Influence of pentavalent dopant addition to polarization and bioactivity of hydroxyapatite

Dhal, Jharana; Bose, Susmita; Bandyopadhyay, Amit

doi:10.1016/j.msec.2013.03.043

Cited by 22 publications

(9 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…20 The characteristic diffraction peaks for Ca 3 (PO 4 ) 2 (β-TCP) are observed in HA_Ta1100 composites in both atmospheres, which indicates that the presence of Ta accelerated the decomposition of HA. A similar finding that Ta made HA phase more unstable was reported by Dhal et al 21 The formation of Ca m Ta 2n O m+5n reduces the ratio of Ca/P of HA, which contributes to the formation of TCP due to a lower Ca/P ratio for TCP. For HA_Ta1100 and HA_Ta1200 composites, HA and β-TCP peaks are observed in both atmospheres.…”

Section: → + +supporting

confidence: 82%

“…However, after 5 days of incubation, cell proliferation is statistically significantly higher on HA_Ta1100 composites sintered in Ar compared to those sintered in air. Previously, it had been reported that the hydrophilic surface supports better cell adhesion and spread. , Hence, the current results show that cell adhesion was enhanced on a more hydrophilic surface for HA_Ta1100 composites sintered in Ar.…”

Section: Resultssupporting

confidence: 55%

“…Previously, it had been reported that the hydrophilic surface supports better cell adhesion and spread. 21,28 Hence, the current results show that cell adhesion was enhanced on a more hydrophilic surface for HA_Ta1100 composites sintered in Ar.…”

Section: → + +mentioning

confidence: 51%

See 2 more Smart Citations

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Cai

Wang

et al. 2021

ACS Omega

View full text Add to dashboard Cite

The effect of sintering atmosphere (air and Ar) and temperature (1100, 1200, 1300 °C) on the microstructure, mechanical properties, and bioactivity of hydroxyapatite/tantalum (HA/Ta) composites were systematically investigated by pressureless sintering of the mixture of HA and Ta powders. It shows that the sintering atmosphere greatly impacts the phase composition and microstructure of the HA/Ta composites. The higher diffusion of atoms promotes shrinkage and causes deeper reaction fusion between the HA matrix and Ta, which improved the interfacial binding of the HA/Ta composites. The refined grain structure and improved interfacial binding obtained within the Ar atmosphere compared to the air atmosphere benefit the mechanical properties. The maximum bending strength and shrinkage observed for the composites sintered at 1300 °C in the Ar atmosphere are 27.24 MPa and 6.65%, respectively. The cell counting kit-8 (CCK-8) method was used to investigate the in vitro cytocompatibility of HA/Ta composites. The results revealed that the HA/Ta composites sintered with different conditions have no cytotoxicity. The simulated body fluid (SBF) soaking results showed that all of the studied composites possess desirable bioactivity, as demonstrated by their ability to form calcium-deficient carbonate apatite layer on the surfaces. For composites sintered at 1300 °C, the surface apatite layer coverage of the composites obtained in the Ar atmosphere was increased by 139.7% than the ones obtained in air, which confirmed an enhanced bioactive mineralization ability. The results indicated that the HA/Ta composites sintered at 1300 °C in Ar possess desirable mechanical properties and bioactivity. This work opens up the new possibility for preparing HA-based composites and is of great value in biomedical applications.

show abstract

Section: → + +supporting

confidence: 82%

Section: Resultssupporting

confidence: 55%

See 1 more Smart Citation

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Cai

Wang

et al. 2021

ACS Omega

View full text Add to dashboard Cite

show abstract

“…The phase concentrations (PC) of 85.80%, 12.16%, and 2.04% for the Fe 2 MgTi 3 O 10 , CaTiO 3 , and Fe 3 O 4 phases, respectively, of the 1050°C sintered material (is illustrated in Table ) were calculated from the relative peak area of crystalline planes according to a novel approach using the Equation . The main advantages of this method over the relative intensity method are: (i) there is no need of any standard reference material in relative peak area method for comparison, (ii) it is independent of amount of sample used which, some time, can change intensity counts during XRD test, and (iii) thus accuracy and repeatability would be better. The crystallite size ( t ) (i.e., calculated by modified Debye‐Scherrer Equation S1) for the developed nanocomposite sintered at 850°C is depicted in Table .…”

