Influence of perfluorocarbons on Carbamazepine and Benzodiazepine for a neuro-lung protective strategy

Natchimuthu, V.; Thomas, Sabu; Ramalingam, Murugan; Ravi, Satyam

doi:10.1016/j.jocn.2017.04.019

Cited by 3 publications

(2 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An in-depth review of the scientific literature up to 2015 shown an active interest in PFD for myriad medical, biochemical, and chemical engineering side: blood substitute [20][21][22][23][24], liquid fluorocarbon lavage of airways [25][26][27], transplantology [28,29], extracorporeal life support [30], cryosurgery and tissue engineering [31][32][33][34], tattoos treatment [32,[35][36][37][38][39][40][41][42][43][44], ophthalmology [45][46][47][48][49][50][51][52][53][54][55], drug production [56][57][58][59][60], headspace-gas chromatography-tandem [61] and electrospray ionization [62] mass spectrometry, magnetic resonance imaging oximetry [63], cell and microbial culturing [64][65]…”

Section: Introductionmentioning

confidence: 99%

Separation of an Industrial Mixture of Decalin or Naphthalene Fluorination Products: Cis-Perfluorodecalin, Trans-Perfluorodecalin and Perfluoro(butylcyclohexane): Physicochemical, Thermophysical, and Spectral Data

Lupachev,

Voshkin,

Kisel’

et al. 2023

Processes

View full text Add to dashboard Cite

New physicochemical data for trans-perfluorodecalin (trans-PDF) and cis-perfluorodecalin (cis-PFD) are presented. Based on the differential scanning calorimetry, the temperature and heat of the solid−liquid phase transition are determined. The coefficients of Antoine’s equation are calculated based on the experimental temperature–pressure dependence data. This article also presents data on the rheological properties («zero» shear viscosity and apparent activation energy for the viscous flow) of the studied compounds. The dependencies of refractive index and excess volume (density) on temperature are studied. Gas chromatography–mass spectrometry data and FTIR, 13C NMR, and 19F NMR spectra are provided. The dependencies are given for the perfluoro(butylcyclohexane) (BCH)–trans-PFD, BCH–cis-PFD, and trans-PFD–cis-PFD binary systems and BCH–trans-PFD–cis-PFD ternary system: refractive index and density (liquid molar volume and excess molar volume) of composition and temperature. The dependences of the excess molar volume on the composition and temperature of the mixtures are correlated with Redlich-Kister and Kohler equations.

show abstract

Section: Introductionmentioning

confidence: 99%

Separation of an Industrial Mixture of Decalin or Naphthalene Fluorination Products: Cis-Perfluorodecalin, Trans-Perfluorodecalin and Perfluoro(butylcyclohexane): Physicochemical, Thermophysical, and Spectral Data

Lupachev,

Voshkin,

Kisel’

et al. 2023

Processes

View full text Add to dashboard Cite

show abstract

“…It is quite difficult to break any of its bonds and to make it reactive with either CBZ or BDZ. Though the neutral structure of PFD is not so conducive for a perfect chemical reaction, the basic reason for choosing C 10 F 18 is due to the fact that it is an excellent oxygen carrier [17,18] . Chemically it is highly electronegative.…”

mentioning

confidence: 99%

Improved Performance of Carbamazepine and Benzodiazepine by Oxygen Enrichment through Perfluorodecalin for Lennox-Gastaut Type of Seizures

Natchimuthu¹,

Ravi²,

Amorós³

2021

ijps

Self Cite

View full text Add to dashboard Cite

Natchimuthu et al.: Oxygen Enrichment through PerfluorodecalinLennox-Gastaut syndrome is commonly characterized by a triad of features including multiple seizure types, intellectual disability or regression. The long-term prognosis for Lennox-Gastaut syndrome is generally poor due to uncontrolled seizures. Lennox-Gastaut syndrome type of seizures is epilepsy which is due to abnormal vibrations occurring in seizures. During the time of such abnormal vibrations, both the seizures and the lungs suffer a lack in oxygen content to a considerable extent. This results in prolonged vibrations and loses of nervous control. As a neuro-lung protective strategy, a novel attempt has been made to enrich both seizures and lungs with oxygen content through the support of perfluorodecalin (an excellent oxygen carrier) C 10 F 18 along with an enhancement in the antiepileptic activity by the two chosen antiepileptic drugs carbamazepine and benzodiazepine. The ultraviolet-visible spectrophotometer, fluorescence spectrograph, ultrasonic laser diffraction and scanning electron microscope studies reveals the co-existence of fluorine and drug in the emulsion produced by the sonication of both perfluorodecalin and the drug together. The presence of adequate fluorine and carbon play a catalytic role in ensuring the oxygen content and the antiepileptic activity of drug components.

show abstract

Design, Synthesis and in vitro Cytotoxicity Evaluation of New Fluorinated Ionic Salt (S)-(+)-2,3-Dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione as Strategies for Improving Anticonvulsant Activity

Natchimuthu¹,

Ravi

Ramalingam

et al. 2020

Asian J. Chem.

View full text Add to dashboard Cite

The reaction of (S)-(+)-2,3-dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione (1) with 4-(trifluoromethyl)benzoic acid (2, C8H5F3O2) in dimethylformamide leads to the formation of C8H5F3O2 (1) as a classical ionic salt 3. The structure of new compound has been characterized by FTIR, 1H NMR, 13C NMR, HRMS spectroscopy. The new compound was tested for in vitro cytotoxicity evaluation by MTT assay against breast adenocarcinoma cell line of MCF-7 cells. A new compound 3 (IC50:199 μM) emerged as minimal toxic when compared to clinical drugs carbamazepine, topiramate and benzodiazepine. A preliminary study of structure activity relationship revealed that the incorporation of fluoro or trifluoromethyl moiety into the compound, even through ionic bond formation, had a great effect on the biological activity and with less toxicity or side effects.

show abstract

Influence of perfluorocarbons on Carbamazepine and Benzodiazepine for a neuro-lung protective strategy

Cited by 3 publications

References 44 publications

Separation of an Industrial Mixture of Decalin or Naphthalene Fluorination Products: Cis-Perfluorodecalin, Trans-Perfluorodecalin and Perfluoro(butylcyclohexane): Physicochemical, Thermophysical, and Spectral Data

Separation of an Industrial Mixture of Decalin or Naphthalene Fluorination Products: Cis-Perfluorodecalin, Trans-Perfluorodecalin and Perfluoro(butylcyclohexane): Physicochemical, Thermophysical, and Spectral Data

Improved Performance of Carbamazepine and Benzodiazepine by Oxygen Enrichment through Perfluorodecalin for Lennox-Gastaut Type of Seizures

Design, Synthesis and in vitro Cytotoxicity Evaluation of New Fluorinated Ionic Salt (S)-(+)-2,3-Dihydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine-5,11(10H,11aH)-dione as Strategies for Improving Anticonvulsant Activity

Contact Info

Product

Resources

About