Management of Cancer During Pregnancy

Primary Central Nervous System Lymphoma (PCNSL) occurring in pregnancy

“…For some patients, treatment delay may not adversely affect the maternal prognosis [7,8]. However, for patients with significant neurological deficits, it would be imperative to deliver the child early to facilitate initiation of lymphoma therapy.…”

Esophageal Carcinoma in Pregnancy

“…Although teratogenicity and fetal toxicity have been reported, a causative link has not been established [5]. Doll had reported fetal malformation in 17 and 25 % of pregnancies exposed to single and combined chemotherapy, respectively, during the first trimester, whereas there was no risk of increased teratogenicity in the latter two trimesters [6]. Taxanes and platins may be used in pregnancy after judging risk-benefit ratio.…”

Recommandations pour la prise en charge du cancer de l’ovaire pendant la grossesse

“…Durant les deuxième et troisième trimestres, il n'est plus observé d'augmentation du nombre de malformations [94][95][96][97][98] mais il peut se produire un retard de la croissance foetale et du développement psychomoteur décelable tardivement.…”

“…L'incidence se situe entre 7 et 17 % de malformations foetales après utilisation d'antinéoplasiques pendant le premier trimestre [94,96,98]. Il faut donc éviter une chimiothérapie avant 15 SA.…”