Section: Resultsmentioning

confidence: 99%

Dielectric and AC conductivity studies of novel porous armalcolite nanocomposite‐based humidity sensor

et al. 2017

View full text Add to dashboard Cite

Armalcolite, a current motivated rare earth ceramic usually available in the moon, had been used for the first time, as dielectric-type humidity sensors. The armalcolite nanocomposite was prepared using multistep solid-state sintering under high pressure and a high-sensitive dielectric sensor was developed for humidity controlling applications. Different concerning phases developed by the proper sintering were analyzed precisely by X-ray diffraction (XRD) as well as scanning electron microscopy (SEM). At 100 Hz frequency, the obtained dielectric constant was 24 times greater at 95% relative humidity (RH) as compared to 33% RH. The armalcolite-based sensor showed lower hysteresis (<3.5%), good stability, and faster response (~18 seconds) and recovery (~35 seconds) times compared to conventional humidity sensors.The sensing mechanism of the nanocomposite was categorically determined by the analyzed characteristics parameters such as dielectric constants, normalized loss tangent, and alternating current conductivity properties. This study also confirmed that the whole conduction mechanism was accomplished by electrons or ions and dipoles in the entire RH range. Therefore, the present armalcolite-based porous nanocomposite would be a potential sensing material for novel humidity sensors.

show abstract

“…Tantalum (Ta) doping of HA was rarely explored [324,325]. Ta-HA was shown to increase human osteoblast cell proliferation, hinder charge storage ability, but at the same time induce the partial decomposition of HA into β- and α-tricalcium phosphate [324].…”

Section: Cation-substituted Hydroxyapatitesmentioning

confidence: 99%

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

et al. 2018

View full text Add to dashboard Cite

High-performance bioceramics are required for preventing failure and prolonging the life-time of bone grafting scaffolds and osseous implants. The proper identification and development of materials with extended functionalities addressing socio-economic needs and health problems constitute important and critical steps at the heart of clinical research. Recent findings in the realm of ion-substituted hydroxyapatite (HA) could pave the road towards significant developments in biomedicine, with an emphasis on a new generation of orthopaedic and dentistry applications, since such bioceramics are able to mimic the structural, compositional and mechanical properties of the bone mineral phase. In fact, the fascinating ability of the HA crystalline lattice to allow for the substitution of calcium ions with a plethora of cationic species has been widely explored in the recent period, with consequent modifications of its physical and chemical features, as well as its functional mechanical and in vitro and in vivo biological performance. A comprehensive inventory of the progresses achieved so far is both opportune and of paramount importance, in order to not only gather and summarize information, but to also allow fellow researchers to compare with ease and filter the best solutions for the cation substitution of HA-based materials and enable the development of multi-functional biomedical designs. The review surveys preparation and synthesis methods, pinpoints all the explored cation dopants, and discloses the full application range of substituted HA. Special attention is dedicated to the antimicrobial efficiency spectrum and cytotoxic trade-off concentration values for various cell lines, highlighting new prophylactic routes for the prevention of implant failure. Importantly, the current in vitro biological tests (widely employed to unveil the biological performance of HA-based materials), and their ability to mimic the in vivo biological interactions, are also critically assessed. Future perspectives are discussed, and a series of recommendations are underlined.

show abstract

Influence of pentavalent dopant addition to polarization and bioactivity of hydroxyapatite

Cited by 22 publications

References 43 publications

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Fabrication of Hydroxyapatite/Tantalum Composites by Pressureless Sintering in Different Atmosphere

Dielectric and AC conductivity studies of novel porous armalcolite nanocomposite‐based humidity sensor

Cationic Substitutions in Hydroxyapatite: Current Status of the Derived Biofunctional Effects and Their In Vitro Interrogation Methods

Contact Info

Product

Resources

About