Improved Performance of Carbamazepine and Benzodiazepine by Oxygen Enrichment through Perfluorodecalin for Lennox-Gastaut Type of Seizures

Abstract

Natchimuthu et al.: Oxygen Enrichment through PerfluorodecalinLennox-Gastaut syndrome is commonly characterized by a triad of features including multiple seizure types, intellectual disability or regression. The long-term prognosis for Lennox-Gastaut syndrome is generally poor due to uncontrolled seizures. Lennox-Gastaut syndrome type of seizures is epilepsy which is due to abnormal vibrations occurring in seizures. During the time of such abnormal vibrations, both the seizures and the lungs suffer a lack in oxygen content to a considerable extent. This results in prolonged vibrations and loses of nervous control. As a neuro-lung protective strategy, a novel attempt has been made to enrich both seizures and lungs with oxygen content through the support of perfluorodecalin (an excellent oxygen carrier) C 10 F 18 along with an enhancement in the antiepileptic activity by the two chosen antiepileptic drugs carbamazepine and benzodiazepine. The ultraviolet-visible spectrophotometer, fluorescence spectrograph, ultrasonic laser diffraction and scanning electron microscope studies reveals the co-existence of fluorine and drug in the emulsion produced by the sonication of both perfluorodecalin and the drug together. The presence of adequate fluorine and carbon play a catalytic role in ensuring the oxygen content and the antiepileptic activity of drug components.