Influence of serum estradiol on serum uric acid level in pre and postmenopausal women.

Abstract

ABSTRACT… Background: Hyperuricemia develops when serum uric acid level exceeds the normal value. Estrogen may influence the level of serum uric acid. Postmenopausal females have a remarkable reduction in its level, so serum estradiol is studied in relation to serum uric acid levels in pre and post-menopausal women. Objective: To find out the relationship of serum Estradiol with serum uric acid level in premenopausal and postmenopausal women in local population. Study Design: Case control study. Setting: This study was conducted in Lady Aitchison Hospital Lahore. Period: March 2017-August 2017. Material and Methods: 134 females were enrolled in total and were grouped in to two. Group A comprised of premenopausal and Group B included postmenopausal females. After complete history and general physical examination, 5 ml venous blood sample under aseptic measures was taken. Serum uric acid was measured by enzymatic and serum estradiol by Enzyme-linked immunosorbent assay method. Results: The mean age of pre and postmenopausal women was 32 and 57 ± 7 years, with significantly lower in premenopause. The mean serum E2 was 91.86 ± 26.71 mg/dL in premenopause and 22.04 ± 9.28 mg/dL in postmenopause, with significantly lower mean in postmenopause. Mean serum uric acid was statistically higher in postmenopause that was 6.04 ± 0.58 mg/dL, when compared to premenopause that was 4.22 ± 0.90 mg/dL. Conclusion: Serum uric acid levels increased due to decreased serum estradiol in postmenopausal women as compared to premenopausal women. Article Citation: Naseem R, Al-Fareed Zafar SM, Jawed S, Mukhtar S, Ijaz F, Aftab RK. Influence of serum estradiol on serum uric acid level in pre and postmenopausal women. Professional Med J 2019; 26(9):1587-1591.

An Association of Vitamin D Insufficiency with Elevated Serum Uric Acid Levels Among Postmenopausal Women

“…13 Raised serum uric acid (SUA) in postmenopausal women is linked to the lack of estrogen which is believed to be involved in the excretion of uric acid. 14 Excess uric acid has been related to the risk of hypertension, atherosclerosis and cardiovascular conditions. 15 Relationship of raised SUA level with vitamin D insufficiency is a significant metabolic disorder that is associated with cardiovascular diseases.…”