spectroscopic assessment of nanotoxicity in Gram-negative vs. Gram-positive bacteria

Heys

Riding

Strong

et al. 2014

Analyst

View full text Add to dashboard Cite

Vibrational spectroscopy provides a spectral fingerprint identifying the effects of carbonbased nanoparticles in bacterial cells. 3 ABSTRACTNanoparticles appear to induce toxic effects through a variety of mechanisms including generation of reactive oxygen species (ROS), physical contact with the cell membrane and indirect catalysis due to remnants from manufacture. The development and subsequent increasing usage of nanomaterials has highlighted a growing need to characterize and assess the toxicity of nanoparticles, particularly those that may have detrimental health effects such as carbon-based nanomaterials (CBNs). Due to interactions of nanoparticles with some reagents, many traditional toxicity tests are unsuitable for use with CBNs. Infrared (IR) spectroscopy is a non-destructive, high throughput technique, which is unhindered by such problems. We explored the application of IR spectroscopy to investigate the effects of CBNs on Gram-negative (Pseudomonas fluorescens) and Gram-positive (Mycobacterium vanbaalenii PYR-1) bacteria. Two types of IR spectroscopy were compared: attenuated total reflection Fourier-transform infrared (ATR-FTIR) and synchrotron radiation-based FTIR (SR-FTIR) spectroscopy. This showed that Gram-positive and Gram-negative bacteria exhibit differing alterations when exposed to CBNs. Gram-positive bacteria appear more resistant to these agents and this may be due to the protection afforded by their more sturdy cell wall. Markers of exposure also vary according to Gram status; Amide II was consistently altered in Gram-negative bacteria and carbohydrate altered in Gram-positive bacteria. ATR-FTIR and SR-FTIR spectroscopy could both be applied to extract biochemical alterations induced by each CBN that were consistent across the two bacterial species; these may represent potential biomarkers of nanoparticle-induced alterations. Vibrational spectroscopy approaches may provide a novel means of fingerprinting the effects of CBNs in target cells.

show abstract

“…Lead penetrating placenta and entering cells will lead to the formation of reactive oxygen species (ROS). ROS formed in trophoblast cells will cause mitochondrial damage, therefore it causes loose of cytochrome caught by apaf-1, then it will activate caspase-3 as the executor of apoptosis [10]. In this study TNF-毩 expression, spiral artery remodeling and apoptosis index in lead-exposed treatment group (Group 2 and 3) are higher than control group without treatment (Group 1).…”

Section: Discussionmentioning

confidence: 51%