Influence of Probiotic Supplementation on Climacteric Symptoms in Menopausal Women-a Mini Review

Abstract

Menopause (MP) is a natural physiological event of woman’s life and is defined as the absence of menstrual periods for at least twelve months and loss of function of ovarian. The common symptoms of MP are irregular vaginal bleeding, hot flushes especially in head and chest, night sweats, insomnia, vaginal and urinary symptoms, cognitive dysfunction, increased cancer risk, osteopenia, high blood pressure, diabetes, and cardiovascular diseases. Microbiome has been associated with several health benefits. Probiotic supplementation helps to enhance the quality of microbiome thereby confers the health benefits to the host system. The microbiome, hormone (estrogen) changes, and probiotic intervention are related to the health status of the female reproductive system. The vaginal microbiome (VM) play a critical role in female reproductive health and MP, which can be greatly influenced by probiotics, and other medicine especially antibiotics and hormone therapy. The role of VM in supporting vaginal health is not clear and debatable. Understanding the role of vaginal Lactobacillus could expose the pathogenesis of vaginal dysbiosis, which helps to improve diagnostic and therapeutic strategies for several dysbiosis associated health issues and menopause-related symptoms. Recent studies suggested that the intervention of probiotic preparation with or without nutraceutical formulation (mostly with isoflavones) improve the health status of menopausal women. The mechanism of probiotics mediated health improvement in menopausal women is not yet described clearly. Several controversies are there on the link between probiotic, gut microbiota, vaginal microbiota, and estrogen deficit. The present review summarizes the influence of probiotic supplementation on climacteric symptoms in menopausal women. The literature search was made in Scopus, Google Scholar, PubMed using the keywords “probiotics” and “menopause”. The documents were carefully checked for the relevance to the current manuscript, and the selection was made without any restriction in the year of publication.

The Role of Probiotics in Colorectal Cancer Management

“…Even though several advanced medical procedures (chemotherapy, surgery, immune and radiation therapy) are available for CRC treatment, the survival rates are poor with many adverse treatment-associated side effects, which affects the quality of the life [8]. Probiotics are a well-known bioactive candidate for the treatment of several diseases, and ill-health conditions [12][13][14][15][16][17][18]. e administration of probiotics in an adequate amount confers the health benefits to the host by positive regulation of the gut microbiota.…”

The Role of Microbiome, Dietary Supplements, and Probiotics in Autism Spectrum Disorder

“…Several studies proved that the probiotics (a group of live microbes that confers health benefits upon being consuming in an adequate amount) supplementation confers several health benefits by the positive amendment of gut microbiota [14][15][16][17]. The influence of probiotic intervention in ASD patients has also been reported and considered as an alternative and complementary therapeutic supplement for ASD [7,13].…”

The Effect of Lactobacillus acidophilus YT1 (MENOLACTO) on Improving Menopausal Symptoms: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial

“…Menopause occurs in most women between the ages of 45 and 55, although timing and symptoms can vary depending on the individual. Menopausal symptoms are increasingly recognized as having significant health implications through decreases in estrogen levels and lower estrogen exposure [1,2]. Major symptoms include vasomotor issues (hot flushes and/or night sweats), sleep disruption, vaginal symptoms (dryness and/or infections), depression and anxiety, cognitive changes (declines in memory and concentration), and sexual dysfunction [3,4].…”