Influence of pretreatment ideal body weight percentile and albumin on prognosis of nasopharyngeal carcinoma: Long-term outcomes of 512 patients from a single institution

Li, Guo; Gao, Jin; Liu, Zhi Gang; Tao, Yuan; Xu, Bing; Tu, Zi Wei; Zhang, Xiu Ping; Zeng, Mu‐Sheng; Xia, Yun

doi:10.1002/hed.23357

Cited by 61 publications

(54 citation statements)

References 44 publications

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“…42 Although PEG catheterization is more receptive than nasogastric tubes, studies [43][44][45] have also shown that PEG may result in a decrease in swallowing process. 50 In addition, we observed that overweight patients receiving HEN still had decreased HB at week 2 and leukocytopenia at week 4 of CCRT. 46 However, whether PEG could cause swallowing disorders remains controversial.…”

Section: Discussionmentioning

confidence: 65%

Home enteral nutrition may prevent myelosuppression of patients with nasopharyngeal carcinoma treated by concurrent chemoradiotherapy

Zhou

Chu

et al. 2019

Head & Neck

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Background The aim of this study is to assess the effect of home enteral nutrition (HEN) on the myelosuppression of patients with nasopharyngeal cancer (NPC) during the course of concurrent chemoradiotherapy (CCRT). Methods A total of 18 outpatients with NPC administered oral nutritional supplementation intervention at home during the course of CCRT were designated as the HEN group, whereas 36 patients with NPC who had previously completed CCRT were retrospectively included as the control group. Patient Generated Subjective Global Assessment, body mass index (BMI), and blood test were evaluated prior to CCRT. During the course of CCRT, blood test was assessed every 2 weeks. Results In male patients, hemoglobin (HB) and red blood cell were decreased (P < .05) in both HEN and control group after CCRT, whereas white blood cell (WBC) started to decrease since week 2 of CCRT in the control group but maintained in the HEN group which was significantly higher than the control (5.05 ± 1.29 vs 3.77 ± 1.5, P < .05). In female patients, HB and WBC were reduced in control group during CCRT, whereas these indicators also maintained in the HEN group. Surprisingly, all patients with lower BMI (<24 kg/m2) had a significant increase in platelet (PLT) after CCRT (200.78 ± 58.03 vs 253.00 ± 69.82, P < .05), while had steady HB and WBC values in the HEN group. At the end of CCRT, WBC and PLT of the HEN group were both higher than those in the control group (5.21 ± 1.07 vs 3.37 ± 1.52), (253.00 ± 69.82 vs 165.57 ± 59.56) (P < .05 for both). Our findings suggest that HEN is effective in preventing myelosuppression during CCRT for patients with NPC. Conclusion Our findings suggest that HEN is effective in preventing myelosuppression during CCRT for patients with NPC.

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Section: Discussionmentioning

confidence: 65%

Home enteral nutrition may prevent myelosuppression of patients with nasopharyngeal carcinoma treated by concurrent chemoradiotherapy

Zhou

Chu

et al. 2019

Head & Neck

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“…Full texts of these 16 remaining studies were assessed according to the inclusion and exclusion criteria, and 6 articles failed to offer sufficient prognostic information. Finally, as shown in Figure , a total of 10 studies comprising 7339 cases were included in this meta‐analysis . Patients were from different cancer centres and were assessed at different time points and differed in metastatic or non‐metastatic NPC.…”

Section: Resultsmentioning

confidence: 99%

“…Finally, as shown in Figure 1, a total of 10 studies comprising 7339 cases were included in this meta-analysis. 20,21,[25][26][27][28][29][30][31][32] Patients were from different cancer centres and were assessed at different time points and differed in metastatic or non-metastatic NPC.…”

Section: Search Resultsmentioning

confidence: 99%

“…However, owing to a paucity of data, the association between pre‐treatment serum ALB and the prognosis of NPC remains controversial. Some studies have indicated a close connection, but some studies have shown no significant association . For that reason, we conducted a meta‐analysis and systematic review of the prognostic significance of pre‐treatment serum ALB in NPC.…”

Section: Introductionmentioning

confidence: 99%

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Prognostic role of pre‐treatment serum albumin in patients with nasopharyngeal carcinoma: A meta‐analysis and systematic review

