Influence of Rapeseed Protein Hydrolysis Conditions on Animal Cell Growth in Serum-free Media Supplemented with Hydrolysates

Chabanon, G.; Chevalot, Isabelle; Harscoat, C.; Chenu, S.; Goergen, Jean‐Louis; Marc, Annie; Marc, Ivan

doi:10.1007/978-1-4020-5476-1_121

Cell Technology for Cell Products

DOI: 10.1007/978-1-4020-5476-1_121

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Influence of Rapeseed Protein Hydrolysis Conditions on Animal Cell Growth in Serum-free Media Supplemented with Hydrolysates

G. Chabanon

Isabelle Chevalot

C. Harscoat

et al.

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Applications and analysis of hydrolysates in animal cell culture

Lim

et al. 2021

Bioresour. Bioprocess.

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Animal cells are used in the manufacturing of complex biotherapeutic products since the 1980s. From its initial uses in biological research to its current importance in the biopharmaceutical industry, many types of culture media were developed: from serum-based media to serum-free to protein-free chemically defined media. The cultivation of animal cells economically has become the ultimate goal in the field of biomanufacturing. Serum serves as a source of amino acids, lipids, proteins and most importantly growth factors and hormones, which are essential for many cell types. However, the use of serum is unfavorable due to its high price tag, increased lot-to-lot variations and potential risk of microbial contamination. Efforts are progressively being made to replace serum with recombinant proteins such as growth factors, cytokines and hormones, as well as supplementation with lipids, vitamins, trace elements and hydrolysates. While hydrolysates are more complex, they provide a diverse source of nutrients to animal cells, with potential beneficial effects beyond the nutritional value. In this review, we discuss the use of hydrolysates in animal cell culture and briefly cover the composition of hydrolysates, mode of action and potential contaminants with some perspectives on its potential role in animal cell culture media formulations in the future.

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Applications and analysis of hydrolysates in animal cell culture

Lim

et al. 2021

Bioresour. Bioprocess.

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show abstract

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Influence of Rapeseed Protein Hydrolysis Conditions on Animal Cell Growth in Serum-free Media Supplemented with Hydrolysates

Cited by 1 publication

References 1 publication

Applications and analysis of hydrolysates in animal cell culture

Applications and analysis of hydrolysates in animal cell culture

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