Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models

Binnebösel, Marcel; Klink, Christian D.; Grommes, Jochen; Jansen, Marc; Neumann, Ulf; Junge, K.

doi:10.1007/s00423-010-0672-8

Cited by 9 publications

(8 citation statements)

References 34 publications

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“…In this study intestinal leakage and another any surgical complications or infections were not observed in all groups. Similar to other reports [ 27 , 28 ] peritoneal adhesions between the incision line and the omentum or other surrounding tissues along the intestinal suture line were seen in one animal in both control and PG groups and three cases in GP group.…”

Section: Discussionsupporting

confidence: 91%

“…The most common complications of gastrointestinal operations are anastomotic leakage [ 25 , 26 ] and postsurgical peritoneal adhesions [ 27 , 28 ]. High morbidity and mortality are most frequently resulted by anastomotic leakages.…”

Section: Discussionmentioning

confidence: 99%

“…High morbidity and mortality are most frequently resulted by anastomotic leakages. Peritoneal adhesions can cause especially the morbidity including intestinal obstruction, infertility and the chronic abdominopelvic pain and are associated with multiple surgical complications [ 28 ]. In this study intestinal leakage and another any surgical complications or infections were not observed in all groups.…”

Section: Discussionmentioning

confidence: 99%

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The effect of gabapentin and pregabalin on intestinal incision wound healing in rabbits

Korkmaz¹,

Sarıtaş²,

Sevımlı³

et al. 2015

Vet World

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Aim:To evaluate the macroscopic and histologic effects of pregabalin (PG) gabapentin (GB) on longitudinal intestinal wound healing in New Zealand rabbits.Materials and Methods:The animals were divided into three groups randomly; the control group (n=6), PG group (n=6) and GB group (n=6). All animals were premedicated with xylazine HCI, 5 mg/kg i.m. and general anaesthesia was performed by ketamine HCI 50 mg/kg i.m injection. A 4 cm incision in the caecum through median laparotomy was achieved under aseptic surgery. Intestinal wound was closed with double-sutured. All animals were received parenteral antibiotic treatment for 5 days. PG and GB groups were treated by PG (30 mg/kg, oral, daily) and GB (30 mg/kg, oral, daily) for 10 days respectively. Control group did not receive any treatment. The animals were euthanized on day 10 and the caecum was examined by laparotomy. Adhesion formation was observed, and tissue samples were taken from suture lines for histologic examination. Cellular infiltration (polymorphonuclear white blood cells and mononuclear cells), accumulation of connective tissue, vascularization and extent of necrosis were evaluated and scored separately for each of mucosal, submucosal, muscular and serosal layers of caecum.Results:Adhesions were more severe in the GB group compared to other groups. No statistically significant differences were detected among the three groups about the wound healing.Conclusion:It was suggested that the use of gabapentinoids had no significant effect on wound healing in patients undergoing gastrointestinal surgery and further studies with treatment periods longer than 10 days are needed.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The effect of gabapentin and pregabalin on intestinal incision wound healing in rabbits

Korkmaz¹,

Sarıtaş²,

Sevımlı³

et al. 2015

Vet World

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“…Currently, three major approaches are taken to prevent or reduce post-surgical adhesion: minimizing surgical trauma, anti-fibrotic drugs, and the use of barriers [15]. A variety of materials, such as barrier membranes [16], gels [17] and degradable biocompatible polymers [18], have been applied to reduce adhesion formation by maintaining separation between serosal surfaces [19]. However, these materials are not widely used, due to problems associated with clinical application as well as other limiting factors [20].…”

Section: Resultsmentioning

confidence: 99%

The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats

Chen

Cheng

et al. 2012

IJMS

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Abdominal adhesions, whether caused by peritoneal trauma, radiation, infection, or a congenital condition, are associated with a wide range of complications. These complications include chronic abdominal or pelvic pain, infertility, and adhesive small bowel obstruction. Such adhesions render re-operation difficult, with attendant risks of inadvertent enterostomy and increased operation time. The purpose of this study was to investigate the potential of hyperbaric oxygen (HBO) therapy in the prevention of abdominal adhesions in an experimental animal study. A laparotomy was performed on Wistar rats to induce the formation of adhesions on the cecum and the intra-abdominal area (1 × 2 cm). A superficial layer of the underlying muscle from the right abdominal wall was also shaved and prepared for aseptic surgery. The rats were divided into four groups according to the duration of HBO therapy; five additional groups were designated according to the conditions of HBO therapy. When the rats were evaluated according to adhesion area and grade, a statistically significant difference was observed between the control and HBO treatment groups (p < 0.005). Results from this study suggest that HBO treatment could reduce adhesion formation; and further suggest that HBO therapy may have therapeutic potential in the treatment of postoperative peritoneal adhesion.

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“…The main conspicuous function of the mesothelium is the production of a lubricant surface that facilitates relatively free movement of abdominal viscera within the abdominal cavity. Additionally, it plays essential roles in the transport of fluid, resolution of inflammation, tissue healing, fibrin deposits lysis, protection against infecting microorganisms, and prevents adhesion formation [12][13][14][15]. Intestinal serosal damage occurs after intra-abdominal trauma and separation of the adhered or infiltrating cancer for the wall of the intestine [14,16].…”

Section: Introductionmentioning

confidence: 99%

Effect of Peritoneum Graft on Intestinal Anastomosis Healing After Deserosalization in Dogs

Alawi

Alkattan

AL-Taee

2023

Egyptian Journal of Veterinary Sciences

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T HE trauma and damage of the intestinal serosa layer resulted in serious complications. To solute these problems, many substances were used to cover up the affected serosa. This study demonstrated the possibility of using an autogenous peritoneal layer as an implant to overcome the complications of serosal layer damage at the anastomotic area. The study was conducted on twenty-four healthy adult local breed dogs. The serosal layer of the jejunum was removed and then a complete circumferential cut was made in the intestinal wall. The dogs were randomly allocated into two equal groups (n=12 each). In the control group, end-to-end jejunum anastomosis was done by a simple interrupted suturing technique. In the peritoneal group, the area of the anastomosis was sutured as the first group and wrapped by the peritoneum. After 15 days of surgery, both gross and histopathological investigations were studied. Correspondingly, radiographical investigation and bursting pressure test were performed on the 7 th and 15 th postsurgery. By comparison with the control group, the application of autologous peritoneal graft revealed an efficacious and beneficial effect on the healing process of the intestinal anastomotic site. The healing process in the peritoneal graft group was characterized by rapid mucosal re-epithelization, enhanced collagen fiber formation, and organization, no leakage, reduced adhesions and stenosis, and increased bursting pressure.In conclusion, wrapping of intestinal anastomosis area with an autologous peritoneal layer after serosal damage is a beneficial and effectual technique without severe complications.

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Influence of small intestinal serosal defect closure on leakage rate and adhesion formation: a pilot study using rabbit models

Cited by 9 publications

References 34 publications

The effect of gabapentin and pregabalin on intestinal incision wound healing in rabbits

The effect of gabapentin and pregabalin on intestinal incision wound healing in rabbits

The Effect of Postoperative Hyperbaric Oxygen Treatment on Intra-Abdominal Adhesions in Rats

Effect of Peritoneum Graft on Intestinal Anastomosis Healing After Deserosalization in Dogs

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