Influence of risk factors on stomal recurrence after total laryngectomy for laryngeal carcinomas: A meta-analysis

Wang, Zhiyi; Li, Ze-Qin; Ji, Han; Chen, Wei; Wu, Kunmin; Zhu, Minhui; Zheng, Hongliang

doi:10.4103/jcrt.jcrt_90_17

Cited by 11 publications

(4 citation statements)

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“…The ARHQ methodology checklist is applicable for observational studies, including 11 items with a yes/no/unclear response option: Yes would be scored 1, no or unclear was scored 0, and an individual study can have a maximum of 11 quality points. Studies were deemed to be low quality (0-3), moderate quality (4)(5)(6)(7), and high quality (8-11). 6,7…”

Section: Data Extractionmentioning

confidence: 99%

“…To the best of our knowledge, only 1 systematic review of this topic has been published, in 2013 in a Chinese journal, which reported that transglottic location, tumor T-staging, and preoperative tracheotomy were important risk factors of recurrence after total laryngectomy. 5 Discouragingly, authors from other countries cannot access this review due to the lack of an English version of this review. We wished to update the systematic review of this topic in English and provide the information for more authors in the world.…”

Section: Introductionmentioning

confidence: 99%

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Risk Factors of Stomal Recurrence After Laryngectomy: A Systematic Review and Meta-analysis

Mei

Huang

et al. 2017

Ann Otol Rhinol Laryngol

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Section: Data Extractionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Risk Factors of Stomal Recurrence After Laryngectomy: A Systematic Review and Meta-analysis

Mei

Huang

et al. 2017

Ann Otol Rhinol Laryngol

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“…PSR for laryngo-hypopharyngeal SCC is regarded, after distant metastases, as one of the most serious complications following TL, and is almost universally fatal [5]. Studies reported over the decades have identified several potential risk factors leading to PSR and many have proposed that the occurrence can and should be minimized if not prevented [6,7 ▪ ,8].…”

Section: Introductionmentioning

confidence: 99%

Peristomal recurrence following primary total laryngectomy: the enigma of the central compartment neck lymph nodes

Bradley¹

2022

Current Opinion in Otolaryngology &Amp; Head &Amp; Neck Surgery

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Purpose of reviewThe practice of primary total laryngectomy (TL) for advanced laryngo-hypopharyngeal cancer has significantly declined in the developed countries. The treatment options most frequently adopted have changed from open surgery to transoral laser or robotic approaches or nonsurgical (bio-chemo-) radiotherapy. Primary TL remains the treatment of choice in the developing world where healthcare resources are limited, especially for the treatment of cancer. Recent findingsPeristomal recurrence (PSR) is quite a serious complication, with an incidence of 6.6% from the published literature (mainly concerning the developed world), most diagnosed within 2 years, and associated with >80% mortality. The major risk factors include pretreatment tracheostomy, specific primary tumor subsites, positive surgical margins, and presence of nodal metastasis. The treatment options are limited and most success has been observed with surgery, especially when PSR is diagnosed at an early-stage, which is uncommon. Treatment of advanced-stage disease is usually palliative. Reduction and/or prevention of the known risk factors for PSR remain the goal when performing TL. In particular, central compartment (paraand pretracheal) lymph nodes dissection in case of large tumors with extra-laryngeal and/or subglottic extension or pretreatment tracheotomy plays a paramount role in PSR prevention. SummaryResearch is required to conclude the formulation of guidelines for proper dissection of the central compartment (level VI) lymph nodes as indicated either prophylactically or therapeutically during TL for preventing PSR.

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“…Additionally, peristomal recurrence is a severe complication and has a high mortality rate. [4][5][6] In this study, we aimed to understand the clinical features of PSSCC that may warrant a bilateral level VI lymph node dissection. To this end, we analyzed the clinical features and pathological presence or absence of level VI lymph node metastasis in patients with PSSCC.…”

Section: Introductionmentioning

confidence: 99%

Pathological Level VI Lymph Node Metastasis in Clinical N3b Pyriform Sinus Squamous Cell Carcinoma

Matsui

Iwae

Yamamura

et al. 2021

Ann Otol Rhinol Laryngol

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Objective: The frequency of metastasis to level VI lymph nodes in advanced pyriform sinus squamous cell carcinoma (PSSCC) is unknown. We intended to analyze the clinical features and pathological presence or absence of level VI lymph node metastasis in patients with PSSCC. Methods: The data of 270 patients with previously untreated hypopharyngeal squamous cell carcinoma from 2006 to 2016 were obtained. Patients who underwent pharyngolaryngectomy for the pyriform sinus subsite with a curative intent with level VI dissection were included. We retrospectively analyzed the clinical Tumor-Node (TN) status (TNM classification of malignant tumors, eighth edition) and the presence or absence of pathological level VI lymph node metastasis. Results: A total of 34 patients were included. Eight patients (24%) had pathological level VI lymph node metastasis. The rate of pathological level VI lymph node metastasis was directly proportional to the clinical N status ( P = .0002, Chi-square test for trend). In all, 5 patients with cN2b- 3 were classified as cN3b. Ipsilateral pathological level VI lymph node metastasis was observed in 1 patient, and bilateral metastasis was observed in 3 patients. There was no association between clinical T status or pyriform sinus apex invasion and pathological level VI metastasis (both P > .99, Fisher’s exact test). Conclusions: PSSCC with cN3b is prone to bilateral level VI metastasis. We recommend that patients with PSSCC with cN3b should undergo bilateral level VI lymph node dissection.

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Influence of risk factors on stomal recurrence after total laryngectomy for laryngeal carcinomas: A meta-analysis

Cited by 11 publications

References 0 publications

Risk Factors of Stomal Recurrence After Laryngectomy: A Systematic Review and Meta-analysis

Risk Factors of Stomal Recurrence After Laryngectomy: A Systematic Review and Meta-analysis

Peristomal recurrence following primary total laryngectomy: the enigma of the central compartment neck lymph nodes

Pathological Level VI Lymph Node Metastasis in Clinical N3b Pyriform Sinus Squamous Cell Carcinoma

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