Influence of processing parameters on mechanical properties of a 3D‐printed trabecular bone microstructure

Amini, Morteza; Reisinger, Andreas; Pahr, Dieter H.

doi:10.1002/jbm.b.34363

Cited by 15 publications

(6 citation statements)

References 71 publications

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“…The essence of tissue engineering is producing a protective structure targeting damaged tissues, using viable cells at an appropriate tissue culture system, which may add substances to stimulate cellular response [Amini et al,2020]. Bone tissue is the focus of many tissue engineering studies, consisting mainly of hydroxyapatite and proteins such as collagen, fibrillin, and other cell stimulators.…”

Section: Introductionmentioning

confidence: 99%

Polycaprolactone/Beta-Tricalcium Phosphate Scaffolds Obtained via Rotary Jet-Spinning: in vitro and in vivo Evaluation

Pinto

Dias

Cardoso

et al. 2021

Cells Tissues Organs

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This study aimed to evaluate in vitro and in vivo polymeric membranes obtained by a rotary jet-spinning process for the repair of critical bone defects in the calvaria of Wistar rats, for future use in tissue engineering. Experimental sample collections were performed on the 30, 60 and 90th postoperative days, and the analyses performed were histomorphometric, immunohistochemistry, and western blotting. Reducing inflammatory infiltrate in all groups and experimental periods, angiogenesis on the 30th day did not show any difference between the groups, on the 60th day, 5% polycaprolactone/beta-tricalcium phosphate(PCL/β-TCP) was high compared to control (C), and on the 90th day, the same group reduced when compared to C and 10% PCL/β-TCP. The fibroplasia presented oscillations in every segment; on the 30th and 60th day, there was an increase in 5% PCL/β-TCP, which decreased by the 90th day compared to group C. 10% PCL/β-TCP decreased compared to C on the 60th and 90th day. The percentage of the collagen area remained high in all groups and all experimental periods. Immunohistochemistry quantifications showed variations in bone metabolism suggesting new bone formation. The 5 and 10% PCL/β-TCP scaffold were promising for the bone regeneration process because they participated in the modulation of inflammation, angiogenesis, fibroplasia, and collagenosis.

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Section: Introductionmentioning

confidence: 99%

Polycaprolactone/Beta-Tricalcium Phosphate Scaffolds Obtained via Rotary Jet-Spinning: in vitro and in vivo Evaluation

Pinto

Dias

Cardoso

et al. 2021

Cells Tissues Organs

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“…The golden standard was to test the skeletal samples from cadavers or experimental animals; however, cadavers involve high cost and ethical issues and operation on experimental animals is challenging at the millimetre scale, limiting their applicability. 3DP [2,[34][35][36][37] and micro-CT based FE modelling [38][39][40][41][42][43] have been utilised to investigate the mechanical behaviour of trabeculae under different loading conditions and have shown an excellent prediction. Before testing 3DP VOI trabeculae, the key objective was to ensure that the 3D printer could accurately reproduce trabecular samples [36].…”

Section: Discussionmentioning

confidence: 99%

Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method

Zheng

Dai

Zheng³

et al. 2022

BioMed Eng OnLine

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Background Medial compartment knee osteoarthritis (KOA) accounts for most KOA cases, and increased trabecular bone volume fraction (BV/TV) is one of the pathological changes in the tibial plateau of KOA. How BV/TV changes before and after the menopause and its effects on medial compartment KOA are yet to be clarified. Methods Twenty femurs from twenty 12-week-old rats were included. The operated group underwent ovariectomy (to represent the osteoporosis condition), called the O group, and the non-operated group was the normal control, called the N group. Micro-CT scans of the femoral condyles were acquired 12 weeks after the surgery, and the volume of interest (VOI) of medial-, inter-, and lateral-condyle trabeculae were three-dimensional (3D) printed for uniaxial compression mechanical test and simulated by the finite element (FE) method. Results The results demonstrated that the O group indicated poorer trabecular architecture than the N group in three parts of the femoral condyle, especially in the intercondyle. Within the group, the BV/TV, trabecular thickness (Tb.Th), and trabecular number (Tb.N) ratios between the medial and lateral condyles were greater than 1 in both N and O groups. The medial condyle trabeculae's mechanical properties were higher than those of the lateral condyle, and this superiority appears to be broadened under osteoporotic conditions. FE modelling well reproduced these mechanical differentiations. Conclusions According to Wolff's law, the higher BV/TV and mechanical properties of the medial femoral condyle may be due to inherent imbalanced loading on the knee component. Alterations in BV/TV and their corresponding mechanical properties may accompany KOA.

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“…In vitro tests showed decent viability of osteoblasts on these scaffolds, as well as enhanced differentiation. Another study acquired templates from the distal radius trabecular bone [ 183 ]. The influence of 3D printing parameters, including input-image resolution, boundary condition, support material, STL mesh decimation, and repetition parameters on mechanical properties, were thoroughly investigated.…”

Section: The Fabrication Flow Of Customized Am Bone Scaffoldsmentioning

confidence: 99%

Customized Additive Manufacturing in Bone Scaffolds—The Gateway to Precise Bone Defect Treatment

Zhou,

See,

Sreenivasamurthy

et al. 2023

Research

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In the advancing landscape of technology and novel material development, additive manufacturing (AM) is steadily making strides within the biomedical sector. Moving away from traditional, one-size-fits-all implant solutions, the advent of AM technology allows for patient-specific scaffolds that could improve integration and enhance wound healing. These scaffolds, meticulously designed with a myriad of geometries, mechanical properties, and biological responses, are made possible through the vast selection of materials and fabrication methods at our disposal. Recognizing the importance of precision in the treatment of bone defects, which display variability from macroscopic to microscopic scales in each case, a tailored treatment strategy is required. A patient-specific AM bone scaffold perfectly addresses this necessity. This review elucidates the pivotal role that customized AM bone scaffolds play in bone defect treatment, while offering comprehensive guidelines for their customization. This includes aspects such as bone defect imaging, material selection, topography design, and fabrication methodology. Additionally, we propose a cooperative model involving the patient, clinician, and engineer, thereby underscoring the interdisciplinary approach necessary for the effective design and clinical application of these customized AM bone scaffolds. This collaboration promises to usher in a new era of bioactive medical materials, responsive to individualized needs and capable of pushing boundaries in personalized medicine beyond those set by traditional medical materials.

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Influence of processing parameters on mechanical properties of a 3D‐printed trabecular bone microstructure

Cited by 15 publications

References 71 publications

Polycaprolactone/Beta-Tricalcium Phosphate Scaffolds Obtained via Rotary Jet-Spinning: in vitro and in vivo Evaluation

Polycaprolactone/Beta-Tricalcium Phosphate Scaffolds Obtained via Rotary Jet-Spinning: in vitro and in vivo Evaluation

Medial tibial plateau sustaining higher physiological stress than the lateral plateau: based on 3D printing and finite element method

Customized Additive Manufacturing in Bone Scaffolds—The Gateway to Precise Bone Defect Treatment

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