Influence of Stress on Epithelial Cell Proliferation in the Gut Mucosa of Rats

Greant, P; Delvaux, Georges; Willems, G

doi:10.1159/000199657

Cited by 20 publications

(11 citation statements)

References 6 publications

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“…Mucosal resistance is related to, among other factors, mucosal blood flow, mucus and prostaglandin production, and rapid mucosal cell turnover. Inhibition of mucosal cell proliferation or excessive apoptosis results in the development of ulcers [52,53]. On the other hand, the increase in cell proliferation leads to reduction of mucosal damage and accelerates healing of mucosal ulcers [54–57].…”

Section: Discussionmentioning

confidence: 99%

Ghrelin accelerates the healing of cysteamine-induced duodenal ulcers in rats

et al. 2012

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SummaryBackgroundPrevious studies have shown that administration of ghrelin exhibits protective and therapeutic effects in the gut. The aim of the present investigation was to examine the influence of ghrelin administration on the course of cysteamine-induced duodenal ulcers, as well as effects on mucosal production of oxygen free radicals and duodenal antioxidant defense.Material/MethodsDuodenal ulcers were induced in male Wistar rats by cysteamine administered intragastrically at the dose of 200 mg/kg in 1 ml of saline, 3 times at 4-h intervals. Starting 24 h after the first dose of cysteamine, rats were treated intraperitoneally twice a day with saline or ghrelin given at the dose of 4, 8 or 16 nmol/kg/dose. Seven days after administration of the first dose of cysteamine, the study was terminated.ResultsInduction of ulcers by cysteamine was accompanied by a reduction in duodenal blood flow, mucosal DNA synthesis and mucosal activity of superoxide dismutase (SOD); whereas mucosal concentration of interleukin-1β and malonyldialdehyde (MDA – an index of lipid peroxidation) were increased. Treatment with ghrelin increased healing rate of duodenal ulcers and enhanced duodenal blood flow, mucosal DNA synthesis and mucosal activity of SOD, and reduced mucosal concentration of interleukin-1β and MDA.ConclusionsTreatment with ghrelin increases the healing rate of duodenal ulcers and this effect is related, at least in part, to improvement of duodenal mucosal blood flow, mucosal cell proliferation and antioxidant defense, as well as being related to reduction in mucosal oxidative stress and inflammatory response.

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Section: Discussionmentioning

confidence: 99%

Ghrelin accelerates the healing of cysteamine-induced duodenal ulcers in rats

et al. 2012

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“…In other experimental studies, variations in proliferation rate within intestinal regions have also been reported, e.g. in rats subjected to thermal stress (Greant et al, 1988) and in the colon of mice fed with a vitamin D-deficient diet (Sadava et al, 1996). Specific adaptive responses of each anatomical region and differences in the expression of vitamin D receptors within the gastrointestinal tract have been reported in goats, sheep (Liesegang et al, 2007;Riner et al, 2008) and rabbits (Duncan et al, 1984).…”

Section: ;mentioning

confidence: 79%

Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits

Zanuzzi

Nishida

Portiansky

et al. 2012

Research in Veterinary Science

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Vitamin D regulates mineral homeostases and enterocyte proliferation and differentiation. Hypervitaminosis D generates changes in cell proliferation, differentiation and apoptosis in several organs. We analysed morphometric parameters and proliferative and apoptotic indices in the intestinal epithelium of rabbits with hypervitaminosis D induced by the chronic treatment with the calcinogenic plant Solanum glaucophyllum. Rabbits were treated for 15 or 30 days. A group was treated for 15 days and led to possible recovery for 30 days. Another group was nutritionally restricted for 30 days. Morphological, morphometric, proliferative and apoptotic changes were found in the treated animals. Mild atrophy and reduced proliferation was found in the jejunum and ileum. Apoptosis increased in the crypts of the ileum and in the superficial epithelium and crypts of the rectum. Most of the alterations were partially recovered. The possible involvement in these changes of the hypervitaminosis D-like state induced by S. glaucophyllum is discussed.

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“…Although there is some evidence indicating that HRS does not have any influence on gastric cell renewal (58), other experiments have shown that HRS results in a decrease in the mitotic activity of the mucosal lining of the stomach (21,98,188). Consistent with this finding, a wide range of studies have demonstrated that the DNA synthesis and content in the gastric mucosa of stressed rats are decreased.…”

Section: Effects Of Stress On the Stomach: Gastric Ulcer Formationmentioning

confidence: 81%

“…In fact, a complete absence of villi in the duodenum of stressed rats has been documented (195,196). Another factor that could be implicated in the impairment of intestinal barrier function is the inhibition of cell renewal produced upon stress in the mucosa of duodenum, ileum and colon (58), where the content of DNA, RNA and proteins has been consistently described to be decreased under stress (170,195).…”

Section: Effects Of Stress On the Intestinementioning

confidence: 99%

Effect of psychogenic stress on gastrointestinal function

Medina

2000

J Physiol Biochem

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This review summarizes the studies published over the last twenty years on the effects of psychogenic stress on gastrointestinal function, using animal models. The effects of stress on gastric ulceration have received wide attention and the central and local mechanisms of mucosal damage have been, for the most part, clearly delineated. In comparison, relatively few studies have focused on the impact of stress on intestinal and colonic physiology, even though its influence on intestinal motility, mucosal permeability and inflammation has been established. More work is necessary in this field, especially considering the importance of irritable bowel syndrome in modern society.

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Influence of Stress on Epithelial Cell Proliferation in the Gut Mucosa of Rats

Cited by 20 publications

References 6 publications

Ghrelin accelerates the healing of cysteamine-induced duodenal ulcers in rats

Ghrelin accelerates the healing of cysteamine-induced duodenal ulcers in rats

Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits

Effect of psychogenic stress on gastrointestinal function

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