Influence of Routine Administration of Folic Acid and Iron during Pregnancy

Blot, I; Papiernik, E; Kaltwasser, J. P.; Werner, Eric; Tchernia, Gil

doi:10.1159/000299659

Cited by 69 publications

(29 citation statements)

References 10 publications

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“…It was observed that higher maternal folate concentrations during late pregnancy had no benefit for reducing the risk of SGA in a multiethnic Asian population [26]. If there is an effect of FA supplementation during pregnancy on SGA, it may possibly only be observed in the face of more generalized maternal folate depletion [27]. …”

Section: Discussionmentioning

confidence: 99%

Maternal Continuing Folic Acid Supplementation after the First Trimester of Pregnancy Increased the Risk of Large-for-Gestational-Age Birth: A Population-Based Birth Cohort Study

Wang

Zhu

et al. 2016

Nutrients

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Supplementation with folic acid (FA) was proven to prevent neural tube defects (NTDs) and was recommended worldwide before and during early pregnancy. However, much less is known regarding the role of FA after the 12th gestational week (GW). This study aimed to investigate the related effects of continued FA supplementation after the first trimester of pregnancy on fetal growth. The study subjects came from the Ma’anshan-Anhui Birth Cohort Study (MABC) that recruited 3474 pregnant women from the city of Ma’anshan in Anhui Province in China during the period of May 2013 to September 2014. The information on use of vitamin and mineral supplements was recorded in different periods (the first/second/third trimester of pregnancy). Small-for-gestational-age (SGA) births were live-born infants that were <10th percentile of birth weight, and large-for-gestational-age (LGA) births were live-born infants that were ≥90th percentile of birth weight according to nomograms based on gender and gestational age from the latest standards. We used multivariable logistic regression to evaluate the effects of FA supplement consumption in the second/third trimester of pregnancy on the risk of LGA and SGA. In addition, propensity score analysis was also performed to examine the effects. In this prospective birth cohort study conducted in Chinese women who had taken FA in the first trimester of pregnancy, we found that continued FA supplementation with 400 micrograms/day in the second and third trimesters of pregnancy significantly increased the risk of LGA (RR = 1.98 (1.29, 3.04)). This relation was strong or monotonic after adjusting for maternal age, newborn’s gender, maternal pre-pregnancy BMI, maternal education level, smoking, alcohol consumption and calcium supplementation. We did not observe that continuing FA supplementation after the first trimester of pregnancy remarkably decreased the risk of SGA. The propensity score analysis showed similar results. To confirm these findings, additional investigations or trials with a large sample and the tracking of folate status throughout pregnancy are recommended.

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Section: Discussionmentioning

confidence: 99%

Maternal Continuing Folic Acid Supplementation after the First Trimester of Pregnancy Increased the Risk of Large-for-Gestational-Age Birth: A Population-Based Birth Cohort Study

Wang

Zhu

et al. 2016

Nutrients

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“…Blotet al [14] report that more than one third of the women after 6 months of pregnancy or at delivery exhibit plasma folate levels below normal. However, Hall et al [15], in a study of a complete antenatal population, suggest that the fall in serum folate level that occurs in normal pregnancy is due mainly to plasma volume expansion and should be regarded as physiologic.…”

Section: Discussionmentioning

confidence: 99%

Levels of Iron, Vitamin B<sub>12</sub>, Folic Acid and Their Binding Proteins during Pregnancy

Zamorano¹,

Arnalich²,

Casas

et al. 1985

Acta Haematol

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One hundred pregnant women, not anemic and not receiving iron or vitamin supplements, were chosen at random among the three trimesters of pregnancy to determine the incidence of unexpected iron, plasma folate and/or cobalamin deficiency, and the significance of fluctuating levels of their respective binding proteins. Pregnant females had a nonsignificant fall in serum iron and a fourfold decline in serum ferritin in the 3rd trimester compared with 1st trimester values. There was a steady decrease in plasma cobalamin and cobalophilin levels in every trimester but no difference in transcobalamin II values. Unsaturated cobalamin (UBBC) and unsaturated transcobalamin binding capacity (UTCBC) were lower in the 1st trimester fully recovering afterwards. Plasma folate levels were not lower, although there was a steady reduction in total and unsaturated folate binding capacity throughout pregnancy

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“…5 It has been noted that about 8% of pregnant women need permanent drug treatment due to various chronic disease and pregnancy induced complications. 6 But unfortunately due to easy availability of drugs coupled with inadequate health services, increased proportions of drugs are used as selfmedications, as compared to the prescribed drugs which lead to adverse drug reactions and drug interactions during pregnancy.…”

Section: Introductionmentioning

confidence: 99%

Drug utilization pattern in pregnancy at a tertiary care hospital in Puducherry: a cross sectional observational study

Selvaraj

Sekar

Gandhi

et al. 2018

Int J Basic Clin Pharmacol

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Background: Drug utilization pattern in pregnancy population provide insights regarding drug profile and interventional measures and also minimizes the inherent risk occurring due to unethical prescription.Methods: It was a prospective cross sectional study where prescription slips were collected. Further drugs were categorized according to the classification defined by US Food and drug Administration for pregnancy. Using Pre validated questionnaire the pregnant women were interviewed and parameters regarding knowledge about antenatal visit and contraception, self-medication practices were noted.Results: Among the total 365 participants, 81.4% had finish their high schooling and were in reproductive age group of 22-25. Study revealed predominant usage category- A drugs in I (95.5%), II (97.8%), III (96.4%) trimester. None of them received Category D or X drugs. Almost 100% and 98.6% in III and II trimester respectively received iron. Other drugs prescribed were calcium, anti-emetics, anti-ulcer, NSAIDS and antimicrobial. The awareness about Intra Uterine Contraceptive Devices and Oral Contraceptive Pills were 48.2% and 31.5% respectively. Unfortunately only 4.9% felt that drug use could be dangerous to foetus. 58.9% were aware about antenatal examination during pregnancy.Conclusions: Evaluation of drug utilization pattern periodically will minimize incidence of risk to foetus and mother during pregnancy.

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Influence of Routine Administration of Folic Acid and Iron during Pregnancy

Cited by 69 publications

References 10 publications

Maternal Continuing Folic Acid Supplementation after the First Trimester of Pregnancy Increased the Risk of Large-for-Gestational-Age Birth: A Population-Based Birth Cohort Study

Maternal Continuing Folic Acid Supplementation after the First Trimester of Pregnancy Increased the Risk of Large-for-Gestational-Age Birth: A Population-Based Birth Cohort Study

Levels of Iron, Vitamin B<sub>12</sub>, Folic Acid and Their Binding Proteins during Pregnancy

Drug utilization pattern in pregnancy at a tertiary care hospital in Puducherry: a cross sectional observational study

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