Influence of Selenium Nanoparticles on The Effects of Poisoning with Aflatoxins

Hassan, Atef A.; Mansour, Mogda K.; Sayed-ElAhl, Rasha M.H.; El-Din, Hanan A. Tag; Awad, Mohamed E.A.; Younis, Eman M.

doi:10.17582/journal.aavs/2020/8.s2.64.73

Cited by 6 publications

(14 citation statements)

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“…Nanoemulsions exhibit significantly high antifungal, bactericidal and virucidal activities. It may be attributed to greater adherence of the oil droplets on the surface of the microbial cells which facilitates the entrance of drugs to the cell [ 5 , 17 , 35 ].…”

Section: Nanoantifungals: Diversity and Relevance For Applications In Veterinary Medicinementioning

confidence: 99%

“…González-Jartín et al [ 109 ] observed that nanocomposites of carbon, bentonite, and aluminum oxide eliminated up to 87% of the mycotoxins with an adsorption efficiency of 450 µg/g. Chitosan-stabilized selenium nanoparticles have a significant ability to improve the toxic effects of aflatoxicosis in rats [ 35 , 110 ]. Further, the SeNPs exhibited important inhibitory effects on A. parasiticus, A. ochraceus, and Aspergillus nidulans growth at concentrations varying from 0.1–0.5 mg/L and ameliorate the dysfunction and hepatic apoptosis induced by AFB1 [ 30 ].…”

Section: Applications Of Nanoantifungals In Veterinary Medicinementioning

confidence: 99%

“…Nanomaterial possess a range of activities to inhibit the growth and multiplication of fungal-pathogens resulting in cell damage and loss of functions [ 3 , 5 , 35 , 38 ]. Nanomaterials exhibit a large surface area compared to the corresponding bulk materials [ 147 ].…”

Section: Nanoantifungals: Can These Be the Future Innovations In Veterinary Biomedicine?mentioning

confidence: 99%

“…Chronic exposure of buffalo sperm to ZnNPs and TiONPs (100 μg/mL) caused several abnormalities resulting in suppression of viability and diminished fertility [ 143 ], while, sperm exposure to 100–500 μg/mL of Zn NPs caused their damage and rapid death [ 153 ]. Hence, the estimation of safe doses of the used nanomaterial should be investigated in laboratory animals before application to field animals [ 35 , 72 , 94 ].…”

Section: Nanoantifungals: Can These Be the Future Innovations In Veterinary Biomedicine?mentioning

confidence: 99%

“…Furthermore, upon ingestion of nanomaterials by humans and animals they enter the alimentary tract, reach the circulatory system and are carried over via the liver and spleen [ 35 , 154 , 155 ], whereas, inhalation and skin exposure to nanomaterials allows for their penetration through the skin tissues and nerve cells [ 152 , 155 ]. Inhalation of TiO 2 NPs was identified to have an effect in the development of lung cancer [ 154 ].…”

Section: Nanoantifungals: Can These Be the Future Innovations In Veterinary Biomedicine?mentioning

confidence: 99%

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Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects

Alghuthaymi

Hassan

Kalia

et al. 2021

JoF

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The global recognition for the potential of nanoproducts and processes in human biomedicine has given impetus for the development of novel strategies for rapid, reliable, and proficient diagnosis, prevention, and control of animal diseases. Nanomaterials exhibit significant antifungal and antimycotoxin activities against mycosis and mycotoxicosis disorders in animals, as evidenced through reports published over the recent decade and more. These nanoantifungals can be potentially utilized for the development of a variety of products of pharmaceutical and biomedical significance including the nano-scale vaccines, adjuvants, anticancer and gene therapy systems, farm disinfectants, animal husbandry, and nutritional products. This review will provide details on the therapeutic and preventative aspects of nanoantifungals against diverse fungal and mycotoxin-related diseases in animals. The predominant mechanisms of action of these nanoantifungals and their potential as antifungal and cytotoxicity-causing agents will also be illustrated. Also, the other theragnostic applications of nanoantifungals in veterinary medicine will be identified.

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Section: Nanoantifungals: Diversity and Relevance For Applications In Veterinary Medicinementioning

confidence: 99%

Section: Applications Of Nanoantifungals In Veterinary Medicinementioning

confidence: 99%

Section: Nanoantifungals: Can These Be the Future Innovations In Veterinary Biomedicine?mentioning

confidence: 99%

Section: Nanoantifungals: Can These Be the Future Innovations In Veterinary Biomedicine?mentioning

confidence: 99%

Section: Nanoantifungals: Can These Be the Future Innovations In Veterinary Biomedicine?mentioning

confidence: 99%

See 3 more Smart Citations

Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects

Alghuthaymi

Hassan

Kalia

et al. 2021

JoF

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Remediation of emerging environmental pollutants: A review based on advances in the uses of eco-friendly biofabricated nanomaterials

Bhavya

Belorkar²,

Mythili³

et al. 2021

Chemosphere

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Ameliorative effects of camel milk and silymarin upon aflatoxin B1 induced hepatic injury in rats

Hassaneen,

Hemeda,

El Nahas

et al. 2023

Sci Rep

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Aflatoxin B1 (AFB1) poses a major risk to both human and animal health because it contaminates food, feed, and grains. These dangerous effects can be mitigated using natural components. The purpose of this study was to examine the ameliorative effects of camel milk and silymarin supplementation upon aflatoxin B1 induced hepatic injury in rats. This improvement was assessed by measuring leukocytic and deferential counts, serum biochemical parameters, and gene expression of Tumor Necrosis Factor (TNF-α), antioxidant gene (NAD(P)H quinone oxidoreductase 1 (NQO1)), and base excision repair genes (APE1 and OGG1) in the liver tissue, in addition to liver histopathology. Sixty mature males Wister white rats were used to perform the present study; the rats were distributed in six groups (ten rats/group). The control group (without any treatment) received saline by gavage. The camel milk group received 1 ml of camel milk/kg body weight. The silymarin group received 1 ml of silymarin suspension solution at a dose of 20 mg of silymarin/kg of b.wt. The aflatoxin group received an aflatoxin-contaminated diet at a dose of 1.4 mg of aflatoxin /kg of diet and received saline. The camel milk + aflatoxin group received the same previous oral doses of camel milk and an aflatoxin-contaminated diet at the same time. The silymarin + aflatoxin group received the same previous doses of silymarin orally and an aflatoxin-contaminated diet at the same time. The obtained data indicated the deleterious effect of aflatoxin B1 on the leukocytic count, activity of AST and ALT, serum proteins, ferritin, alpha-fetoprotein, carcinoembryonic antigen, liver pathology, and the expression of the studied genes. However, these deleterious effects were mitigated by camel milk and silymarin supplementation. Thus, we could conclude that the ingestion of camel milk and silymarin mitigated the negative effects of AFB1 on the hematology, activity of AST and ALT, serum proteins, ferritin, alpha-fetoprotein, carcinoembryonic antigen, liver pathology, and gene expression in the rat model.

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Influence of Selenium Nanoparticles on The Effects of Poisoning with Aflatoxins

Cited by 6 publications

References 0 publications

Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects

Antifungal Nano-Therapy in Veterinary Medicine: Current Status and Future Prospects

Remediation of emerging environmental pollutants: A review based on advances in the uses of eco-friendly biofabricated nanomaterials

Ameliorative effects of camel milk and silymarin upon aflatoxin B1 induced hepatic injury in rats

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