Influence of Rosemarinus officinalis Extract on Radiation-Induced Intestinal Injury in Mice

Jindal, Archana; Agrawal, Annapurna; Goyal, Pradeep

doi:10.1615/jenvironpatholtoxicoloncol.v29.i3.10

Cited by 6 publications

(3 citation statements)

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“…Some of these studies illustrate that rosemary and its components are protective against environmental toxins in experimental animal models of hepatotoxicity [62], bronchial cells [63] and may assist in inducing phase II detoxification enzymes. Rosemary extract was also found to be radioprotective against gamma radiation induced disorders in mice [64,65].…”

Section: Clinical Safety and Efficacymentioning

confidence: 99%

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

2015

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Section: Clinical Safety and Efficacymentioning

confidence: 99%

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

2015

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“…The radioprotective properties were revealed for some botanical or herbal plants, such as Tinospora cardifolia, Panax ginseng, Rosemarinus officinalis, Aloe vera, Embilica officinalis, Alstonia scholaris and Mentha piperata. Extracts of these plants have showed significant protection against radiationinduced syndromes (hematopoietic, gastrointestinal), as well as cellular and molecular damages in mice (Goyal and Gehlot 2009;Jindal et al 2010;Samarth et al 2004).…”

Section: Botanical and Herbal Extractsmentioning

confidence: 99%

Appraisal of biochemical classes of radioprotectors: evidence, current status and guidelines for future development

Mishra

2017

3 Biotech

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The search for efficient radioprotective agents to protect from radiation-induced toxicity, due to planned or accidental radiation exposure, is still ongoing worldwide. Despite decades of research and development of widely different biochemical classes of natural and derivative compounds, a safe and effective radioprotector is largely unmet. In this comprehensive review, we evaluated the evidence for the radioprotective performance of classical thiols, vitamins, minerals, dietary antioxidants, phytochemicals, botanical and bacterial preparations, DNA-binding agents, cytokines, and chelators including adaptogens. Where radioprotection was demonstrated, the compounds have shown moderate dose modifying factors ranging from 1.1 to 2.7. To date, only few compounds found way to clinic with limited margin of dose prescription due to side effects. Most of these compounds (amifostine, filgratism, pegfilgrastim, sargramostim, palifermin, recombinant salmonella flagellin, Prussian blue, potassium iodide) act primarily via scavenging of free radicals, modulation of oxidative stress, signal transduction, cell proliferation or enhance radionuclide elimination. However, the gain in radioprotection remains hampered with low margin of tolerance. Future development of more effective radioprotectors requires an appropriate nontoxic compound, a model system and biomarkers of radiation exposure. These are important to test the effectiveness of radioprotection on physiological tissues during radiotherapy and field application in cases of nuclear eventualities.

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“…ROE treatment before irradiation caused a significant depletion in LPO and elevation in GSH levels. [72][73][74][75] The dried fruit extract from Xylopia aethiopica (XA) increased the antioxidant defence systems in the liver, kidney, brain and testis of irradiated animals, and may protect from adverse effects of the whole body radiation. [76][77][78] Hippophae rhamnoides (Sea Buckthorn), has been reported to exhibit significant radioprotection against whole body lethal irradiation by preventing radiation induced DNA damage.…”

Section: Miscellaneousmentioning

confidence: 99%

A review of radioprotective plants

Bhandari¹

2013

Int J Green Pharm

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Radioprotective compounds have been used to diminish morbidity or mortality produced by ionizing irradiation. Initial developments of such agents concentrated on thiol synthetic compounds, like amifostine. This agent decreased mortality; however, there were difficulties in administering aminothiols that led to adverse effects. Unfortunately, no ideal, safe synthetic radioprotectors are available to date; hence, the exploration for other sources, including plants, has been ongoing for several decades. A methodical screening strategy can offer leads to isolating prospective novel candidate drugs from plant sources, for alleviation of radiation injury. This article reviews some of the most promising plants, and their bioactive principles, that are extensively used in traditional systems of medicine, and which have rendered noteworthy radioprotection in both in vitro and in vivo model systems.

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Influence of Rosemarinus officinalis Extract on Radiation-Induced Intestinal Injury in Mice

Cited by 6 publications

References 0 publications

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

Diterpenes from rosemary (Rosmarinus officinalis): Defining their potential for anti-cancer activity

Appraisal of biochemical classes of radioprotectors: evidence, current status and guidelines for future development

A review of radioprotective plants

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