Influence of sinomenine upon mesenchymal stem cells in osteoclastogenesis

Zhou, Biao; Lu, Xiaoqing; Tang, Zhi; Liu, Dan; Zhou, Youliang; Zeng, Peng; Xiong, Hui

doi:10.1016/j.biopha.2017.03.084

Cited by 25 publications

(19 citation statements)

References 33 publications

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“…Sinomenine (Sino, C 19 H 23 NO 4 , M: 329.38), a kind of isoquinoline, is leached from the roots and stems of stems of Sinomenium actum Rehd.et wils. [13]. The proverbially pathological properties of Sino, such as anti-inflammatory and anti-tumor have been testified in the disparate ailments [14,15].…”

Section: Introductionmentioning

confidence: 99%

Sinomenine restrains breast cancer cells proliferation, migration and invasion via modulation of miR-29/PDCD-4 axis

Gao

Liang

Ma³

2019

Artificial Cells, Nanomedicine, and Biotechnology

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Sinomenine (Sino) is diffusely applied in heal rheumatoid arthritis and neuralgia. Howbeit, the activities of Sino in breast cancer cells remain confused. The research attempted to probe the anti-tumor function of Sino in breast cancer cells and divulge the feasible molecular mechanism. Sion at the 1-16 lM concentrations was exploited for the exposure of MDA-MB-231 or MCF7 cells, and cell growth, migration, invasion, cell cycle-relevant and apoptosis-correlative factors were estimated. Micro RNA (miR)-29 expression was evaluated via enforcing qRT-PCR, and the actions of miR-29 in MDA-MB-231 cells growth, migration and invasion were appraised after the overexpressed or suppressed vectors transfection. The functions of PDCD-4 in JNK and MEK/ERK pathways were estimated by employing western blot. We found that, Sino exposure impeded cell proliferation, provoked cell apoptosis and barricaded cell migration and invasion in MDA-MB-231 and MCF7 cells. Enhancement of miR-29 was observed in Sino-managed cells, and miR-29 overexpression further potentiated the activities of Sino in MDA-MB-231 cells. Additionally, Sino remarkably enhanced PCDC-4 expression via adjusting miR-29 in MDA-MB-231 cells. Beyond that, overexpressed PCDC-4 obstructed JNK and MEK/ERK pathways in MDA-MB-231 cells. Taken together, the explorations unveiled that Sino restrained MDA-MB-231 cells proliferation, migration, invasion, and provoked apoptosis through modulation of miR-29/PDCD-4 axis. HIGHLIGHT 1. Sino inhibits MDA-MB-231 and MCF7 cells proliferation and provokes apoptosis; 2. Sino restrains MDA-MB-231 and MCF7 cells migration and invasion; 3. Sino ascends miR-29 expression in MDA-MB-231 and MCF7 cells; 4. Sino adjusts cell growth, migration and invasion via modulating miR-29; 5. Sino up-regulates PDCD-4 expression through mediating miR-29; 6. PDCD-4 obstructs JNK and MEK/ERK pathways in MDA-MB-231 cells. ARTICLE HISTORY

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Section: Introductionmentioning

confidence: 99%

Sinomenine restrains breast cancer cells proliferation, migration and invasion via modulation of miR-29/PDCD-4 axis

Gao

Liang

Ma³

2019

Artificial Cells, Nanomedicine, and Biotechnology

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“…Osteoclast is a type of bone cell breaking down bone tissue, and collagen degradation mediated by which is also involved in the pathophysiology of OA [57]. Icariin [92] and sinomenine [93] suppress osteoclastogenesis through osteoprotegerin-NF-κB system. Halofuginone suppresses Th17-induced osteoclastogenesis via inhibition of TGF-β signaling [82].…”

Section: The Effects Of Bioactive Components On Subchondral Bone In Oamentioning

confidence: 99%

Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine

Zhang

2020

Chin Med

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Osteoarthritis (OA) is a common chronic articular degenerative disease, and characterized by articular cartilage degradation, synovial inflammation/immunity, and subchondral bone lesion, etc. The disease affects 2-6% of the population around the world, and its prevalence rises with age and exceeds 40% in people over 70. Recently, increasing interest has been devoted to the treatment or prevention of OA by herbal medicines. In this paper, the herbal compounds with anti-OA activities were reviewed, and the cheminformatics tools were used to predict their drug-likeness properties and pharmacokinetic parameters. A total of 43 herbal compounds were analyzed, which mainly target the damaged joints (e.g. cartilage, subchondral bone, and synovium, etc.) and circulatory system to improve the pathogenesis of OA. Through cheminformatics analysis, over half of these compounds have good drug-likeness properties, and the pharmacokinetic behavior of these components still needs to be further optimized, which is conducive to the enhancement in their drug-likeness properties. Most of the compounds can be an alternative and valuable source for anti-OA drug discovery, which may be worthy of further investigation and development.

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“… 87 Meanwhile, pro-inflammatory cytokines such as TNF-α and IL-6 can induce the expression of RANKL mesenchyme stem cells (MSCs) and promote the formation of osteoclasts. 88 MSCs can secrete a large amount of the soluble protein OPG, which can inhibit the gene expression of the nuclear factors of activated T cells, cytoplasmic 1 (NFATc1) and creatine kinase (CK), 89 thus competitively inhibiting the RANKL locus, so that OPG can indirectly inhibit the formation and activation of osteoclasts. 90 On the other hand, MSCs can secrete soluble molecules, such as PGE2, to participate in immunosuppression.…”

Section: The Potential Mechanisms Of Tcm To Antagonize Ramentioning

confidence: 99%

Applications and potential mechanisms of herbal medicines for rheumatoid arthritis treatment: a systematic review

Zhang

Jin

et al. 2019

RSC Adv.

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Influence of sinomenine upon mesenchymal stem cells in osteoclastogenesis

Cited by 25 publications

References 33 publications

Sinomenine restrains breast cancer cells proliferation, migration and invasion via modulation of miR-29/PDCD-4 axis

Sinomenine restrains breast cancer cells proliferation, migration and invasion via modulation of miR-29/PDCD-4 axis

Recent advance in treatment of osteoarthritis by bioactive components from herbal medicine

Applications and potential mechanisms of herbal medicines for rheumatoid arthritis treatment: a systematic review

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