Influence of prostaglandins (PG) E2 and F2α on the inflammatory process

DiPasquale, G.; Rassaert, Charles L.; Richter, Robert P.; Welaj, P; Tripp, Lloyd D.

doi:10.1016/0090-6980(73)90001-4

Cited by 27 publications

(5 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exogenously administered E-type prostaglandins (PGE) in high doses have been shown to suppress adjuvant-induced arthritis in rats (Aspinall and Cammarata, 1969;Zurier and Quagliata, 1971;Glenn and Rohloff, 1972;DiPasquale et al, 1973;Zurier et al, 1973). In vitro, PGE increased the level of cyclic 3', 5'-adenosine monophosphate (cAMP) in leucocytes and this effect was associated with inhibited release of lysosomal enzymes from phagocytic cells (Scott, 1970;Weissmann, 1972;Weissmann et al, 1976;Lichtenstein et al, 1972).…”

mentioning

confidence: 99%

Combination of theophylline and prostaglandin E1 as inhibitors of the adjuvant-induced arthritis syndrome of rats.

Bonta¹,

Parnham²,

Vliet³

1978

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

SUMMARY The effects of daily subcutaneous administration of prostaglandin E1 (PGE,), theophylline, and of both drugs together were studied on the Freund's adjuvant-induced inflammatory and arthritic syndrome in rats. In the doses used, neither drug affected the acute inflammatory response in the adjuvant-treated paw, but together they caused marked inhibition. Chronic inflammation in the contralateral (nontreated) hind paws was slightly inhibited by each drug and combined treatment resulted in marked inhibition. The drugs also counteracted splenomegaly in adjuvantdiseased rats and their effects on spleen weight paralleled the inhibition of chronic inflammation. Arthritic lesions, as judged by x-rays of tibiotarsal joint destruction in the nontreated paws, were partially prevented by PGE1 alone, but not by theophylline. The combined treatment entirely prevented these joint lesions. PGE1 did not cause an increase in adrenal weight, but enhanced the effect of theophylline on adrenal weight. Only PGE1 improved gait in arthritic rats, simultaneous theophylline treatment having little additional effect.Other workers have found that PGE1 increases intracellular cAMP and that this effect is enhanced by the phosphodiesterase inhibitor, theophylline. We propose that the anti-inflammatory and antiarthritic effects of combined drug treatment involve cAMP changes in phagocytic cells at the site of tissue injury and in systemic lymphocytes.

show abstract

mentioning

confidence: 99%

Combination of theophylline and prostaglandin E1 as inhibitors of the adjuvant-induced arthritis syndrome of rats.

Bonta¹,

Parnham²,

Vliet³

1978

Annals of the Rheumatic Diseases

View full text Add to dashboard Cite

show abstract

“…Urate crystals heated to 200 °C produced less swelling in normal rats than did similar urate crystals heated only to 50 °C. However when a 1-ng dose o f PGE,, PGE, or PGF2a was added to the heated urate crystals injection the swelling increased to approximately the swelling in normal controls receiving urate heated to 50 °C.Comments are presented suggesting that urate crystal inflammation may be a mem brane disease.Among the numerous metabolic effects of prostaglandins (PGs) are those related to mediation and control of inflammation (DiPasquale, 1973; Glenn et ai, 1972;Kaley and Wiener, 1971). Recently I have demonstrated that a physiologic amount of PGE) promotes inflammation in urate crystal deposition disease {Denko, 1974), a widely used experimental mod-…”

mentioning

confidence: 99%

Effect of Prostaglandins in Urate Crystal Inflammation

Denko¹

1974

Pharmacology

View full text Add to dashboard Cite

By use of two novel techniques for detecting extremely small amounts of PGs, studies were conducted elucidating the mechanism of urate crystal-induced inflammation. Rats deficient in EFA and thus deficient in PGs received injections of monosodium urate crystals into the footpad. The EFA-deficient animals developed less swelling than did normal animals. However, when a 1-ng dose of PGE₁ PGE₂, PGA₂ or PGF₂_α was added along with the urate injection the swelling was enhanced to approximately normal levels. In the second technique the swelling induced by injection of two different urate crystals was compared. Urate crystals heated to 200 °C produced less swelling in normal rats than did similar urate crystals heated only to 50 °C. However when a 1-ng dose of PGE₁ PGE₂ or PGF2_α was added to the heated urate crystals injection the swelling increased to approximately the swelling in normal controls receiving urate heated to 50 °C. Comments are presented suggesting that urate crystal inflammation may be a membrane disease.

show abstract

“…Just as support for the hypothesis that platelets play a role in inflammation rests heavily on the fact that platelets produce prostaglandin E2 which causes inflammation, so an argument against this hypothesis is that, PGE2 exhibits anti-inflammatory effects in some experiments in animals [45,46,47]. However, GLENN and ROHLOFF [46] point out that high pharmacologic doses of prostaglandins were required in their studies to obtain anti-inflammatory effects.…”

Section: Arguments Against the Hypothesismentioning

confidence: 99%

Blood platelets and the inflammatory process

1974

View full text Add to dashboard Cite

There appears to be an encouraging body of evidence supporting a relationship between hemostasis and inflammation with the platelet being the main link between the two.These processes are both triggered by damage to blood vessels and a response which occurs within seconds of this damage is the adhesion of platelets to the injured tissue and to each other. During the hemostatic process inflammatory agents are released from platelets.Some anti-inflammatory agents such as aspirin also have anti-hemostatie properties and this seems to be because they act on platelets. During platelet aggregation, platelets synthesize the potent inflammatory agent prostaglandin E2 and its formation is prevented by aspirin. Only a few years

show abstract

Influence of prostaglandins (PG) E2 and F2α on the inflammatory process

Cited by 27 publications

References 35 publications

Combination of theophylline and prostaglandin E1 as inhibitors of the adjuvant-induced arthritis syndrome of rats.

Combination of theophylline and prostaglandin E1 as inhibitors of the adjuvant-induced arthritis syndrome of rats.

Effect of Prostaglandins in Urate Crystal Inflammation

Blood platelets and the inflammatory process

Contact Info

Product

Resources

About