Influence of radiant exposure and repetition rate in infrared neural stimulation with near-infrared lasers

Alemzadeh‐Ansari, Mohammad Javad; Ansari, Mohammad Ali; Zakeri, Mahdi; Haghjoo, Majid

doi:10.1007/s10103-019-02741-4

Cited by 10 publications

(4 citation statements)

References 24 publications

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“…In addition, previous studies on the neuromuscular junction of Caenorhabditis elegans have shown that the rapid temperature increase caused by pulsed IR irradiation can lead to a redistribution of membrane surface charges, and the resulting asymmetric excitation current leads to the depolarization of the cell membrane [76]. Therefore, the increase in membrane capacitance caused by the temperature increase may also be an important mechanism by which INM regulates neural activity [77].…”

Section: Increased Membrane Capacitancementioning

confidence: 99%

Advances in the Regulation of Neural Function by Infrared Light

Song,

Wang,

Peng

2024

IJMS

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In recent years, with the rapid development of optical technology, infrared light has been increasingly used in biomedical fields. Research has shown that infrared light could play roles in light stimulation and biological regulation. Infrared light has been used to regulate neural function due to its high spatial resolution, safety and neural sensitivity and has been considered a useful method to replace traditional neural regulation approaches. Infrared neuromodulation methods have been used for neural activation, central nervous system disorder treatment and cognitive enhancement. Research on the regulation of neural function by infrared light stimulation began only recently, and the underlying mechanism remains unclear. This article reviews the characteristics of infrared light, the advantages and disadvantages of infrared neuromodulation, its effects on improving individual health, and its mechanism. This article aims to provide a reference for future research on the use of infrared neural regulation to treat neuropsychological disorders.

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Section: Increased Membrane Capacitancementioning

confidence: 99%

Advances in the Regulation of Neural Function by Infrared Light

Song,

Wang,

Peng

2024

IJMS

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“…INS has been achieved with pulse durations in the range of microseconds [10], milliseconds [11], and seconds [8]. Moreover, the accumulation of heat caused by a sequence of light pulses at a repetition rate higher than 3 Hz could result in nerve responses of greater amplitude [12], [13]. However, former studies did not report an impact of the stimulation rate on the recorded compound action potential amplitude [7], [14].…”

Section: Introductionmentioning

confidence: 99%

Heat accumulation during infrared stimulation impacts the response of ex vivo rat sciatic nerve*

Perre,

Chávez Cerda,

Verstraeten

et al. 2023

2023 45th Annual International Conference of the IEEE Engineering in Medicine &Amp; Biology Society (EMBC)

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Infrared neural stimulation (INS) is a neuromodulation technique that involves short optical pulses delivered to the neural tissue, resulting in the initiation of action potentials. In this work, we studied the compound neural action potentials (CNAP) generated by INS in five ex vivo sciatic nerves. A 1470 nm laser emitting a sequence of 0.4 ms light pulses with a peak power of 10 W was used. A single 4 mJ stimulus is not capable of eliciting a nerve response. However, repetition of the optical stimuli resulted in the induction of CNAPs. Heat accumulation induced by repetition rates as high as 10 Hz may be involved in the increase in CNAP amplitude. This sensitization effect may help to reduce the pulse energy required to evoke CNAP. In addition, these results highlight the importance of investigating the role of the slow nerve temperature dynamics in INS. * Research supported by the Fonds Emile Defay. L.VP acknowledges the support of the Fonds pour la formation à la Recherche dans l'Industrie et dans l'Agriculture (FRIA, FNRS, Belgium).

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“…[1][2][3][4] While the safety and efficacy of INS have been demonstrated in various studies, the typical thresholds for INS to elicit neural responses varied significant. 5,6 This method provides several advantages over conventional electrical stimulation, including contact-free delivery, spatial precision, and lack of stimulation artifacts. [7][8][9] Shapiro et al and Wells et al have demonstrated that INS can be explained by the photothermal mechanism, 4-10 but the exact mechanism of INS is under discussion in the literature.…”

Section: Introductionmentioning

confidence: 99%

“…4 This rapid increase in temperature can be modeled by the heat diffusion equation. 5 Here, we analytically solved this equation -by applying an appropriate Green function -to simulate the distribution of deposited thermal energy inside a biological phantom induced by a train of the infrared pulse laser. Then these results were verified by experimental results.…”

Section: Introductionmentioning

confidence: 99%

Blind Localization of Heating in Neural Tissues Induced by a Train of the Infrared Pulse Laser

Ansari

Zakeri

2019

J Lasers Med Sci

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Introduction: Recently, infrared lasers (wavelengths larger than 1100 nm) have been applied to stimulate neural tissues. Infrared neural stimulation (INS) has some advantages over conventional electric stimulation, including contact-free delivery, spatial precision, and lack of stimulation artifacts. In this study and based on a photothermal mechanism, we applied the heat diffusion equation to study temperature variation of a biological phantom during INS. In addition, the impact of laser parameters on spatially localized heating induced by 2 different infrared wavelengths were studied. Methods: We studied the localization of INS inside a phantom similar to cortical neural tissue. First, we analytically solved the heat diffusion equation to study the distribution of temperature inside this phantom. Then, the accuracy of analytical results was verified by heating the phantom using amplitude-modulated infrared lasers (lambda= 1450 and 1500 nm, the energy between 2 and 5 mJ and pulse duration up to 20 ms). The laser light was directed to sample by a multimode optical fiber (NA=0.22, core size= 200 microns). Finally, the impacts of laser properties on the spatial resolution of infrared heating were discerned. Results: In order to verify analytical results, we measured the maximum temperatures of the phantom during illumination of lasers and compared them with analytical results. The analytical results were in agreement with the experimental results. The effects of laser beam properties such as pulse duration, energy and repetition rate frequency on the spatial resolution were investigated. The results indicated that the spatial resolution of INS can be smaller than one millimeter. Conclusion: Here, the influences of laser properties on the localization of INS inside a biological phantom were studied. These results can be applied to improve the spatial selectivity of the peripheral nerve interface.

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Influence of radiant exposure and repetition rate in infrared neural stimulation with near-infrared lasers

Cited by 10 publications

References 24 publications

Advances in the Regulation of Neural Function by Infrared Light

Advances in the Regulation of Neural Function by Infrared Light

Heat accumulation during infrared stimulation impacts the response of ex vivo rat sciatic nerve*

Blind Localization of Heating in Neural Tissues Induced by a Train of the Infrared Pulse Laser

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