Influence of sleep duration on cortical oxygenation in elderly individuals

Kato, Kazuko; Miyata, Seiko; Ando, Motoo; Matsuoka, Hiroo; Yasuma, Fumihiko; Iwamoto, Kunihiro; Kawano, Naoki; Banno, Masahiro; Ozaki, Norio; Noda, Akiko

doi:10.1111/pcn.12464

Cited by 7 publications

(8 citation statements)

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“…In addition, there is some evidence that several biopsychosocial factors (e.g., circadian rhythms [240][241][242], level of sleepiness [243], and level of arousal [244]) can influence cognitive performance. In particular, it was observed (i) that measures of the cortical hemodynamic response (e.g., obtained during a cognitive test) are associated with total sleep duration [245,246] and sleepiness [247,248] and (ii) that total sleep duration is associated with acute exercise-related changes in behavioral performance (e.g., executive function performance) [82]. Interestingly, the relationship between total sleep duration and acute exercise-related changes in executive function performance are mediated by the volume of the caudate nuclei [82].…”

Section: Resultsmentioning

confidence: 99%

The Contribution of Functional Magnetic Resonance Imaging to the Understanding of the Effects of Acute Physical Exercise on Cognition

et al. 2020

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The fact that a single bout of acute physical exercise has a positive impact on cognition is well-established in the literature, but the neural correlates that underlie these cognitive improvements are not well understood. Here, the use of neuroimaging techniques, such as functional magnetic resonance imaging (fMRI), offers great potential, which is just starting to be recognized. This review aims at providing an overview of those studies that used fMRI to investigate the effects of acute physical exercises on cerebral hemodynamics and cognition. To this end, a systematic literature survey was conducted by two independent reviewers across five electronic databases. The search returned 668 studies, of which 14 studies met the inclusion criteria and were analyzed in this systematic review. Although the findings of the reviewed studies suggest that acute physical exercise (e.g., cycling) leads to profound changes in functional brain activation, the small number of available studies and the great variability in the study protocols limits the conclusions that can be drawn with certainty. In order to overcome these limitations, new, more well-designed trials are needed that (i) use a more rigorous study design, (ii) apply more sophisticated filter methods in fMRI data analysis, (iii) describe the applied processing steps of fMRI data analysis in more detail, and (iv) provide a more precise exercise prescription.Brain Sci. 2020, 10, 175 2 of 31 improve cognitive domains, such as attention and/or cognitive control substantially, albeit only transiently [30][31][32][33]. However, the underlying neurobiological mechanisms of these effects are not yet fully understood. In this regard, the use of neuroimaging methods offers great potential for acquiring a deeper understanding of physical exercise-induced changes in the neural correlates of cognition, such as changes in functional brain activation [33][34][35]. The most common methods used to investigate effects on functional brain activation are functional near-infrared spectroscopy (fNIRS) [34] and electroencephalography (EEG) [36,37]; however, also functional magnetic resonance imaging (fMRI) has recently been applied in the context of acute physical exercise and cognition [38,39]. The strengths of fNIRS and EEG compared to fMRI are a higher temporal resolution, greater portability, and applicability in almost all cohorts (e.g., for individuals with metallic implants or claustrophobia) [34,40,41]. However, fNIRS and EEG have a limited spatial resolution and only allow for the evaluation of brain activation patterns in cortical areas [41][42][43]. In comparison to fNIRS and EEG, fMRI enables the assessment of brain activation changes in cortical and subcortical areas and offers a higher spatial resolution, which results in superior source localization [42][43][44]. Hence, fMRI is well suited to study the influence of acute physical exercise on subcortical structures, such as the hippocampus, which have a crucial role in cognitive processes (e.g., memory) [45][46][47][48][49...

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Section: Resultsmentioning

confidence: 99%

The Contribution of Functional Magnetic Resonance Imaging to the Understanding of the Effects of Acute Physical Exercise on Cognition

et al. 2020

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“…Previous studies have used a cross‐sectional approach to show that sleep duration is positively associated with greater regional cerebral oxygenation during cognitive functioning (Kato et al, 2017, 2018; Suda et al, 2009; Yeung et al, 2018). This has been demonstrated in young (Kato et al, 2018; Suda et al, 2009; Yeung et al, 2018) and older (Kato et al, 2017) adults for cognitive tasks that involve working memory, word fluency, and verbal fluency.…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have used a cross-sectional approach to show that sleep duration is positively associated with greater regional cerebral oxygenation during cognitive functioning (Kato et al, 2017(Kato et al, , 2018Suda et al, 2009;Yeung et al, 2018). This has been demonstrated in young (Kato et al, 2018;Suda et al, 2009;Yeung et al, 2018) and older (Kato et al, 2017) the weekend versus weekday (Zhang et al, 2020) along with crosssectional data showing greater regional cerebral oxygenation despite similar performance on a working memory task in adults that sleep >7 h as compared to adults that sleep ≤7 h (Yeung et al, 2018).…”

