Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis

He, Qiaojun; Mam-Lam-Fook, Célia; Chaignaud, Julie; Danset-Alexandre, Charlotte; Iftimovici, Anton; Hauguel, Johanna Gradels; Houle, Gabrielle; Liao, Calwing; Rouleau, Guy A.; Kébir, Oussama; Krebs, Marie‐Odile; Chaumette, Boris

doi:10.1038/s41398-021-01624-z

Cited by 21 publications

(16 citation statements)

References 45 publications

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“…The literature shows that the GPSs of cognitive performance and educational attainment are significantly associated with general intelligence 14, 15 and brain development 14, 16 . In addition, the GPSs of schizophrenia and ADHD successfully predicted psychiatric disorders 17–19 . However, the combined causal effects of genes and the neighborhood environment during development in children remain unclear.…”

Section: Introductionmentioning

confidence: 94%

Gene-Environment Pathways to Cognitive Intelligence and Psychotic-Like Experiences in Children

Park

Lee

Cho³

et al. 2021

Preprint

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Identifying the social and biological mechanisms of cognitive and psychological development of children is essential for optimizing preventive and educational efforts. However, the causal pathways by which genetic and environmental factors affect cognitive and psychiatric outcomes remain unknown, especially in early childhood. We examined the causal relationships among genes, the environment, intelligence, and psychotic-like experiences in 7,632 multiethnic (5,905 with European ancestry) children aged 9-10 years old from the Adolescent Brain Cognitive Development (ABCD) Study. Using up-to-date computational causal analysis and rigorous path modeling, we found a significant causal influence of residential, family, and school environments and genome-wide polygenic scores of cognitive capacities on preadolescents' psychotic-like experiences mediated by intelligence. Mitigation of good parenting behavior and positive school environments on psychotic-like experiences dominated the pernicious effects of genetic and residential adversities. Our findings support that intelligence may be a biological resilience factor for psychosis. To the best of our knowledge, this is the first study to identify casual trajectories of neurocognitive development in early childhood and the first to provide empirical evidence that positive parenting behavior and school environment can impose a considerable degree of causal impact on children's cognitive and psychiatric outcomes. We suggest the implementation of socioeconomic policies to improve family and school environments and promote local economic development to enhance children's cognitive ability and mental health.

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Section: Introductionmentioning

confidence: 94%

Gene-Environment Pathways to Cognitive Intelligence and Psychotic-Like Experiences in Children

Park

Lee

Cho³

et al. 2021

Preprint

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“…A systematic review by Ribeiro-Santos, Teixeira and Vinicius [ 45 ] found that MCP-1 and IL-18 levels were associated with cognitive impairments in schizophrenia. In addition, Lim et al [ 32 ], Perkins et al [ 46 ], and He et al [ 47 ] reported PRS as a potential biomarker for early cognitive deficits or for the transition from the ultra-high-risk state to established psychosis.…”

Section: Discussionmentioning

confidence: 99%

Is it possible to stage schizophrenia? A systematic review

et al. 2022

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Introduction A staging model is a clinical tool used to define the development of a disease over time. In schizophrenia, authors have proposed different theoretical staging models of increasing complexity. Therefore, the aims of our study were to provide an updated and critical view of the proposed clinical staging models for schizophrenia and to review the empirical data that support them. Methods Systematic literature review following PRISMA guidelines. From the PubMed database and backward reference search, a total of 141 records were retrieved, but only 20 were selected according to the inclusion criteria: (a) available in English; (b) participants with schizophrenia ≥ 18 years; and (c) theoretical and empirical research studies intended to develop, validate, and/or improve staging models of schizophrenia. Results Different clinical staging models for schizophrenia were identified, information about the proposed stages was tabulated and presented in the Results section (Tables 1, 2). Most of which include neuroimaging, functioning, and psychopathology, but only two models add objective biomarkers and none include patient point of view. However, few models have been psychometrically tested or used small samples and thus have been validated only partially. In addition, five studies proposed therapeutic interventions according to the stage of the disorder from a theoretical point of view. Discussion In conclusion, it is possible to stage schizophrenia, but the models developed have several limitations. Empirical validation and inclusion of more specific biomarkers and measures of other life areas affected by schizophrenia could help in the development of more valid models.

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“…Self-efficacy 16 is an overall relatively stable sense of competence or self-confidence that individuals show in coping with challenges in various environments. Zhou 46 indicated that self-efficacy and motivation may act as mediators in the relationship between neurocognition and self-management in schizophrenia.…”

Section: Discussionmentioning

confidence: 99%

“…14 Abroad, Gooding PA 15 proposed improving resilience, which could allow patients to resist negative ideas and impulses, such as self-injury or suicide, and highlighted external factors that supported resilience, including social support, reciprocity and religious coping. He 16 suggested that cognitive performance and a high level of resilience are positively correlated and that improving resilience can improve cognitive function. Cognitive impairment is a core feature of schizophrenia.…”

Section: Introductionmentioning

confidence: 99%

Mediating Effect of Self-Efficacy on the Relationship Between Perceived Social Support and Resilience in Patients with Recurrent Schizophrenia in China

Wang¹,

Li²,

Xiao-jian³

et al. 2022

NDT

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Purpose To explore the mediating effect of self-efficacy on the relationship between perceived social support and resilience in patients with recurrent schizophrenia in China. Patients and Methods In this cross-sectional study, a total of 176 patients with recurrent schizophrenia who were hospitalized in a tertiary hospital in Hunan Province, China, completed a general data questionnaire, the Connor Davidson Resilience Scale (CD-RISC), the Perceived Social Support Scale (PSSS) and the General Self-Efficacy Energy Scale (GSES). Results Among the 176 patients, the mean GSES score was 2.02±0.61, the mean PSSS score was 56.77±14.61, and the mean CD-RISC score was 58.06±17.26. Self-efficacy played a partial mediating role between social support and resilience, and the mediating effect accounted for 42.56% of the total effect. Conclusion The resilience level of patients with recurrent schizophrenia in China is moderate and needs to be improved. This research revealed that self-efficacy played a part in mediating perceived social support and resilience in patients with recurrent schizophrenia in China. Perceived social support can indirectly affect resilience in patients with recurrent schizophrenia through self-efficacy. Comprehensive interventions in perceived social support and self-efficacy would help to improve the resilience of patients with recurrent schizophrenia.

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Influence of polygenic risk scores for schizophrenia and resilience on the cognition of individuals at-risk for psychosis

Cited by 21 publications

References 45 publications

Gene-Environment Pathways to Cognitive Intelligence and Psychotic-Like Experiences in Children

Gene-Environment Pathways to Cognitive Intelligence and Psychotic-Like Experiences in Children

Is it possible to stage schizophrenia? A systematic review

Mediating Effect of Self-Efficacy on the Relationship Between Perceived Social Support and Resilience in Patients with Recurrent Schizophrenia in China

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