Influence of Selection for Increased Body Weight on the Incidence of Leiomyomas and Leiomyosarcomas in Japanese Quail

Foster, Douglas N.; Nestor, Karl E.; Ym, Saif; Bacon, Wayne L.; Moorhead, P. D.

doi:10.3382/ps.0681447

Cited by 19 publications

(8 citation statements)

References 20 publications

(18 reference statements)

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“…Myomas respond to the gonadal steroids estrogen and progesterone, and their epidemiology parallels the ontogeny and life-cycle changes in reproductive hormones. Smooth muscle tumors are also among the most common neoplasm in the avian species with prevalence varying up to 60% (3)(4)(5)(6)(7)(8)(9)(10)(11). Foster et al (10) reported that frequency of neoplasm ranged from 38.7% to 80% particularly in the quails.…”

Section: Introductionmentioning

confidence: 97%

Lycopene Supplementation Prevents the Development of Spontaneous Smooth Muscle Tumors of the Oviduct in Japanese Quail

Şahin¹,

Ozercan²,

Onderci³

et al. 2004

Nutrition and Cancer

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Leiomyomas (fibroids) are benign tumors of the uterus affecting millions of women. Spontaneous leiomyomas of the oviduct are common tumors of the Japanese quail (Coturnix coturnix japonica), which makes it a good animal model for screening potential agents for testing in the prevention and treatment of human myoma uteri. Because dietary intake of lycopene has been associated with a reduced risk of a variety of human cancers, we investigated the effects of lycopene supplementation on the development of leiomyomas in the oviduct of Japanese quail. We also measured serum levels of oxidative stress markers [malondialdehyde (MDA) and homocysteine], lycopene, vitamins C, E, and A, and tissue biomarkers Bcl-2 and Bax expression. One hundred twenty quails (6 mo old) were assigned to 3 treatment groups consisting of 4 replicates of 10 birds in each group. Birds were fed either a basal diet (group C) or the basal diet supplemented with 100 mg (group L1) or 200 mg (group L2) of lycopene per kilogram of diet. The animals were sacrificed after 285 days and the tumors were identified. Lycopene supplementation decreased the number of leiomyomas compared with control subjects (P=0.056). The tumors in lycopene-fed birds were smaller than those found in control birds (P=0.01). There were no significant differences in the expression of tissue Bcl-2 and Bax among the study groups. Serum vitamins C, E, and A increased (P=0.01), whereas MDA and homocysteine concentrations decreased (P=0.01) with lycopene supplementation. No measurable lycopene could be detected in the serum of control birds, whereas a dose-dependent increase was observed in the serum of lycopene-supplemented birds. The results indicate that dietary supplementation with lycopene reduces the incidence and size of spontaneously occurring leiomyoma of the oviduct in the Japanese quail. Clinical trials should be conducted to investigate the efficacy of lycopene supplementation in the prevention and treatment of uterine leiomyoma in humans.

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Section: Introductionmentioning

confidence: 97%

Lycopene Supplementation Prevents the Development of Spontaneous Smooth Muscle Tumors of the Oviduct in Japanese Quail

Şahin¹,

Ozercan²,

Onderci³

et al. 2004

Nutrition and Cancer

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show abstract

“…7,8 The predilection site for avian smooth muscle tumors is the genital system, especially the mesosalpinx of females and the epididymis and ductus deferens of males. 9 Leiomyosarcomas have been documented in pigeons (Columba livia), 10,11 budgerigars (Melopsittacus undulatus), 12,13 broiler chickens, 8,14 commercial layer flocks, 15 Japanese quail (Coturnix japonica), 16,17 golden pheasants (Chrysolophus pictus), 18 a blue-fronted Amazon parrot (Amazona aestiva), 19 and a sarus crane (Grus antigone). 20 In some reports, the metastatic and nonmetastatic neoplasms were associated with the avian leukosis/ sarcoma complex.…”

Section: Discussionmentioning

confidence: 99%

Metastatic Leiomyosarcoma Originating in the Thigh Skeletal Muscle of a Larry Breed Hen

Kheirandish¹,

Azizi²,

Salehi³

et al. 2016

Journal of Avian Medicine and Surgery

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“…Leiomyomas of the reproductive tract occur in several species of domestic animals, including the potbellied pig [49], the quail [50], and the German Shepherd dog [51], and nondomestic animals such as the otter [52], seal [53], cheetah [54], white rhinoceros [55], elephant [56], and crab-eating macaque [57]. Although the high incidence of uterine fibroids and their associated clinical problems are significantly important among reproductive aged women, the molecular basis for the initial myocyte transformation and growth of these tumors remains unknown.…”

Section: Discussionmentioning

confidence: 99%

Validation of the Aging Hen (Gallus gallus domesticus) as an Animal Model for Uterine Leiomyomas1

Machado

Bahr

Hales

et al. 2012

Biology of Reproduction

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Uterine leiomyomas, or fibroids, are the most frequent gynecological tumors in premenopausal women with as many as 65% of women becoming clinically symptomatic. Uterine fibroids are benign myometrial tumors that produce large quantities of extracellular matrix proteins. Despite its high morbidity, the molecular basis underlying the development of uterine leiomyomas is not well understood. Domestic hens of Gallus gallus domesticus develop oviductal leiomyomas similar to those found in humans. We investigated the natural history of chicken leiomyomas, in vivo expression of protein biomarkers, and in vitro expression of ovarian steroid receptors. Based on the analysis of 263 hens, tumor prevalence, tumor number per hen, and tumor size increased as the hens aged. Immunohistochemistry for alpha-smooth muscle actin (SMA) and desmin confirmed the smooth muscle phenotype of the chicken leiomyomas. Intense collagen expression was detected in these oviductal leiomyomas by Mason's trichrome, and the tumors also showed increased expression of TGFB3 and collagen type I mRNAs. Consistent with human leiomyomas, chicken fibroids displayed increased BCL2 and estrogen (E) and progesterone (P) receptor expression. Chicken leiomyomas were dissociated for in vitro culture. Cells from explants were positive for SMA, desmin, and E and P receptors until the fourth passage. These cells also displayed a response similar to human cells when challenged with halofuginone, an antifibrotic agent. Our findings indicate that the chicken is an excellent complementary model for studies involving the pathophysiology of human uterine leiomyomas.

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Influence of Selection for Increased Body Weight on the Incidence of Leiomyomas and Leiomyosarcomas in Japanese Quail

Cited by 19 publications

References 20 publications

Lycopene Supplementation Prevents the Development of Spontaneous Smooth Muscle Tumors of the Oviduct in Japanese Quail

Lycopene Supplementation Prevents the Development of Spontaneous Smooth Muscle Tumors of the Oviduct in Japanese Quail

Metastatic Leiomyosarcoma Originating in the Thigh Skeletal Muscle of a Larry Breed Hen

Validation of the Aging Hen (Gallus gallus domesticus) as an Animal Model for Uterine Leiomyomas1

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