Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes

Nasser, Soumana C.; Slim, Mahmoud; Nassif, Jeanette G.; Nasser, Selim M.

doi:10.3748/wjg.v21.i15.4599

Cited by 23 publications

(23 citation statements)

References 34 publications

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“…The most frequent reason for these atypical gastritis is the consumption of PPI or previous eradication treatment . PPI were introduced 25 years ago and changed the paradigm of H. pylori gastritis promoting the diagnosis of apparently H. pylori negative inactive chronic gastritis . The concept of the utility of ancillary stains for H. pylori in atypical gastritis was also proposed in another study …”

Section: Invasive Testsmentioning

confidence: 99%

“…26 PPI were introduced 25 years ago and changed the paradigm of H. pylori gastritis promoting the diagnosis of apparently H. pylori negative inactive chronic gastritis. 27 The concept of the utility of ancillary stains for H. pylori in atypical gastritis was also proposed in another study. 28 The use of digital pathology was compared to the standard glass slide microscopy on specimens of various origins, 13.4% were issued from the gastrointestinal tract with an excellent correlation.…”

Section: Histologymentioning

confidence: 99%

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Diagnostic of Helicobacter pylori infection

et al. 2016

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There is progress in endoscopy techniques. While it is not yet possible to detect Helicobacter pylori directly in the stomach, it becomes easier to detect the mucosal changes induced by the bacteria. Some small changes can also increase the sensitivity of the invasive tests, for example culture or histology, but the wide use of proton-pump inhibitors has a negative impact on these tests. Only molecular methods are able to detect a limited load of bacteria, especially by using real-time PCR but also with new methods, for example dual-priming oligonucleotide-based PCR, loop-medicated isothermal amplification, droplet-digital PCR or a multiple genetic analysis system. Among the noninvasive tests, urea breath test remains a test of major interest, while there are attempts to develop an ammonia breath test and other nanosensor devices. A new antigen stool test, a chemoluminescence immunoassay using the LIAISON apparatus has also been tested for the first time with success. Despite its limitations, serology remains the most popular test to detect H. pylori antibodies. It also allows pepsinogen dosage which is of interest for detecting atrophy.

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Section: Invasive Testsmentioning

confidence: 99%

Section: Histologymentioning

confidence: 99%

Diagnostic of Helicobacter pylori infection

et al. 2016

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“…This wide variation is probably due not only to different population characteristics but mainly to different criteria used for the diagnosis of chronic gastritis. Nonetheless, the diagnosis of chronic gastritis may be significant in some populations, as it may suggest the possibility of H. pylori infection that is masked by the use of proton pump inhibitors [ 16 ]. The rate of intestinal metaplasia is also variable among studies but does not exceed 3.1% [ 3 , 5 , 7 , 8 , 11 , 12 ].…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Prevalence in Laparoscopic Sleeve Gastrectomy Specimen

Sabbah

Saoud

Deeb

et al. 2020

Gastroenterology Research and Practice

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Introduction. Laparoscopic sleeve gastrectomy (LSG) has become a common surgical procedure. The value of routine histopathologic examination of the LSG specimens remains, however, a controversial issue. Helicobacter pylori was the most prevalent finding in several previous studies, but the overall results were dissimilar. We aim to assess the prevalence of Helicobacter pylori and other histopathologic findings in LSG specimens and the effect of increasing the number of sections for histology, from LSG specimens, on the rates of abnormal findings. Methods. We retrospectively reviewed the histopathologic data of all patients who had undergone LSG, in a tertiary care center, over a 4-year period ( n = 481 ). Patient characteristics and histopathologic findings were recorded and analyzed. Results. Inactive chronic gastritis was the most common histopathologic finding (62.16%) followed by Helicobacter pylori gastritis (35.34%). Intestinal metaplasia was identified in 1.66% of the cases. There was no diagnosis of malignancy. Increasing the number of sections submitted for histopathologic examination resulted in a significantly higher rate of H. pylori gastritis detection. Conclusion. Routine histopathologic examination of LSG specimens may detect H. pylori in a significant proportion of patients, and increasing the number of sections for histology from LSG specimens improves the rate of detection of this bacterium and identifies individuals who may benefit from treatment.

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“…PCR is more sensitive as the grade of atrophy and/or IM progress toward malignancy[48]. Moreover, the accuracy of histopathology identification of H. pylori is affected by PPI and antibiotic use, which were not an exclusion criteria for these studies[49,50].…”

Section: Gastric Histopathology In Dyspeptic Patientsmentioning

confidence: 99%

Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana

Archampong

Asmah

Richards

et al. 2019

WJG

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Gastroduodenal disease (GDD) was initially thought to be uncommon in Africa. Amongst others, lack of access to optimal health infrastructure and suspicion of conventional medicine resulted in the reported prevalence of GDD being significantly lower than that in other areas of the world. Following the increasing availability of flexible upper gastro-intestinal endoscopy, it has now become apparent that GDD, especially peptic ulcer disease (PUD), is prevalent across the continent of Africa. Recognised risk factors for gastric cancer (GCA) include Helicobater pylori ( H. pylori ), diet, Epstein-Barr virus infection and industrial chemical exposure, while those for PUD are H. pylori , non-steroidal anti-inflammatory drug (NSAID)-use, smoking and alcohol consumption. Of these, H. pylori is generally accepted to be causally related to the development of atrophic gastritis (AG), intestinal metaplasia (IM), PUD and distal GCA. Here, we perform a systematic review of the patterns of GDD across Africa obtained with endoscopy, and complement the analysis with new data obtained on pre-malignant gastric his-topathological lesions in Accra, Ghana which was compared with previous data from Maputo, Mozambique. As there is a general lack of structured cohort studies in Africa, we also considered endoscopy-based hospital or tertiary centre studies of symptomatic individuals. In Africa, there is considerable heterogeneity in the prevalence of PUD with no clear geographical patterns. Furthermore, there are differences in PUD within-country despite universally endemic H. pylori infection. PUD is not uncommon in Africa. Most of the African tertiary-centre studies had higher prevalence of PUD when compared with similar studies in western countries. An additional intriguing observation is a recent, ongoing decline in PUD in some African countries where H. pylori infection is still high. One possible reason for the high, sustained prevalence of PUD may be the significant use of NSAIDs in local or over-the-counter preparations. The prevalence of AG and IM, were similar or modestly higher over rates in western countries but lower than those seen in Asia. . In our new data, sampling of 136 patients in Accra detected evidence of pre-malignant lesions (AG and/or IM) in 20 individuals (14.7%). Likewise, the prevalence of pre-malignant lesions, in a sample of 109 patients from Maputo, were 8.3% AG and 8.3% IM. While H. pylori is endemic in Africa, the observed prevalence for GCA is rather low. However, cancer data is drawn from country cancer registries that are not comprehensive due to considerable variation in the availability of efficient local cancer reporting systems, diagnostic health facilities and expertise. Validation of cases and their source as well as specificity of outcome definitions are not explicit in most studies further contributing to uncertainty about the precise incidence rates of G...

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Influence of proton pump inhibitors on gastritis diagnosis and pathologic gastric changes

Cited by 23 publications

References 34 publications

Diagnostic of Helicobacter pylori infection

Diagnostic of Helicobacter pylori infection

Helicobacter pylori Prevalence in Laparoscopic Sleeve Gastrectomy Specimen

Gastro-duodenal disease in Africa: Literature review and clinical data from Accra, Ghana

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