Influence of PD‐1/PD‐L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma

Xu, Shuang-Bo; Wang, Meng‐Yao; Shi, Xinzhan; Wang, Qiong; Yu, Miao; Zhang, Wei; Xu, Xiaohui; Liu, Laikui

doi:10.1111/odi.14332

Cited by 4 publications

(2 citation statements)

References 27 publications

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“…Tumor epithelial cells can induce immune infiltration due to their antigenicity; however, the tumor also induces immune cell exhaustion to counteract the antitumor effect of TILs (Zapata et al, 2023). In the high-risk group, elevated expression of checkpoint genes, including those associated with exhaustion, was observed, indicating potential immunosuppression (Xu et al, 2022). These factors collectively contribute to the immunosuppressive condition and ultimately lead to a worse prognosis in the high-risk group.…”

Section: Discussionmentioning

confidence: 99%

Crosstalk among T cells, epithelial cells, and fibroblasts identifies a prognostic signature in oral squamous cell carcinoma

et al. 2023

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ObjectivesThis study aimed to analyze the crosstalk network among T cells, epithelial cells, and fibroblasts in the tumor microenvironment of oral squamous cell carcinoma (OSCC) and to determine their prognostic values.Materials and MethodsSingle‐cell subpopulation identification and communication analysis identified crosstalk markers. The least absolute shrinkage and selection operator Cox analysis identified key prognostic features by integrating the bulk transcriptome and clinical parameters. Functional analysis and immune infiltration were explored to determine possible mechanisms.ResultsInteractions between epithelial cells and fibroblasts primarily involve MIF, MK, PTN, IGF, EGF, and PERIOSTIN, whereas T cells interact with epithelial cells and fibroblasts through MIF, CXCL, PAR, IFN, and EGF signals. We constructed a novel prognostic feature comprising 13 crosstalk genes: HBEGF, FGF7, GRN, ITGB5, CXCR6, ERBB2, AREG, F2RL2, NAMPT, KLK12, HMGB2, TUBA1B, and KLRD1. Patients were stratified based on the RiskScore. Functional analysis revealed that the high‐risk group was enriched in immunosuppressive pathways (p < 0.001). Immune checkpoints including PD‐1, PD‐L1, and CTLA4 were more highly expressed in the high‐risk group (p < 0.05).ConclusionsThe crosstalk network among T cells, epithelial cells, and fibroblasts is complex and may have implications for prognosis and clinical treatments of OSCC patients.

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Section: Discussionmentioning

confidence: 99%

Crosstalk among T cells, epithelial cells, and fibroblasts identifies a prognostic signature in oral squamous cell carcinoma

et al. 2023

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“…A study conducted by Gannot and colleagues revealed the presence of higher numbers of immune cells in moderate and severe dysplasia or OSCC, compared to cases of hyperkeratosis without dysplasia or mild dysplasia (33). Xu et al have recently reported more CD3-and CD8positive T cells in OL with high-grade dysplasia as compared to cases of OL with low-grade dysplasia (34). Öhman et al reported an increased number of CD8-positive T cells in OL with dysplasia compared to OL without dysplasia (35), as well as an increased number of T cells in non-cancertransforming OL compared to cancer-transforming OL (36).…”

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confidence: 98%

EZH2 Expression Correlates With T-Cell Infiltration in Oral Leukoplakia and Predicts Cancer Transformation

et al. 2023

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Background/Aim: The EZH2 complex is involved in cellular proliferation and modulates the immune response in cancer. Less is known about the importance of EZH2 in precancerous lesions such as oral leukoplakia (OL). The aim of the study was to explore the association between EZH2 expression, immune activation, and cancer transformation in OL. found (r=0.57, p=0.01; r=0.59, p=0.01). The number of EZH2-expressing cells in the epithelium of OL-ca was significantly higher compared to OL-non (p=0.0002). Cancer-free survival rates differed significantly between patients with EZH2 high compared to EZH2 low expression (p=0.001). EZH2 high expression in OL epithelium was associated with a 13-fold higher risk for developing OSCC (HR=12.8). Conclusion: EZH2 expression in oral epithelium predicts OSCC transformation of OL and correlates with the level of T-cell infiltration. Patients and Methods: Analyses were retrospectively performed on nine OL cases that had undergone transformation to oral squamous cell carcinoma (OSCC; OL-ca) and nine that had not undergone transformation (OL-non). EZH2-expressing cells, CD3+ and CD8+ T cells, and CD1a+ Langerhans cells were visualized with immunohistofluorescence and counted. Results: A moderate positive correlation between CD3-and EZH2expressing and CD8-and EZH2-expressing cells in the epithelium was

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Development of a Pathomics-Based Model for the Prediction of Malignant Transformation in Oral Leukoplakia

Cai

et al. 2023

Laboratory Investigation

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Influence of PD‐1/PD‐L1 on immune microenvironment in oral leukoplakia and oral squamous cell carcinoma

Cited by 4 publications

References 27 publications

Crosstalk among T cells, epithelial cells, and fibroblasts identifies a prognostic signature in oral squamous cell carcinoma

Crosstalk among T cells, epithelial cells, and fibroblasts identifies a prognostic signature in oral squamous cell carcinoma

EZH2 Expression Correlates With T-Cell Infiltration in Oral Leukoplakia and Predicts Cancer Transformation

Development of a Pathomics-Based Model for the Prediction of Malignant Transformation in Oral Leukoplakia

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