Section: Sleep Extension and Cerebral Oxygenationmentioning

confidence: 95%

“…Insight into the effect of extended sleep on cognitive function may be obtained by measuring prefrontal cerebral oxygenation using near-infrared spectroscopy (NIRS). Previous research has shown lower frontal cerebral oxygenation during executive functioning in adults that habitually sleep <7 h as compared to those that sleep >7 h/night (Kato et al, 2017). This effect may be due in part to impaired cerebral vasomotor reactivity (i.e., cerebrovascular reactivity) associated with poor sleep quality (Qureshi et al, 1999).…”

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Six nights of sleep extension increases regional cerebral oxygenation without modifying cognitive performance at rest or following acute aerobic exercise

Clark

Rivas

Gonzales

2022

Journal of Sleep Research

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Sleep is recognised as an important factor that can contribute to cognitive impairment. Large cohort studies find self-reported short (<7 h) and long (≥9 h) sleep durations are associated with poor cognitive performance (Kondo et al., 2021;Low et al., 2019) and predict cognitive decline in older adults (Suh et al., 2018). In contrast, experimental studies extending sleep duration have produced mixed results. Some studies report improved cognitive performance (Arnal

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“…3 Insomnia is known to increase the risks for various physical disorders such as hypertension, diabetes, obesity and dyslipidaemia. 2 Furthermore, insomnia increases the risk of developing depression, 4 industrial accidents, 5 traffic accidents, 6 7 decreased brain activity [8][9][10] and cognitive impairments. 8 11 Strengths and limitations of this study ► This is the first prospective trial for elucidating the relationship between sleep and the glymphatic system in humans.…”

Section: Introductionmentioning

confidence: 99%

FLUID study: study protocol for an open-label, single-centre pilot study to investigate the efFect of Lemborexant on sleep management in Japanese sUbjects aged 50 years and older with Insomnia Disorder

et al. 2021

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IntroductionBidirectional associations have been reported between sleep disturbance and both cognitive impairment, including Alzheimer’s disease and amyloid beta-peptide (Aβ) accumulation. These relationships can be explained by the glymphatic system, which acts as a garbage drainage system in the brain. As interstitial fluid dynamics are suggested to increase during sleep, clearance of Aβ can be influenced by sleep disturbance or deprivation. We hypothesised that using lemborexant, an orexin receptor antagonist, to improve sleep quality would also improve the function of the glymphatic system. We plan to examine the effect of lemborexant on sleep quality and the glymphatic system among patients with insomnia disorder.Methods and analysisThis pilot study is designed as an open-label, single-arm, single-centre trial. Thirty patients aged 50 years and over with insomnia will be recruited. The participants will take lemborexant (5 mg) at bedtime for 12 weeks and undergo a home-based sleep study at baseline and weeks 4 and 12, as well as MRI examinations to evaluate the glymphatic system at baseline and week 12. The primary outcome will be changes in objective sleep parameters as evaluated using a sleep monitoring system. The secondary outcomes will be changes in subjective sleep parameters. The relationships between changes in sleep parameters and the glymphatic system will be evaluated using diffusion tensor image analysis along the perivascular space, which is called the ALPS-index. Sleep parameters and the ALPS-index will be analysed using a paired t-test or Pearson’s correlation coefficient.Ethics and disseminationThe study protocol was approved by Nagoya University Certified Review Board. The findings from this research will be published in peer-reviewed journals and be presented at local, national and international conferences.Trial registration numberjRCTs041210024.

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Influence of sleep duration on cortical oxygenation in elderly individuals

Abstract: Sleep duration may be an important factor that influences cortical oxygenation in the elderly population.

Cited by 7 publications

References 42 publications

The Contribution of Functional Magnetic Resonance Imaging to the Understanding of the Effects of Acute Physical Exercise on Cognition

The Contribution of Functional Magnetic Resonance Imaging to the Understanding of the Effects of Acute Physical Exercise on Cognition

Six nights of sleep extension increases regional cerebral oxygenation without modifying cognitive performance at rest or following acute aerobic exercise

FLUID study: study protocol for an open-label, single-centre pilot study to investigate the efFect of Lemborexant on sleep management in Japanese sUbjects aged 50 years and older with Insomnia Disorder

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