Influence of Plasma Treatments on the Hemocompatibility of PET and PET + TiO2 Films

Abstract

A dielectric barrier discharge (DBD) in helium was used to ameliorate the interface between the blood and the surface of polymeric implants: polyethylene terephthalate (PET) and PET with titanium oxide (PET + TiO 2 ).A higher crystallinity degree was found for the DBD treated samples. The wettability of polymers was improved after the treatment. The chemical composition, analyzed by infrared spectroscopy was preserved during the DBD treatment. The surface modifications have been correlated with polymers hemocompatibility. Concerning the polymer surface-blood interaction, the treatment induced a decrease of the interfacial tension between the blood components and the treated surfaces. The in vitro tests of hemocompatibility showed no perturbation in the blood composition when the polymer samples are present in the blood volume. An interesting result is related to the whole blood clotting time that shows a dramatic increase on the treated surfaces. Moreover, the coagulation kinetics on the treated surfaces is modified.

In vitroCyto and Blood Compatibility of Titanium Containing Diamond-Like Carbon Prepared by Hybrid Sputtering Method

“…Similarly, the contact angle measurements were carried out with respect to glycerol. The values of polar and dispersive components of the testing liquids are given in Table 2 [22] . The total surface energy (γ SV ) of the Ti-DLC films was calculated using the geometric mean approach for adhesion work (W A ):…”

“…The interfacial tension (γ SL ) between the solid surface and biological fluids (fibrinogen, immunoglobulin G and albumin) was calculated using the following expression [22] :…”

“…The energetic characteristics (polar and dispersive components of the surface energy) of the biological liquids are shown in Table 3 [22] . The chemical composition of the DLC film surface and chemical binding state were examined by using X-ray photoelectron spectroscopy (SSX-100 Electron spectrometer from SHIMADZU).…”

Loading and Release of Drugs from Oxygen‐rich Plasma Polymer Coatings

“…For example, loading antimicrobial drugs into the responsive surfaces may be an efficient way to prevent biofilm formation on polymers,33, 34 thereby, avoiding infections associated with the use of medical devices, particularly catheters 35. Poly(ethylene terephthalate; PET) is widely used in meshes, sutures, vascular prostheses and in composites with inorganic materials, used in orthopedic implants; however, these can readily become colonized with bacteria 36, 37. Plasma treatments and photo‐polymerized coatings have been reported in attempts to prevent bacterial adhesion;38 more recently, PP coatings have been prepared that contain embedded silver nanoparticles or polymerizable ciprofloxacin derivatives, which undergo hydrolysis and thereby release the drug or Ag + ions into the physiological medium 39, 40.…”

In situ synthesis of hybrid nanocomposite with highly order arranged amorphous metallic copper nanoparticle in poly(2-hydroxyethyl methacrylate) and its potential for blood-contact uses

“…The development of new biomaterials with improved blood compatibility has continuously attracted much attention. Recently, thromboresistant materials based on inorganic compounds, metals and metallo-organic compounds have received the most attention, as they have been shown to provide more advantages over conventional polymeric materials which are not truly thrombosis-free surface but are currently widely available on the market [7][8][9]. For instance, n-type oxides, which behave as semiconductors, provide a thromboresistant surface [10].…”