Influence of pathogens and moderate leukocytes on seminal interleukin (IL)-6, IL-8, and sperm parameters

Aghazarian, Artin; Stancik, Igor; Pflüger, Heinz; Lackner, Jakob

doi:10.1007/s11255-013-0400-8

Cited by 25 publications

(25 citation statements)

References 23 publications

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“…In addition, the 75th percentile of IL-6 and IL-8 was used to define "high" levels of these cytokines in semen. On this basis, Eggert-Kruse et al 16 As previously reported, 18 we associated moderate leukocytes with increased levels of seminal IL-6 and IL-8, which raised questions concerning the diagnostic significance of leukocytospermia. Thus, we examined the patient population, as presented in our earlier study, 18 in greater detail using ROC curves.…”

supporting

confidence: 57%

Evaluation of Leukocyte Threshold Values in Semen to Detect Inflammation Involving Seminal Interleukin-6 and Interleukin-8

Aghazarian

Stancik

Huf

et al. 2015

Urology

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supporting

confidence: 57%

Evaluation of Leukocyte Threshold Values in Semen to Detect Inflammation Involving Seminal Interleukin-6 and Interleukin-8

Aghazarian

Stancik

Huf

et al. 2015

Urology

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“…Previous studies reported that leukocytospermia could exert a negative effect on semen quality [11,27] . We demonstrated that human semen samples with leukocytospermia showed lower levels of omentin-1, concomitant with higher level of seminal ROS, which has been reported to exert a negative effect on sperm quality [21,22] ,We hypothesize that the presence of leukocytes in semen, low level of omentin-1 and decreasing semen quality, could indicate a typical inflammation profile.…”

Section: Discussionmentioning

confidence: 99%

Omentin-1 in serum and seminal plasma correlate with semen quality

et al. 2017

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Introduction: Adipokines are differently regulated in the male reproductive tract and they were reported to affect sperm functionality. Serum omentin-1 was reported to have a range of effects on various cell types. Aim: To explore the presence of omentin-1in human semen, to investigate its relation with semen parameters in both fertile and infertile men and to compare its serum and seminal plasma levels in particular conditions such as; smoking, varicocele and leukocytospermia. Methods: Thirty nine infertile and 26 fertile men were enrolled in this case control study. They were subjected to history taking, clinical/physical examination, semen analysis, and measurement of omentin-1 in serum and seminal plasma, DNA fragmentation index (DFI) and seminal reactive oxygen species (ROS). Results: Omentin-1 was detected in all analyzed semen and serum samples (n=65). The concentration of omentin-1 was significantly higher in seminal plasma than in serum. Serum and seminal omentin-1 were positively correlated with sperm concentration and percentage of progressive motility and were negatively correlated with percentage of abnormal forms, DFI and ROS. The mean seminal plasma level of omentin-1 was significantly decreased in smokers and in patients with leukocytospermia. The mean serum level of omentin-1 was significantly decreased in patients with varicocele. Both serum and seminal omentin-1 levels were significantly lower in infertile patients than fertile men. Conclusions: Semen and serum Omentin-1 correlate with semen quality. In cases of leukocytospermia and smoking, seminal omentin-1 concentrations were decreased, suggesting that it may play a regulatory role in inflammation of the male reproductive system.

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“…Elevated cytokine presence in the semen has been also attributed to pathogens [135,162,166]. However, there are studies in which seminal pathogens have been found to have no influence on cytokine levels [167,168]. Among the various inflammatory cytokines, seminal IL-1b, IL-6, and IL-18 have been proposed for the role of specific biomarkers discriminating between patients with or without MAGI [165,169,170].…”

Section: Role Of the Immune/autoimmune Reactionsmentioning

confidence: 99%

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

Frączek

Kurpisz

2015

Folia Histochem Cytobiol.

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The invasion of the male reproductive tract by microorganisms, and its subsequent consequences for sperm fertilizing potential, has been intensely discussed. The role of the bacteria that are responsible for the colonization and contamination of the male urogenital tract, rather than its infection, in diminished sperm parameters raises the most controversy. There are numerous premises suggesting that bacterial semen infection is associated with male infertility. However, the molecular mechanism by which the fertility is affected is complex and multifactorial, and still presents a puzzle. Some authors have suggested that direct interactions between bacteria and human spermatozoa facilitate sperm immobilization, affect sperm morphology, and thus weaken the ability of sperm to fertilize. On the other hand, the massive infiltration of activated leukocytes into the inflammatory site may be associated with impairment of sperm fertilizing potential, due to oxidative, apoptotic, and immune processes. This review presents current research trends and aims to summarize the present knowledge of semen inflammation and causative bacterial agents in the male urogenital tract, with its consequence on seminological parameters, and male fertility status.

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Influence of pathogens and moderate leukocytes on seminal interleukin (IL)-6, IL-8, and sperm parameters

Abstract: Moderate leukocyte counts could be an indicator of male genital tract inflammation. Seminal pathogens have no influence on cytokine levels and sperm parameters.

Cited by 25 publications

References 23 publications

Evaluation of Leukocyte Threshold Values in Semen to Detect Inflammation Involving Seminal Interleukin-6 and Interleukin-8

Evaluation of Leukocyte Threshold Values in Semen to Detect Inflammation Involving Seminal Interleukin-6 and Interleukin-8

Omentin-1 in serum and seminal plasma correlate with semen quality

Mechanisms of the harmful effects of bacterial semen infection on ejaculated human spermatozoa: potential inflammatory markers in semen

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