Influence of probiotics on Candida presence and IgA anti-Candida in the oral cavity

Santos, Agda Lima dos; Jorge, Antônio Olavo Cardoso; Santos, Silvana Soléo Ferreira dos; Silva, Célia Regina Gonçalves e; Leão, Mariella Vieira Pereira

doi:10.1590/s1517-83822009000400030

Cited by 28 publications

(23 citation statements)

References 5 publications

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“…Hatakka and coworkers (2007) reported a reduced prevalence of high salivary counts of yeast after intake of a multistrain probiotic cheese. This was confirmed in 2 later studies following consumption of yogurt containing lactobacilli and bifidobacteria species (Dos Santos et al 2009;Mendonça et al 2012). These findings were based on dietary interventions, and to our knowledge, the concept of lozenges for the local administration of probiotics has not been evaluated.…”

Section: Introductionmentioning

confidence: 63%

Effect of Probiotic Bacteria on Oral Candida in Frail Elderly

et al. 2015

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The aim of this study was to investigate the effect of a daily intake of probiotic lactobacilli on the prevalence and counts of oral Candida in frail elderly patients living in nursing homes. The study had a double-blind randomized placebo-controlled design with 2 parallel arms. The study group consisted of 215 older adults (range, 60 to 102 y) who were enrolled after informed consent. After baseline examination and randomization, the subjects were given 1 lozenge containing 2 strains of the probiotic bacterium Lactobacillus reuteri (DSM 17938 and ATCC PTA 5289) or placebo twice daily (morning and evening). The intervention period was 12 wk, and saliva and plaque samples were collected at baseline and follow-up. The primary end point was prevalence of high Candida counts assessed from chairside tests. Secondary end points were levels of dental plaque and gingival inflammation. The groups were balanced at baseline. The attrition rate to follow-up was 19%. There was a statistically significant reduction in the prevalence of high Candida counts in the probiotic group but not in the placebo group, and the difference was statistically significant in both saliva and plaque (P < 0.05). No significant differences between the groups were noted concerning the levels of supragingival plaque or bleeding on probing. Thus, daily use of probiotic lozenges may reduce the prevalence of high oral Candida counts in frail elderly nursing homes residents (ClinicalTrials.gov NCT02391532).

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Section: Introductionmentioning

confidence: 63%

Effect of Probiotic Bacteria on Oral Candida in Frail Elderly

et al. 2015

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“…Lactobacilli, as probiotic agents, are believed to interfere with pathogens by different mechanisms (22,30). One of its mechanisms is biosurfactant production.…”

Section: Introductionmentioning

confidence: 99%

Lactobacillus acidophilus-derived biosurfactant effect on gtfB and gtfC expression level in Streptococcus mutans biofilm cells

Tahmourespour¹,

Salehi²,

Kermanshahi³

2011

Braz. J. Microbiol.

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Streptococcus mutans (S. mutans), harboring biofilm formation, considered as a main aetiological factor of dental caries. Gtf genes play an important role in S. mutans biofilm formation. The purpose of this study was to investigate the effect of Lactobacillus acidophilus-derived biosurfactant on S. mutans biofilm formation and gtfB/C expression level (S. mutans standard strain ATCC35668 and isolated S. mutans strain (22) Several properties of S. mutans cells (the surface properties, biofilm formation, adhesion ability and gene expression) were changed after L. acidophilus-derived biosurfactant treatment. It is also concluded that biosurfacant treatment can provide an optional way to control biofilm development. On the basis of our findings, we can suggest that the prepared biosurfactant may interfere with adhesion processes of S. mutans to teeth surfaces, provided additional evaluation produce satisfactory results.

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“…Estudos prévios têm demonstrado que o consumo de alimentos probióticos pode reduzir a quantidade de Candida na microbiota normal dos seres humanos, podendo auxiliar no controle da candidíase 13,14 . Mostrou-se também que o tratamento com fluconazol associado ao Lactobacillus rhamnosus e ao Lactobacillus reuteri, via oral, diminuiu, em quatro semanas, os sintomas relacionados à vulvovaginite por Candida albicans, além de diminuir o crescimento da levedura em cultura 4 .…”

Section: Discussionunclassified

Lactobacillus rhamnosus pode alterar a virulência de Candida albicans

Leão¹,

Silva²,

Santos³

et al. 2015

Rev. Bras. Ginecol. Obstet.

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ResumoOBJETIVO: Avaliar a influência de Lactobacillus rhamnosus na expressão dos fatores de virulência de Candida albicans in vitro. MÉTODOS: Uma suspensão de L. rhamnosus foi inicialmente cultivada em ágar MRS. No dia seguinte, foi adicionado ágar Sabouraud dextrose sobre o crescimento dos lactobacilos e C. albicans foi cultivada, por 24, 48 e 72 horas. As cepas de Candida foram então isoladas para investigação da capacidade de formação de biofilme, por meio do cultivo em placas de 96 poços e leitura das densidades ópticas e contagem de unidades formadoras de colônia por mL (UFC/mL). Também se investigou a capacidade de formação de tubo germinativo, após incubação em soro de cavalo e contagem em 200 células. Os resultados foram comparados aos observados nas cepas de Candida cultivadas na ausência de L. rhamnosus, utilizando o teste t de Student para análise estatística. RESULTADOS: Observou-se uma redução significativa no crescimento de C. albicans na presença de lactobacilos após 24, 48 ou 72 horas. Também foi observada redução significativa na formação de tubo germinativo após a interação por 48 ou 72 horas. Quanto à formação de biofilme, não foi observada diferença significante entre as cepas de Candida cultivadas na presença ou na ausência de lactobacilos. CONCLUSÃO: Os resultados sugerem que L. rhamnosus é capaz de influenciar significativamente o crescimento e a expressão de fatores de virulência de C. albicans in vitro, podendo interferir na patogenicidade desses micro-organismos. Abstract PURPOSE:To investigate the influence of Lactobacillus rhamnosus in the expression of virulence factors of Candida albicans in vitro. METHODS: A suspension of L. rhamnosus was initially grown in MRS agar. The other day, Sabouraud dextrose agar was added on the growth of lactobacilli and C. albicans was seeded for 24, 48 and 72 hours. Candida strains were then isolated for investigation of the ability of biofilm formation, by means of cultivation into 96 wells plaque, and reading the optical densities and counting colony forming units per mL. Also the ability of germ tube formation was investigated, after incubation in horse serum and counting of 200 cells. The results were compared to Candida strains grown in the absence of L. rhamnosus, using Student's t test for statistical analysis. RESULTS: there was a significant reduction in the growth of C. albicans in the presence of lactobacilli after 24, 48 or 72 hours. Significant reduction was also observed in germ tube formation after interaction for 48 or 72 hours. For biofilm formation, no statistically significant difference was observed between the Candida strains grown in the presence or absence of lactobacilli. CONCLUSION: The results suggest that L. rhamnosus is able to influence significantly the growth and expression of virulence factors of C. albicans in vitro, and may interfere with pathogenicity of these micro-organisms.

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Influence of probiotics on Candida presence and IgA anti-Candida in the oral cavity

Cited by 28 publications

References 5 publications

Effect of Probiotic Bacteria on Oral Candida in Frail Elderly

Effect of Probiotic Bacteria on Oral Candida in Frail Elderly

Lactobacillus acidophilus-derived biosurfactant effect on gtfB and gtfC expression level in Streptococcus mutans biofilm cells

Lactobacillus rhamnosus pode alterar a virulência de Candida albicans

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