Influence of preservation solution on early lung function (Euro-Collins vs Perfadex)

HLA mismatches influence lung transplant recipient survival, bronchiolitis obliterans and rejection: Implications for donor lung allocation

“…First, improved preservation since the introduction of low-potassium dextran lung preservation solution may be responsible for decreased clinical and subclinical reperfusion injury, 11,12 factors that have been associated with long-term risk for the development of BO and mortality. 21 Refinements in immunosuppressive regimens may also be responsible for decreased variability in outcomes after lung transplantation.…”

Report of the ISHLT Working Group on Primary Lung Graft Dysfunction Part III: Donor-Related Risk Factors and Markers

“…[65][66][67][68][69][70] Five centers showed significantly better lung function on arrival in the ICU and a trend toward lower 30-day mortality with…”

Transplantation of the uterus in the sheep: oxidative stress and reperfusion injury after short-time cold storage

“…Low-molecular weight dextran also has an antiinflammatory effect, from protection of endothelium and reduction of complement activation (12,13), and it therefore is suitable for use in preservation solutions. Perfadex is designed mainly for the storage of lung transplants (14,15) but has also proven to be efficient in preserving contractility of rat vascular smooth muscle (16) and porcine pancreatic function (17) after extended cold ischemia. In the study on cold storage of human myometrium that was mentioned in the previous paragraph, electron microscopy indicated that Perfadex demonstrated preservation of contractile ability and of concentration of adenosine triphosphate, as well as of cellular ultrastructure, after 24 hours of cold storage without reperfusion (11).…”