Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits

Abdel-Daim, Mohamed M.; Ahmed, Amira; Ijaz, Hira; Abushouk, Abdelrahman Ibrahim; Ahmed, Hussien; Negida, Ahmed; Aleya, Lotfi; Bungău, Simona

doi:10.1007/s11356-019-04249-4

Cited by 42 publications

(25 citation statements)

References 49 publications

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“…There are also animal and human studies showed that the MDA value does not change despite the increased oxidation (Kamendulis et al 1999;Ma'rifah et al 2019;McGrath et al 2001). A signi cant increase in BUN level in the AK-induced nephrotoxicity group when compared to the control group was demonstrated in the AK-induced nephrotoxicity model (Abdel-Daim et al 2019;Parlakpinar et al 2006). Similar to this nding, we have shown that the BUN level was higher in the AK-induced nephrotoxicity group when compared to the control group in this study.…”

Section: Discussionsupporting

confidence: 89%

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Carvacrol attenuates amikacin-induced nephrotoxicity in the rat

Dost

Gunata

Özhan

et al. 2021

Preprint

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Amikacin (AK) is frequently used in the treatment of gram-negative and some gram-positive infections. However, its use is limited due to nephrotoxicity due to the increase in reactive oxygen radicals. The aim of this study was to investigate the role of carvacrol (CAR) against AK-induced nephrotoxicity in rats. Thirty-two Sprague Dawley rats were randomly divided into four groups as control (Vehicle), AK (400 mg/kg), CAR + AK (80 mg/kg CAR + 400 mg/kg AK), and AK + CAR (400 mg/kg AK + 80 mg/kg CAR) groups. AK and CAR were administered via intramuscular and per-oral for 7 days, respectively. Blood and kidney tissue samples were taken at the end of the experiment. Renal function and histopathological changes were compared, and the relevant parameters of oxidative stress and inflammation were detected. Histopathological findings (necrotic changes and dilatation and inflammatory cell infiltration) significantly increased in the AK group compared to the control group. Also, the rats in the AK group lost weight significantly. It was found that CAR treatment before and after AK significantly improved nephrotoxicity histopathologically (p < 0.05). However, this improvement was not detected biochemically. These results show that CAR treatment before and after AK improves nephrotoxicity in the histopathological level.

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Section: Discussionsupporting

confidence: 89%

“…These mechanisms include decreased blood supply to the renal tissue, decreased glomerular ltration rate, and tubular cytotoxicity. The contraction of mesangial cells and the release of vasoconstrictor hormones such as angionthecin 2 may cause the decrease in the blood supply of the renal tissue (Abdel-Daim et al 2019;Krause et al 2016).…”

Section: Discussionmentioning

confidence: 99%

Carvacrol attenuates amikacin-induced nephrotoxicity in the rat

Dost

Gunata

Özhan

et al. 2021

Preprint

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“…Numerous experimental studies have also shown the nephrotoxicity of some of the antibiotics chosen in UTIs treatment, as well as the protective effects of vitamins (E, C) in combination with certain substances (ceftriaxone, allicin, etc.) [35][36][37].…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains

Haşegan¹,

Totan²,

Antonescu³

et al. 2019

Rev. Chim.

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Urinary tract infections (UTIs) are the most common bacterial pathologies in children, but they are difficult to spot. The diagnosis relies on urine culture in order to measure the prevalence of the infection, to identify the etiology and the sensitivity of the germs to different antibiotics. Escherichia coli (E. coli) strains are the most common uro-pathogen germs. The change in sensitivity to antibiotic of these uro-pathogen bacteria should be closely monitored because the physicians should be informed about the evolution of the antibiotic resistance of E coli, for a more effective treatment in their fight against diseases. The study aimed to determine the prevalence of UTIs and the evolution of antimicrobial sensitivity for E. coli. This retrospective study was performed over a period of 4 years, 2013-2016, and included all the patients admitted in the Children�s Hospital, aged 0-18 years, with the suspicion of UTIs; also, the standard culture techniques for urine samples, the modified Kirby-Bauer disk diffusion method for the antibiotic sensitivity testing, and the disk diffusion method to confirm the ESBL production by the clinical isolates of E. coli in urine were used. The statistical analysis was performed using the proportions of sensitive, resistant and intermediates. Descriptive statistics like the total, mean and percentage were performed using the Statistical Package for the Social Sciences (SPSS), version 15.0 and Microsoft Excel. From 15389 urine cultures processed in 4 years, 1530 were positive (9.9 %). Among these positive urine cultures, 1056 (69 %) were positive for E. coli. Testing the E. coli to a range of antibiotics, according to CLSI standard, a high resistance to Ampicillin (69-96%), Amoxicillin/Clavulanic acid (32-70%), Trimethoprim/Sulfamethoxazole (36-42%) was observed and low levels of resistance to Ceftazidime, Cefuroxime, Cefpodoxime, Gentamycin, Nalidixic acid. Among E. Coli strains, 9-9.6 % were ESBL positive. Despite the low number of positive urine cultures in a paediatric population, it is very important to perform the urine culture in order to correctly identify the etiology of UTIs, recommend the right antibiotic, and avoid the wrong use of the antibiotics in children.

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“…It is well known and demonstrated by clinical and experimental studies that exposure to chemical substances also represent a risk factor for toxicity [11][12][13], or future development of tumors [14][15][16], in different organs like bladder, kidney etc [17][18][19][20], so a long follow up of the patients with self-injection should be required. In most of the cases the patients who practice illicit self-injection of those substances are young and they present to the doctor due to the complications that can appear during the following period (Table1).…”

Section: Resultsmentioning

confidence: 99%

Complications after Self-injection of Chemical Substances into the Penis

Martha¹,

Scarneciu²,

Scarneciu³

et al. 2019

Rev. Chim.

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Illicit injection of different, exogenous substances into the penis for enlargement purposes is a practice that is still met in some of the Eastern countries of Europe. Our study conducted over a period of 3 years (2016-2019) at the Urology Clinic from Tirgu Mures,highlights the complications that can occurre after the injection of different chemical substances, such as liquid paraffin, vaseline, olive oil etc., into the penile subcutaneous tissue with the purpose of augmentation. We report 7 patients presenting several complications some of them severe such as: extensive fibrosis, ulceration, penile deformity, erectile dysfunctions, requiring different surgical procedures. The surgical technique was selected according to the extension of fibrosis or necrosis:excision of the necrotic, fibrotic tissue, scrotal skin flap reconstruction etc. In our study, we found 7 patients that accomplished the inclusion criteria. Five patients were diagnosed with penile fibrosis after self-injection of Kanamycin, and two of the patients had the same diagnosis after self-injection of Vaseline. In 2 patients, the postoperative outcome was complicated by wound dehiscence and necrosis, requiring other reconstructive surgeries, and in 5 patients postoperative recovery was a favorable one, without significant complications. In the management of complications of illicit injection of different, exogenous substances into the penis, penile tunneling with scrotal flap technique seems to offer good results due to the vascular flap, allowing faster wound healing and a superior aesthetic and functional result.

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Influence of Spirulina platensis and ascorbic acid on amikacin-induced nephrotoxicity in rabbits

Cited by 42 publications

References 49 publications

Carvacrol attenuates amikacin-induced nephrotoxicity in the rat

Carvacrol attenuates amikacin-induced nephrotoxicity in the rat

Prevalence of Urinary Tract Infections in Children and Changes in Sensitivity to Antibiotics of E. coli Strains

Complications after Self-injection of Chemical Substances into the Penis

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