Influence of PEG in PEG–PLGA microspheres on particle properties and protein release

Impact of PEG and PEG- b -PAGE modified PLGA on nanoparticle formation, protein loading and release

“…In many studies to date, the influence of changing numerous process parameters -such as the amount of polymer and drug used, the time for preparation, and the selected excipients (different emulsifier or release modifier) -on particles produced via the double emulsion method has been described (Buske et al, 2012;Corrigan and Li, 2009;Cruz et al, 2011;Feczkó et al, 2011;Mundargi et al, 2008). However, for comparison of the potential of a polymer to act as an encapsulation material it is of utmost importance to keep the majority of process parameters unchanged.…”

Submicron polycaprolactone particles as a carrier for imaging contrast agent for in vitro applications

“…Standard process allow for the encapsulation of lipophilic molecules into a multitude of particulate materials, however their application to hydrophilic compounds encapsulation is limited due to uncontrolled leakage of entrapped compounds during the preparation process [10][11][12]. However, double emulsion technique is an appropriate method for the encapsulation of hydrophilic molecules as well as hydrophobic molecules, additionally, it allows flexibility in particle size by adjusting process parameters, the process is independent of special laboratory equipment, the operation costs are low and preferable for low scale production [13,14]. Several polymeric materials such as polystyrene, dextran, chitosan poly (lactic acid) and poly (lactic-co-glycolic acid) has been used to develop multi-target and multifunctional particle loaded with fluorescent agent for optical imaging [15].…”

Adaptable poly(ethylene glycol) microspheres capable of mixed-mode degradation

“…Poly(ethylene glycol) (PEG) hydrogels have been commonly used in these applications due in part to their biological inertness and the relative ease of functionalization of the PEG polymer [3]. While hydrogels fabricated solely from PEG are typically stable in physiologic conditions, PEG copolymers can be designed to be labile over time, resulting in biodegradable hydrogels [3-5]. Biodegradable PEG hydrogels have been fabricated using a variety of chemistries, and have been engineered to degrade via simple hydrolytic or enzyme-catalyzed mechanisms [3-16].…”