Influence of post-transplant mucosal-associated invariant T cell recovery on the development of acute graft-versus-host disease in allogeneic bone marrow transplantation

Kawaguchi, Koji; Umeda, Katsutsugu; Hiejima, Eitaro; Iwai, Atsushi; Mikami, Masamitsu; Nodomi, Seishiro; Saida, Satoshi; Kato, Ikunoshin; Hiramatsu, Hidefumi; Yasumi, Takahiro; Nishikomori, Ryuta; Kondo, Tadakazu; Heike, Toshio; Adachi, Souichi

doi:10.1007/s12185-018-2442-2

Cited by 43 publications

(42 citation statements)

References 30 publications

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“…High frequencies of tumour-infiltrating MAIT cells are associated with poor clinical outcomes for patients with HCC. In contrast, in the context of haematological malignancies, a higher frequency of MAIT cells after allogeneic haematopoietic cell transplantation is associated with less graft-versus-host disease (GVHD) 140,141 . Mouse studies have also shown a beneficial role of MAIT cells against GVHD and highlighted their role in maintaining gut integrity 142 .…”

Section: Mait Cells In Human Cancersmentioning

confidence: 99%

Mucosal-associated invariant T cells and disease

et al. 2019

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Mucosal-associated invariant T (MAIT) cells are unique innate-like T cells that bridge innate and adaptive immunity. They are activated by conserved bacterial ligands derived from vitamin B biosynthesis and have important roles in defence against bacterial and viral infections. However, they can also have various deleterious and protective functions in autoimmune, inflammatory and metabolic diseases. MAIT cell involvement in a large spectrum of pathological conditions makes them attractive targets for potential therapeutic approaches.

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Section: Mait Cells In Human Cancersmentioning

confidence: 99%

Mucosal-associated invariant T cells and disease

et al. 2019

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“…In the allo-HCT setting, no associations between high MAIT cell numbers and protection from infections have been reported so far [93]. However, low frequencies of MAIT cells in the graft and post-HCT are associated with severe GvHD [74,[92][93][94][95], and higher numbers seem to be associated with improved overall survival [94].…”

Section: Mait Cellsmentioning

confidence: 99%

“…Reconstitution of MAIT cells post-HCT significantly correlates with age [92,94] and cell source [92,93,96,97]. Early MAIT cell reconstitution is driven by the HPE of the MAIT cells transferred with the graft [93].…”

Section: Mait Cellsmentioning

confidence: 99%

Reconstitution of T Cell Subsets Following Allogeneic Hematopoietic Cell Transplantation

Dekker

Koning

Lindemans

et al. 2020

Cancers

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Allogeneic (allo) hematopoietic cell transplantation (HCT) is the only curative treatment option for patients suffering from chemotherapy-refractory or relapsed hematological malignancies. The occurrence of morbidity and mortality after allo-HCT is still high. This is partly correlated with the immunological recovery of the T cell subsets, of which the dynamics and relations to complications are still poorly understood. Detailed information on T cell subset recovery is crucial to provide tools for better prediction and modulation of adverse events. Here, we review the current knowledge regarding CD4+ and CD8+ T cells, γδ T cells, iNKT cells, Treg cells, MAIT cells and naive and memory T cell reconstitution, as well as their relations to outcome, considering different cell sources and immunosuppressive therapies. We conclude that the T cell subsets reconstitute in different ways and are associated with distinct adverse and beneficial events; however, adequate reconstitution of all the subsets is associated with better overall survival. Although the exact mechanisms involved in the reconstitution of each T cell subset and their associations with allo-HCT outcome need to be further elucidated, the data and suggestions presented here point towards the development of individualized approaches to improve their reconstitution. This includes the modulation of immunotherapeutic interventions based on more detailed immune monitoring, aiming to improve overall survival changes.

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“…pDCs are known to promote tolerance via Treg expansion, 19 whereas MAIT cells enhance gastrointestinal tract barrier function and microbiome diversity and inhibit alloantigen presentation after SCT. 20,21 To our knowledge, neither population has been linked to GVL effects previously. It is possible that temporal modulation of these innate cell populations can modify leukemia and alloantigen presentation in a way that favors GVL over GVHD.…”

Section: Discussionmentioning

confidence: 89%