Influence of pregnancy on the course of Hodgkin’s disease

Barry, Richard M.; Diamond, Henry D.; Graver, Lloyd

doi:10.1016/s0002-9378(16)35688-5

Cited by 74 publications

(16 citation statements)

References 15 publications

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“…In fact, as reported in the literature, probably tumor progression during pregnancy is less rapid than during postpartum [10,11]. As for the children, it is very important to monitor these children for a long period to evaluate the long-term effects of chemotherapy on their physi-cal growth, intellectual and neurological functions, gonadal function, reproductive capacity, and transplacental carcinogenesis [9].…”

Section: Discussionmentioning

confidence: 99%

Hodgkin’s Disease during Pregnancy: Diagnostic and Therapeutic Management

Anselmo¹,

Cavalieri²,

Enrici³

et al. 1999

Fetal Diagn Ther

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Objectives: To evaluate the possibility that women affected by Hodgkin’s disease (HD) during their second or third trimester of pregnancy can safely carry their pregnancy to term. Methods: From 1986 to 1997, 6 women came to our Center during the second trimester of pregnancy and were diagnosed as having HD. Three of these 6 patients were treated with chemotherapy before delivery and 3 of them were kept under observation and started treatment after delivery. Results: All 6 women gave birth to a healthy female. Conclusions: The pregnancy does not worsen the course of the illness and does not compromise long-term clinical remission and recovery.

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Section: Discussionmentioning

confidence: 99%

Hodgkin’s Disease during Pregnancy: Diagnostic and Therapeutic Management

Anselmo¹,

Cavalieri²,

Enrici³

et al. 1999

Fetal Diagn Ther

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“…First, some of the frequently references studies were performed decades ago (Stewart & Monto, 1952;Barry et al, 1962;Kadson, 1949;Bichel, 1950;Myles, 1955). Since the diagnostic tools, staging methods, and especially treatment modalities have progressed tremendously in recent years, it is difficult to extrapolate these results to the present time.…”

Section: Discussionmentioning

confidence: 99%

“…Since the diagnostic tools, staging methods, and especially treatment modalities have progressed tremendously in recent years, it is difficult to extrapolate these results to the present time. Second, most studies do not compare matched controls but rather compare pregnant women with a nonmatched cohort of nonpregnant women with HD (Barry et al, 1962;Gobbi et al, 1984). Such reports carry a substantial risk of bias since the groups compared may be unbalanced for significant prognostic factors and thus the analysis may be misleading.…”

Section: Discussionmentioning

confidence: 99%

“…Early studies reported a higher frequency of relapse and lower survival rates in HD patients who were pregnant (Southman et al, 1956). Later publications rejected this conclusion, claiming that pregnancy neither exacerbates the disease nor adversely affects survival (Stewart & Monto, 1952;Riva et al, 1953;Barry et al, 1962;Gobbi et al, 1984;Tawil et al, 1984;Nisce et al, 1986). The view that pregnancy does not affect the course of Hodgkin's disease and the disease does not affect the course of pregnancy has become widely accepted and repeatedly stressed in reviews and textbooks (Ward & Weiss, 1989;Sutcliffe & Chapman, 1985;Becker, 1968).…”

mentioning

confidence: 99%

“…The view that pregnancy does not affect the course of Hodgkin's disease and the disease does not affect the course of pregnancy has become widely accepted and repeatedly stressed in reviews and textbooks (Ward & Weiss, 1989;Sutcliffe & Chapman, 1985;Becker, 1968). However, this conclusion is based on single cases or a surprisingly small number of uncontrolled studies (Barry et al, 1962;Gobbi et al, 1984;Tawil et al, 1984;Nisce et al, 1986).…”

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confidence: 99%

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Maternal and foetal outcome following Hodgkin's disease in pregnancy

Lishner

Zemlickis²,

Degendorfer³

et al. 1992

Br J Cancer

130

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Summary The peak incidence of Hodgkin's disease occurs during the reproductive age, and its association with pregnancy is at a rate of between 1:1,000 -1:6,000. We studied the effects of Hodgkin's Disease on the course and survival of 48 women who had Hodgkin's Disease and who were pregnant, and compared their outcome with non-pregnant matched women who were of similar stage of disease, age at diagnosis, and calenderic year of treatment. Twenty-year survival of pregnant women with Hodgkin's Disease was not different from that of their matched controls. Pregnant women with Hodgkin's Disease had similar distribution of stages to the controls.

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