Blood platelets and the inflammatory process

Silver, Melvin J.; Bryan, Joseph; Ingerman, Carol M.

doi:10.1007/bf01965226

Cited by 28 publications

(7 citation statements)

References 38 publications

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“…The elucidation of the pattern of reactions that constitute the different phases of the inflammatory response has shown that in many points these reactions are similar to those occurring during platelet aggregation [1][2][3]. One of the important questions is, whether platelets play a role in the early phases of the inflammation.…”

Section: Introductionmentioning

confidence: 99%

Accumulation of blood platelets in carrageenin rat paw oedema. Possible role in the inflammatory process

1978

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The accumulation of blood platelets in the carrageenin-induced paw oedema in rats was studied, using 51Cr-labeled platelets. A maximum in the accumulation was seen after 4 hours, followed by a decline after 5--6 hours. During the first 6 hours of the oedema formation, change in blood volume were small. A comparison was made with the accumulation of both 125J-albumin as a measure of extravasation and 125J-fibrinogen as an indication of blood clotting. When platelet aggregation was measured during the first 6 hours of the oedema formation, the lag time between the addition of collagen and the beginning of the aggregation was increased. No change in platelet serotonin was seen. These data support the idea that platelets participate in the inflammatory process.

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Section: Introductionmentioning

confidence: 99%

Accumulation of blood platelets in carrageenin rat paw oedema. Possible role in the inflammatory process

1978

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“…On the basis of the present work, the predictive value of an inhibition of platelet PG synthesis for anti-inflammatory activity is questionable. The involvement of platelets in the inflammatory process especially as a source of PG synthetase, has been considered by SILVER et al [10] and VINCENT et al [11]. Our results suggest that an inhibition of platelet function, although not necessarily via an inhibition of platelet PG synthesis, may bear a relationship to anti-inflammatory activity.…”

Section: Discussionmentioning

confidence: 48%

Relationship of inhibition of prostaglandin synthesis in platelets to anti-aggregatory and anti-inflammatory activity of some benzoic acid derivatives

Cerskus

Philp

1981

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The relationships between inhibition of platelet prostaglandin (PG) synthesis and aggregation, and suppression inflammation were investigated with a number of benzoic acid (aspirin-like) chemicals. The compounds studied were 2-acetylbenzoic acid (ABA), 3-methylphthalide (3-MP), 3-propionyloxybenzoic acid (3-PBA) and 2-propionyloxybenzoic acid (2-PBA). At 0.5--0.6 mM, 3-MP inhibited the second phase of ADP-induced aggregation in human platelets, and reduced collagen-induced aggregation by 50%. Previous studies have shown 2-PBA to inhibit aggregation at similar concentrations. In contrast, ABA required 10 times higher concentrations, and low concentrations actually potentiated aggregation. Inhibition of PG synthesis from 14C-arachidonic acid (AA) by human platelets was shown for 2-PBA, but not to 3-BPA, or ABA. At high concentration (1 mM), 3-MP showed modest inhibitory activity. Significant inhibition of AA aggregation was produced by ASA (83%), 2-PBA (76%) and 3-MP (69%), an order reflecting their inhibition of PG synthesis, where ABA and 3-PBA did not inhibit AA aggregation. Carrageenin-induced edema of the rat paw was suppressed by 3-MP, ABA and 2-PBA; all being roughly equipotent with aspirin. In contrast, 3-PBA did not suppress edema. Following oral administration of the drugs to rats, PG synthesis from labeled AA by rat platelets showed similar profiles to effects of the drugs on PG synthesis in human platelets. This suggests that biotransformation or species differences are not explanations for the observed differences in activity in the various test systems. The results indicate that, in a related series of chemicals there is not a good correlation between ability to inhibit platelet PG synthesis, anti-aggregatory activity and anti-inflammatory activity. Multiple mechanisms of action, differing sensitivities of various tissue PG synthetases, or unidentified factors could be involved.

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“…Important reactions are induced through their interference with the activation cascade of the complement [14,19], the kinin [2] and the fibrinolytic [9] system.…”

Section: Diseussionmentioning

confidence: 99%

Modulation of natural and interleukin-2-induced tumour-cytolytic activities by the members of a protein family related to β-thromboglobulin

Klein-Struckmeier

Knüver-Hopf

Mohr

1991

Cancer Immunol Immunother

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A preparation of three C-terminal fragments of the platelet protein beta-thromboglobulin was previously described to have immunomodulatory properties on phagocytic cells. One of the components is obviously identical to the recently described neutrophil-activating peptide 2 (NAP-2). In further investigations on this protein preparation (called factor C) we are able to show an additional influence on the tumour-cytolytic activities of mononuclear cells. Total neutralization of the factor C effect, by treating a factor C preparation with specific monoclonal antibody C24 prior to application in cell culture, proved that the effect is really restricted to factor C proteins. If factor C is given in combination with natural interleukin-2 (IL-2) a dose-dependent suppression of IL-2-mediated natural killer lymphokine-activated killer activity can be measured, which is first detectable 72 h after addition of factor C. Suppression does not occur if the both factors are added within a time interval of more than 12 h. Depletion of monocytes from mononuclear cells has no effect on factor-C-mediated cytotoxicity, demonstrating that factor C acts directly on lymphoid cells.

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Blood platelets and the inflammatory process

Cited by 28 publications

References 38 publications

Accumulation of blood platelets in carrageenin rat paw oedema. Possible role in the inflammatory process

Accumulation of blood platelets in carrageenin rat paw oedema. Possible role in the inflammatory process

Relationship of inhibition of prostaglandin synthesis in platelets to anti-aggregatory and anti-inflammatory activity of some benzoic acid derivatives

Modulation of natural and interleukin-2-induced tumour-cytolytic activities by the members of a protein family related to β-thromboglobulin

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