A review of radioprotective plants

Bhandari, PrasanR

doi:10.4103/0973-8258.116379

Cited by 14 publications

(4 citation statements)

References 67 publications

(68 reference statements)

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“…For examples, the BALB/c mice have a double-stranded DNA repair defect that may account for their enhanced radiosensitivity [147] , and thymocytes, splenocytes and crypt cells of the C57BL/6 mice are more sensitive to IR-induced apoptosis than those of the C3H/HeN mice [148] . In many studies, in particular those using the in vitro models, the intermediate biomarkers of damage or protection, such as those regarding to the lipid peroxidation or antioxidant activity including glutathione, catalase, and glutathione peroxidase, and as well as the expression of genes that are related to radiation effects, such as p53 down stream genes, nuclear factor-kappa B (NFkB) and caspases, are used to evaluate the radioprotective effect of the candidate agent [149][150][151][152] . As an agent capable of inhibiting lipid peroxidation and scavenging free radicals may act as a possible RA, testing lipid peroxidation for screening a potential RA and assay of alterations in free radicals and antioxidant status could also provide information regarding the radioprotective potential, in addition to the testing for DNA strand breaks, apoptosis, cell survival, micronucleation, chromosome aberration.…”

Section: Strategies For and Challenge Of Ra Randdmentioning

confidence: 99%

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

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The research and development (R&D) of radioprotective agents (RAs) have been conducting since seven decades ago, and the safety and protection against undesirable effects of ionizing radiation (IR) has become an important issue especially for the benefit of patients receiving the radiotherapy, in addition to the applications in nuclear industry, military, outer space exploration and accidental exposures. Although the technology advancement makes the radiotherapy a promising better treatment by maximizing the effect of IR to the cancer cells, there are still needs for improvement in minimizing the toxicity to the normal cells. Aiming at providing the new researchers in the radiation protection field with an overall view for R&D of the RAs, this mini-review elucidates in brief a general understanding of the IR and its effects on the cell, the concepts of radiotherapy and therapeutic ratio, the categories of RAs and their mechanisms, and discusses on the strategies and challenge for R&D of the RAs.

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Section: Strategies For and Challenge Of Ra Randdmentioning

confidence: 99%

Research and Development of Radioprotective Agents: A Mini-Review

Saaya

Katsube

Xie

et al. 2017

International Journal of Radiology

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“…Ionizing radiation is used in medical diagnostics, radiotherapy, and sterilization (Geri et al ., 2019). Despite advancements in clinical radiation treatment planning and delivery technologies, radiotherapy still has a high level of damage to normal tissues and organs (Bhandari, 2013). The effect of ionising radiations on living tissue is influenced by a variety of characteristics, including the total length of exposure, the source of radiation, the distance from the source, and the physical and metabolic properties of the living tissue.…”

Section: Introductionmentioning

confidence: 99%

COMPARATIVE RADIOPATHOLOGY OF MALE REPRODUCTIVE ORGANS IN SPRAGUE DAWLEY RATS ADMINISTERED WITHCurcuma longaANDOcimum sanctumAGAINST ACUTE GAMMA IRRADIATION

Thapru

Nair

Hoque

et al. 2022

Preprint

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The study was designed to evaluate the deleterious effects of acute lethal gamma irradiation on male reproductive organs of Sprague Dawley rats and the radioprotective potential by Curcuma longa and Ocimum sanctum in a experimental set up. Twenty five Male Spraque Dawley rats were taken and randomized into 5 groups (T1, T2, T3, T4, T5), Each group containing 5 animals. The groups were named as Group T1 (Negative Control), Group T2 (irradiation positive control), Group T3 (irradiation and Curcuma longa), Group T4 (irradiation and Ocimum sanctum), Group T5 (irradiation, Curcuma longa and Ocimum sanctum). The rats in groups T1 and T2 were given a daily dosage of normal saline for 14 days. Group T3 and T4 rats received aqueous extracts of Curcuma longa (40 mg/kg) and Ocimum sanctum (40 mg/kg), respectively, whereas group T5 rats received a combination of aqueous extracts of Curcuma longa (40 mg/kg) and Ocimum sanctum (40 mg/kg) for 14 days, prior to gamma irradiation. Animals of group T2, T3, T4, T5 were irradiated with 10 Gy of γ radiation on 15th day. Exposure of animals to 10 Gy gamma radiation resulted in significant decrease in body weight and testicular weight. Histopathological observations revealed testicular degenerative changes in the seminiferous tubules with primary spermatocytes being most affected and epididymis showed decreased spermatids density with cell debris in the lumen. Pretreatment with Curcuma longa at 40mg/kg for 14 days alleviated the radiation induced pathological changes in testis and epididymis. Curcuma longa demonstrated much better protective effect in combination with Ocimum sanctum in alleviating the radio pathological changes showing the possibility of synergistic effect. However, administration of Ocimum sanctum alone at 40mg/kg for 14 days did not reveal any significant radioprotective property after histomorphological evaluation. Gamma irradiation of 10 Gy induces severe radio pathological damage to organs of male reproductive system of Spraque Dawley rats. Pretreatment with Curcuma longa prior to radiotherapy may be effective in preventing radiation induced damage in the male reproductive organs. Better radioprotection can be achieved with the combination of Curcuma longa and Ocimum sanctum than using alone.

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“…Natural anti‐oxidation agents exist widely in herbs and fruits and mainly include flavonoids and polyenes that could be used as radioprotectors . Both of these agents have advantages of low toxicity and moderate efficacy, but display poor stability and bioavailability .…”

Section: Introductionmentioning

confidence: 99%

The protective effects of XH‐105 against radiation‐induced intestinal injury

Cheng

Dong

Hou

et al. 2019

J Cellular Molecular Medi

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Radiation‐induced intestinal injury is one of the major side effects in patients receiving radiation therapy. There is no specific treatment for radiation enteritis in the clinic. We designed and synthesized a new compound named XH‐105, which is expected to cleave into polyphenol and aminothiol in vivo to mitigate radiation injury. In the following study, we describe the beneficial effects of XH‐105 against radiation‐induced intestinal injury. C57BL/6J mice were treated by gavage with XH‐105 1 hour before total body irradiation (TBI), and the survival rate was monitored. Histological changes were examined, and survival of Lgr5 + intestinal stem cells Ki67 + cells, villi + enterocytes and lysozymes was determined by immunohistochemistry. DNA damage and cellular apoptosis in intestinal tissue were also evaluated. Compared to vehicle‐treated mice after TBI, XH‐105 treatment significantly enhanced the survival rate, attenuated structural damage of the small intestine, decreased the apoptotic rate, reduced DNA damage, maintained cell regeneration and promoted crypt proliferation and differentiation. XH‐105 also reduced the expression of Bax and p53 in the small intestine. These data suggest that XH‐105 is beneficial for the protection of radiation‐induced intestinal injury by inhibiting the p53‐dependent apoptosis signalling pathway.

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A review of radioprotective plants

Cited by 14 publications

References 67 publications

Research and Development of Radioprotective Agents: A Mini-Review

Research and Development of Radioprotective Agents: A Mini-Review

COMPARATIVE RADIOPATHOLOGY OF MALE REPRODUCTIVE ORGANS IN SPRAGUE DAWLEY RATS ADMINISTERED WITHCurcuma longaANDOcimum sanctumAGAINST ACUTE GAMMA IRRADIATION

The protective effects of XH‐105 against radiation‐induced intestinal injury

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