Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits

Zanuzzi, Carolina Natalia; Nishida, Fabián; Portiansky, Enrique Leo; Fontana, Paula Andrea; Gimeno, Eduardo Juan; Barbeito, Claudio Gustavo

doi:10.1016/j.rvsc.2011.07.018

Cited by 14 publications

(14 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The excess of vitamin D can be toxic to tissues by inducing the mineralization of soft tissues, R. Bras. Zootec., 47:e20170186, 2018 has negative effect on leg health, decreases body weight gain, and increases feed cost (Cruickshank and Sim, 1987;Zanuzzi et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Effects of 1,25-dihydroxycholecalciferol and reduced vitamin D3 level on broiler performance and bone quality

et al. 2018

View full text Add to dashboard Cite

This study was conducted to evaluate the effect of two levels of vitamin D 3 with or without 1,25dihydroxycholecalciferol (1,25(OH) 2 D 3) on live performance and bone quality of broiler chickens. For that, we used a completely randomized design in a 2 × 2 factorial arrangement, with eight replicates of 30 Cobb ® 500 male broiler chicks each (n = 960). The two levels of vitamin D 3 and the addition or not of 0.5 µg 1,25(OH) 2 D 3 /kg were considered as main factors. The vitamin D 3 levels were: 2500/2000 IU/kg and 1250/1000 IU/kg for the starter (1 to 21 days) and grower (22 to 40 days) phases, respectively, with the first representing the levels used in industry (100%) and the second, a reduction in 50% of those levels. The 1,25(OH) 2 D 3 source was Solanum glaucophyllum. On days 21 and 40, one broiler per replicate was killed and long bones were removed for analyses of mineral percentage, bone mineral density, biomechanical properties, and morphology. No significant differences were found related to vitamin D 3 levels and the addition or not of 1,25(OH) 2 D 3 for live performance, mineral percentage, strength, stiffness, and morphology. Toughness was lower when 1,25(OH) 2 D 3 was used at 21 days, but this effect was not observed at 40 days of age. Bone mineral density was greater when 100% of vitamin D 3 was used at 40 days of age. The reduction of up to 50% of vitamin D 3 levels is sufficient to ensure performance and bone development of broilers at 21 and 40 days of age. The inclusion of 0.5 µg 1,25(OH) 2 D 3 /kg in addition to diets with sufficient levels of vitamin D 3 shows no effect on the improvement of those parameters at the same ages.

show abstract

Section: Introductionmentioning

confidence: 99%

Effects of 1,25-dihydroxycholecalciferol and reduced vitamin D3 level on broiler performance and bone quality

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Isto porque estão localizadas em concentrações mais elevadas próximos a locais em que ocorrem maior diferenciação e proliferação celular no intestino, sugerindo sua atuação no desenvolvimento, integridade, homeostase e saúde intestinal (Klasing 2006, Riner et al 2008, Zanuzzi et al 2011. De acordo com McCarthy et al (1984), este mecanismo se torna mais evidente quando administrado vitamina D após um período de deficiência, fazendo com que sua ação aconteça rapidamente de forma a reparar os danos causados pela deficiência.…”

Section: Discussionunclassified

Utilização da vitamina D3 e seus metabólitos na alimentação de frangos de corte sobre parâmetros imunológicos e morfometria intestinal

et al. 2014

View full text Add to dashboard Cite

to the ileum (P<0.05). There were no differences (P>0.05) for weight of lymphoid organs, cutaneous basophil hypersensitivity reaction, macrophage activity assessment, measurement of nitric oxide and heterophil profile: lymphocyte. The different sources of vitamin D affect the intestine morphometrics on the villi length in the initial phase, but the effect was not observed in other phases. The immunological parameters were not affected by metabolites of vitamin D.

show abstract

“…Negative control sections were prepared by omitting primary antibody. Positive control sections for PCNA were samples of mammalian intestine (Zanuzzi et al, ) and for NKP were samples of chicken kidney (Pastor et al, ). To calculate the proliferation index in the four intestinal portions we counted at least 700 enterocytes per slide using a 100× objective.…”

Section: Methodsmentioning

confidence: 99%

Immunohistochemical and ultrastructural evidence of functional organization along the Corydoras paleatus intestine

Plaul

Pastor

Díaz

et al. 2016

Microscopy Res & Technique

View full text Add to dashboard Cite

The Neotropical catfish, Corydoras paleatus (Callichthyidae) is a facultative air-breathing teleost that makes use of the caudal portion of the intestine as an accessory air-breathing organ. This portion is highly modified, being well vascularized with capillaries between epithelial cells, which makes it well suited for gas exchange. Instead, the cranial portion is a digestion and absorption site, as it has a typical intestinal epithelium with columnar cells arranged in a single row, villi and less vascularized tunica mucosa. Therefore, the intestine was studied by light and electron microscopy to assess differences between the cranial, middle and caudal portions. To characterize the potential for cell proliferation of this organ, we used anti-proliferating cell nuclear antigen antibody and anti-Na(+) K(+) -ATPase monoclonal antibody to detect the presence of Na(+) /K(+) pump. In C. paleatus it was observed that cell dynamics showed a decreasing gradient of proliferation in cranio-caudal direction. Also, the intestine of this catfish is an important organ in ionoregulation: the basolateral Na(+) /K(+) pump may have an active role, transporting Na(+) out of the cell while helping to maintain the repose potential and to regulate cellular volume.

show abstract

Effects of Solanum glaucophyllum toxicity on cell proliferation and apoptosis in the small and large intestine of rabbits

Cited by 14 publications

References 46 publications

Effects of 1,25-dihydroxycholecalciferol and reduced vitamin D3 level on broiler performance and bone quality

Effects of 1,25-dihydroxycholecalciferol and reduced vitamin D3 level on broiler performance and bone quality

Utilização da vitamina D3 e seus metabólitos na alimentação de frangos de corte sobre parâmetros imunológicos e morfometria intestinal

Immunohistochemical and ultrastructural evidence of functional organization along the Corydoras paleatus intestine

Contact Info

Product

Resources

About