Yang

Wang

Liang

et al. 2019

Clinical Otolaryngology

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Background Pre‐treatment serum albumin (ALB) is a novel index that was identified in recent years and is considered to be closely related to the prognosis of nasopharyngeal carcinoma (NPC). However, the association between ALB and NPC remains controversial. Objective of Review To assess the prognostic significance of pre‐treatment serum ALB in patients with NPC. Type of Review A systematic review and meta‐analysis. Search Strategy We searched PubMed, the Cochrane Library and the Web of Science for studies published up to August 2018. The keywords used were related to albumin, nasopharyngeal carcinoma and prognosis. Evaluation Method We extracted the following data from all included studies: author, publication year, country, cancer centre, time points of randomisation, sample size, mean or median age, gender, TNM stage of NPC, cut‐off value of pre‐treatment serum albumin, number of high‐grade cases and duration of follow‐up. Then, we generated the pooled hazard ratios (HR) for overall survival (OS) and distant metastasis‐free survival (DMFS) to perform this meta‐analysis. Results Ten studies comprising 7339 cases were included. Lower pre‐treatment serum ALB levels were significantly associated with worse OS (HR = 1.32, 95% CI 1.17‐1.48) and DMFS (HR = 1.40, 95% CI 1.08‐1.80). In general, our findings were further verified in the subgroup analyses based on three features, including cancer stage, cut‐off value and analysis type. Conclusion A decreased level of pre‐treatment serum albumin implies a poor prognosis and can be detected to define the risk stratification of NPC patients.

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“…[11] Several clinical studies have shown that patients receiving nutritional intervention survive longer. [12,13] Poor nutritional practices, which can lead to under-nutrition, can contribute to the incidence and severity of treatment side effects and increase the risk of infection and mortality in cancer patients. [2] Advanced colorectal cancer patients, especially those with malnutrition, experience poor general health and cannot adapt to project implementation.…”

Section: Discussionmentioning

confidence: 99%

A multidisciplinary team approach for nutritional interventions conducted by specialist nurses in patients with advanced colorectal cancer undergoing chemotherapy

Lin

Chen

et al. 2017

Medicine

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Background & aims:Nutritional interventions for malnutrition in cancer patients can be helpful. However, concise intervention recommendations remain controversial. Thus, the aim of this study was to report on a nutrition intervention conducted by a multidisciplinary team of specialist nurses and to explore the effect of nutritional intervention on cancer patients.Methods:This prospective clinical trial study enrolled 110 colorectal cancer patients undergoing chemotherapy. The patients were evaluated upon admission using the 2002 Nutritional Risk Screening system (NRS-2002). The patients were randomly divided into intervention and control groups including 55 patients each. Patients in the control group were administered a normal diet, while those in the intervention group received individual recipes developed by a team of professional nurses, clinical doctors, dietitian, family caregivers, and the patients themselves. Patient weight and serum albumin and prealbumin levels were compared between the 2 groups at different time points.Results:There was a significant difference in patient weight and serum albumin and prealbumin levels before and after nutrition intervention in the intervention group (P < .05). In the control group, weight did not change during ordinary diet guidance. Serum albumin level was slightly improved after 12 cycles of chemotherapy, similar to the prealbumin results. There were statistically significant differences in serum albumin and prealbumin levels between the intervention and control groups after nutrition intervention (P < .05). However, there was no statistically significant difference in weight between the groups after nutrition intervention (P > .05).Conclusion:A multidisciplinary team approach for nutrition intervention conducted by specialist nurses improved prealbumin levels in colorectal cancer patients undergoing chemotherapy, with no weight change.

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Influence of pretreatment ideal body weight percentile and albumin on prognosis of nasopharyngeal carcinoma: Long-term outcomes of 512 patients from a single institution

Abstract: Decrease of pretreatment IBW% and albumin was related to poorer survival of NPC.

Cited by 61 publications

References 44 publications

Home enteral nutrition may prevent myelosuppression of patients with nasopharyngeal carcinoma treated by concurrent chemoradiotherapy

Home enteral nutrition may prevent myelosuppression of patients with nasopharyngeal carcinoma treated by concurrent chemoradiotherapy

Prognostic role of pre‐treatment serum albumin in patients with nasopharyngeal carcinoma: A meta‐analysis and systematic review

A multidisciplinary team approach for nutritional interventions conducted by specialist nurses in patients with advanced colorectal cancer undergoing chemotherapy

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